Interruption of onchocerciasis transmission in Bioko Island: Accelerating the movement from control to elimination in Equatorial Guinea

BACKGROUND: Onchocerciasis, also known as river blindness, is a parasitic disease. More than 99 percent of all cases occur in Africa. Bioko Island (Equatorial Guinea) is the only island endemic for onchocerciasis in the world. Since 2005, when vector Simulium yahense was eliminated, there have not b...

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Autores: Herrador, Zaida, Garcia, Belén, Ncogo, Policarpo, Perteguer-Prieto, Maria Jesus, Rubio Muñoz, Jose Miguel, Rivas, Eva, Cimas, Marta, Ordoñez, Guillermo, de Pablos, Silvia, Hernandez-Gonzalez, Ana, Nguema, Rufino, Moya-Alonso, Laura, Romay-Barja, Maria, Garate, Teresa, Barbre, Kira, Benito, Agustin
Formato: artículo
Fecha de publicación:2018
País:España
Recursos:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/6766
Acesso em linha:http://hdl.handle.net/20.500.12105/6766
Access Level:acceso abierto
Palavra-chave:Animals
Antibodies, Helminth
Child
Child, Preschool
Cross-Sectional Studies
Disease Eradication
Enzyme-Linked Immunosorbent Assay
Equatorial Guinea
Female
Humans
Immunoglobulin G
Insect Vectors
Islands
Male
Onchocerciasis
Simuliidae
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spelling Interruption of onchocerciasis transmission in Bioko Island: Accelerating the movement from control to elimination in Equatorial GuineaHerrador, ZaidaGarcia, BelénNcogo, PolicarpoPerteguer-Prieto, Maria JesusRubio Muñoz, Jose MiguelRivas, EvaCimas, MartaOrdoñez, Guillermode Pablos, SilviaHernandez-Gonzalez, AnaNguema, RufinoMoya-Alonso, LauraRomay-Barja, MariaGarate, TeresaBarbre, KiraBenito, AgustinAnimalsAntibodies, HelminthChildChild, PreschoolCross-Sectional StudiesDisease EradicationEnzyme-Linked Immunosorbent AssayEquatorial GuineaFemaleHumansImmunoglobulin GInsect VectorsIslandsMaleOnchocerciasisSimuliidaeBACKGROUND: Onchocerciasis, also known as river blindness, is a parasitic disease. More than 99 percent of all cases occur in Africa. Bioko Island (Equatorial Guinea) is the only island endemic for onchocerciasis in the world. Since 2005, when vector Simulium yahense was eliminated, there have not been any reported cases of infection. This study aimed to demonstrate that updated WHO criteria for stopping mass drug administration (MDA) have been met. METHODOLOGY/PRINCIPAL FINDINGS: A cross-sectional study was conducted from September 2016 to January 2017. Participants were 5- to 9-year-old school children. Onchocerciasis/lymphatic Filariasis (LF, only in endemic districts) rapid diagnostic tests (RDTs) were performed. Blood spots were collected from RDT positive children and 10 percent of the RDT negatives to determine Ov16 and Wb123 IgG4 antibodies through enzyme-linked immunosorbent assay (ELISA). Skin snips were collected from RDT positives. Filarial detection was performed by PCR in positives and indeterminate sera. Black fly collection was carried out in traditional breeding sites. A total of 7,052 children, ranging from 5 to 9 years of age, were included in the study. Four children (0.06%) were Ov16 IgG4 RDT positives, but negative by ELISA Ov16, while 6 RDT negative children tested positive by ELISA. A total of 1,230 children from the Riaba and Baney districts were tested for LF. One child was Wb123 RDT positive (0.08%), but ELISA negative, while 3 RDT negative children were positive by Wb123 ELISA. All positive samples were negative by PCR for onchocerciasis and LF (in blood spot and skin snip). All fly collections and larval prospections in the traditional catching and prospection sites were negative. CONCLUSIONS/SIGNIFICANCE: WHO criteria have been met, therefore MDA in Bioko Island can be stopped. Three years of post-treatment surveillance should be implemented to identify any new occurrences of exposure or infection.Public Library of Science (PLOS)Instituto de Salud Carlos IIIBill & Melinda Gates FoundationDepartment for International Development (Reino Unido)United States Agency for International Development20182018-12-0520182018-01-0120182018-01-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/6766reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/67662026-06-12T12:43:37Z
dc.title.none.fl_str_mv Interruption of onchocerciasis transmission in Bioko Island: Accelerating the movement from control to elimination in Equatorial Guinea
title Interruption of onchocerciasis transmission in Bioko Island: Accelerating the movement from control to elimination in Equatorial Guinea
spellingShingle Interruption of onchocerciasis transmission in Bioko Island: Accelerating the movement from control to elimination in Equatorial Guinea
Herrador, Zaida
Animals
Antibodies, Helminth
Child
Child, Preschool
Cross-Sectional Studies
Disease Eradication
Enzyme-Linked Immunosorbent Assay
Equatorial Guinea
Female
Humans
Immunoglobulin G
Insect Vectors
Islands
Male
Onchocerciasis
Simuliidae
title_short Interruption of onchocerciasis transmission in Bioko Island: Accelerating the movement from control to elimination in Equatorial Guinea
title_full Interruption of onchocerciasis transmission in Bioko Island: Accelerating the movement from control to elimination in Equatorial Guinea
title_fullStr Interruption of onchocerciasis transmission in Bioko Island: Accelerating the movement from control to elimination in Equatorial Guinea
title_full_unstemmed Interruption of onchocerciasis transmission in Bioko Island: Accelerating the movement from control to elimination in Equatorial Guinea
title_sort Interruption of onchocerciasis transmission in Bioko Island: Accelerating the movement from control to elimination in Equatorial Guinea
dc.creator.none.fl_str_mv Herrador, Zaida
Garcia, Belén
Ncogo, Policarpo
Perteguer-Prieto, Maria Jesus
Rubio Muñoz, Jose Miguel
Rivas, Eva
Cimas, Marta
Ordoñez, Guillermo
de Pablos, Silvia
Hernandez-Gonzalez, Ana
Nguema, Rufino
Moya-Alonso, Laura
Romay-Barja, Maria
Garate, Teresa
Barbre, Kira
Benito, Agustin
author Herrador, Zaida
author_facet Herrador, Zaida
Garcia, Belén
Ncogo, Policarpo
Perteguer-Prieto, Maria Jesus
Rubio Muñoz, Jose Miguel
Rivas, Eva
Cimas, Marta
Ordoñez, Guillermo
de Pablos, Silvia
Hernandez-Gonzalez, Ana
Nguema, Rufino
Moya-Alonso, Laura
Romay-Barja, Maria
Garate, Teresa
Barbre, Kira
Benito, Agustin
author_role author
author2 Garcia, Belén
Ncogo, Policarpo
Perteguer-Prieto, Maria Jesus
Rubio Muñoz, Jose Miguel
Rivas, Eva
Cimas, Marta
Ordoñez, Guillermo
de Pablos, Silvia
Hernandez-Gonzalez, Ana
Nguema, Rufino
Moya-Alonso, Laura
Romay-Barja, Maria
Garate, Teresa
Barbre, Kira
Benito, Agustin
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
Bill & Melinda Gates Foundation
Department for International Development (Reino Unido)
United States Agency for International Development
dc.subject.none.fl_str_mv Animals
Antibodies, Helminth
Child
Child, Preschool
Cross-Sectional Studies
Disease Eradication
Enzyme-Linked Immunosorbent Assay
Equatorial Guinea
Female
Humans
Immunoglobulin G
Insect Vectors
Islands
Male
Onchocerciasis
Simuliidae
topic Animals
Antibodies, Helminth
Child
Child, Preschool
Cross-Sectional Studies
Disease Eradication
Enzyme-Linked Immunosorbent Assay
Equatorial Guinea
Female
Humans
Immunoglobulin G
Insect Vectors
Islands
Male
Onchocerciasis
Simuliidae
description BACKGROUND: Onchocerciasis, also known as river blindness, is a parasitic disease. More than 99 percent of all cases occur in Africa. Bioko Island (Equatorial Guinea) is the only island endemic for onchocerciasis in the world. Since 2005, when vector Simulium yahense was eliminated, there have not been any reported cases of infection. This study aimed to demonstrate that updated WHO criteria for stopping mass drug administration (MDA) have been met. METHODOLOGY/PRINCIPAL FINDINGS: A cross-sectional study was conducted from September 2016 to January 2017. Participants were 5- to 9-year-old school children. Onchocerciasis/lymphatic Filariasis (LF, only in endemic districts) rapid diagnostic tests (RDTs) were performed. Blood spots were collected from RDT positive children and 10 percent of the RDT negatives to determine Ov16 and Wb123 IgG4 antibodies through enzyme-linked immunosorbent assay (ELISA). Skin snips were collected from RDT positives. Filarial detection was performed by PCR in positives and indeterminate sera. Black fly collection was carried out in traditional breeding sites. A total of 7,052 children, ranging from 5 to 9 years of age, were included in the study. Four children (0.06%) were Ov16 IgG4 RDT positives, but negative by ELISA Ov16, while 6 RDT negative children tested positive by ELISA. A total of 1,230 children from the Riaba and Baney districts were tested for LF. One child was Wb123 RDT positive (0.08%), but ELISA negative, while 3 RDT negative children were positive by Wb123 ELISA. All positive samples were negative by PCR for onchocerciasis and LF (in blood spot and skin snip). All fly collections and larval prospections in the traditional catching and prospection sites were negative. CONCLUSIONS/SIGNIFICANCE: WHO criteria have been met, therefore MDA in Bioko Island can be stopped. Three years of post-treatment surveillance should be implemented to identify any new occurrences of exposure or infection.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-12-05
2018
2018-01-01
2018
2018-01-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/6766
url http://hdl.handle.net/20.500.12105/6766
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLOS)
publisher.none.fl_str_mv Public Library of Science (PLOS)
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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