Fish acute toxicity of nine nanomaterials: Need of pre-tests to ensure comparability and reuse of data

12 Pág.

Detalles Bibliográficos
Autores: Pulido-Reyes, Gerardo, Moreno-Martín, Gustavo, Gómez-Gómez, Beatriz, Navas, José María, Madrid-Albarrán, Y., Fernández-Cruz, M. L.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/346087
Acceso en línea:http://hdl.handle.net/10261/346087
https://api.elsevier.com/content/abstract/scopus_id/85181777143
Access Level:acceso abierto
Palabra clave:Acute
Fish
Nanomaterials
OECD
Test
id ES_1db0e71b5fb65ff2f56ecfba716fe4b7
oai_identifier_str oai:digital.csic.es:10261/346087
network_acronym_str ES
network_name_str España
repository_id_str
spelling Fish acute toxicity of nine nanomaterials: Need of pre-tests to ensure comparability and reuse of dataPulido-Reyes, GerardoMoreno-Martín, GustavoGómez-Gómez, BeatrizNavas, José MaríaMadrid-Albarrán, Y.Fernández-Cruz, M. L.AcuteFishNanomaterialsOECDTest12 Pág.Fish acute toxicity tests are commonly used in aquatic environmental risk assessments, being required in different international substances regulations. A general trend in the toxicity testing of nanomaterials (NMs) has been to use standardized aquatic toxicity tests. However, as these tests were primarily developed for soluble chemical, issues regarding particle dissolution, agglomeration or sedimentation during the time of exposure are not considered when reporting the toxicity of NMs. The aim of this study was to characterize the NM behaviour throughout the fish acute test and to provide criteria to assay the toxicity of nine NMs based on TiO2, ZnO, SiO2, BaSO4, bentonite, and carbon nanotubes, on rainbow trout following OECD Test Guideline (TG) nº203. Our results showed the importance of conducting a preliminary test (without fish) when working with NMs. They provide valuable information on, sample monitoring, agglomeration, sedimentation, dissolution, actual concentrations of NMs, needed to design the test. Among the NMs tested, only bentonite nanoparticles were stable during the 96-h pre-test and test in aquarium water. In contrast, the remaining NMs exhibited considerable loss and sedimentation within the first 24 h. The high sedimentation observed for almost all NMs highlights the need of consistently measuring the concentrations throughout the entire duration of the fish acute toxicity test to make reliable concentration-response relationships. Notable differences emerged in LC50 values when using actual concentrations as nominal concentrations overestimated concentrations by up to 85.6%. Among all NMs tested, only ZnO NMs were toxic to rainbow trout. A flow chart was specifically developed for OECD TG 203, aiding users in making informed decisions regarding the selection of test systems and necessary modifications to ensure accurate, reliable, and reusable toxicity data. Our findings might contribute to the harmonization of TG 203 improving result reproducibility and interpretability and supporting the development of read-across and QSAR models.This research has received funding from the European Union's Horizon 2020 research and innovation program for the NANOHARMONY project, under Grant Agreement No. 885931 .Peer reviewedAcademic PressEuropean CommissionPulido-Reyes, Gerardo [0000-0003-0853-9951]Moreno-Martín, Gustavo [0000-0001-9439-9590]Gómez-Gómez, Beatriz [0000-0003-4438-4571]Navas Antón, José María [0000-0002-7644-8499]Madrid-Albarrán, Y. [0000-0001-9017-0342]Fernández-Cruz, M. L. [0000-0001-5988-1939]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/346087https://api.elsevier.com/content/abstract/scopus_id/85181777143reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/H2020/885931Departamento de Medio Ambiente y Agronomía​https://doi.org/10.1016/j.envres.2023.118072Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3460872026-05-22T06:33:51Z
dc.title.none.fl_str_mv Fish acute toxicity of nine nanomaterials: Need of pre-tests to ensure comparability and reuse of data
title Fish acute toxicity of nine nanomaterials: Need of pre-tests to ensure comparability and reuse of data
spellingShingle Fish acute toxicity of nine nanomaterials: Need of pre-tests to ensure comparability and reuse of data
Pulido-Reyes, Gerardo
Acute
Fish
Nanomaterials
OECD
Test
title_short Fish acute toxicity of nine nanomaterials: Need of pre-tests to ensure comparability and reuse of data
title_full Fish acute toxicity of nine nanomaterials: Need of pre-tests to ensure comparability and reuse of data
title_fullStr Fish acute toxicity of nine nanomaterials: Need of pre-tests to ensure comparability and reuse of data
title_full_unstemmed Fish acute toxicity of nine nanomaterials: Need of pre-tests to ensure comparability and reuse of data
title_sort Fish acute toxicity of nine nanomaterials: Need of pre-tests to ensure comparability and reuse of data
dc.creator.none.fl_str_mv Pulido-Reyes, Gerardo
Moreno-Martín, Gustavo
Gómez-Gómez, Beatriz
Navas, José María
Madrid-Albarrán, Y.
Fernández-Cruz, M. L.
author Pulido-Reyes, Gerardo
author_facet Pulido-Reyes, Gerardo
Moreno-Martín, Gustavo
Gómez-Gómez, Beatriz
Navas, José María
Madrid-Albarrán, Y.
Fernández-Cruz, M. L.
author_role author
author2 Moreno-Martín, Gustavo
Gómez-Gómez, Beatriz
Navas, José María
Madrid-Albarrán, Y.
Fernández-Cruz, M. L.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv European Commission
Pulido-Reyes, Gerardo [0000-0003-0853-9951]
Moreno-Martín, Gustavo [0000-0001-9439-9590]
Gómez-Gómez, Beatriz [0000-0003-4438-4571]
Navas Antón, José María [0000-0002-7644-8499]
Madrid-Albarrán, Y. [0000-0001-9017-0342]
Fernández-Cruz, M. L. [0000-0001-5988-1939]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Acute
Fish
Nanomaterials
OECD
Test
topic Acute
Fish
Nanomaterials
OECD
Test
description 12 Pág.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/346087
https://api.elsevier.com/content/abstract/scopus_id/85181777143
url http://hdl.handle.net/10261/346087
https://api.elsevier.com/content/abstract/scopus_id/85181777143
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/H2020/885931
Departamento de Medio Ambiente y Agronomía​
https://doi.org/10.1016/j.envres.2023.118072
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Academic Press
publisher.none.fl_str_mv Academic Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869404294616186880
score 15,811543

Similares en LA Referencia