Autoimmune diseases are linked to type IIb autoimmune chronic spontaneous urticaria
Purpose: Patients with chronic spontaneous urticaria (CSU) have an increased risk for comorbid autoimmune diseases. In this retrospective multicenter study of CSU patients, we evaluated clinical and laboratory features of CSU associated with a higher risk of comorbid autoimmune diseases. Methods: We...
| Autores: | , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/49244 |
| Acceso en línea: | http://hdl.handle.net/10230/49244 http://dx.doi.org/10.4168/aair.2021.13.4.545 |
| Access Level: | acceso abierto |
| Palabra clave: | Chronic urticaria Autoantibodies Autoimmune diseases Autoimmune thyroiditis Autoimmunity Immunoassay Omalizumab Vitiligo |
| id |
ES_1d8cbbf815d613ac2134bc1a55de2d64 |
|---|---|
| oai_identifier_str |
oai:recercat.cat:10230/49244 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
Autoimmune diseases are linked to type IIb autoimmune chronic spontaneous urticariaKolkhir, PavelAltrichter, SabineAsero, RiccardoDaschner, AlvaroFerrer, MartaGiménez Arnau, Anna MariaHawro, TomaszJakob, ThiloKinaciyan, TamarKromminga, ArnoKonstantinou, George N.Makris, MichaelMetz, MartinSkov, Per StahlStaubach, PetraSussman, GordonZhang, KeMaurer, MarcusChronic urticariaAutoantibodiesAutoimmune diseasesAutoimmune thyroiditisAutoimmunityImmunoassayOmalizumabVitiligoPurpose: Patients with chronic spontaneous urticaria (CSU) have an increased risk for comorbid autoimmune diseases. In this retrospective multicenter study of CSU patients, we evaluated clinical and laboratory features of CSU associated with a higher risk of comorbid autoimmune diseases. Methods: We analyzed records of CSU patients (n = 1,199) for a history or presence of autoimmune diseases. Patients were diagnosed with type IIb autoimmune CSU (aiCSU) if all 3 tests were positive: autologous serum skin test (ASST), basophil histamine release assay (BHRA) and/or basophil activation test (BAT), and IgG autoantibodies against FcεRIα/IgE detected by immunoassay. Results: Twenty-eight percent of CSU patients had at least 1 autoimmune disease. The most prevalent autoimmune diseases were Hashimoto's thyroiditis (HT) (≥ 21%) and vitiligo (2%). Two percent of CSU patients had ≥ 2 autoimmune diseases, most frequently HT plus vitiligo. Comorbid autoimmune diseases, in patients with CSU, were associated with female sex, a family history of autoimmune diseases, and higher rates of hypothyroidism and hyperthyroidism (P < 0.001). Presence of autoimmune diseases was linked to aiCSU (P = 0.02). The risks of having autoimmune diseases were 1.7, 2.9 and 3.3 times higher for CSU patients with a positive ASST, BHRA and BAT, respectively. In CSU patients, markers for autoimmune diseases, antinuclear antibodies and/or IgG anti-thyroid antibodies were associated with non-response to omalizumab treatment (P = 0.013). Conclusions: In CSU, autoimmune diseases are common and linked to type IIb autoimmune CSU. Our results suggest that physicians assess and monitor all adult patients with CSU for signs and symptoms of common autoimmune diseases, especially HT and vitiligo.Korean Academy of Asthma, Allergy and Clinical ImmunologyKorean Academy of Pediatric Allergy and Respiratory Disease202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/49244http://dx.doi.org/10.4168/aair.2021.13.4.545reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésAllergy Asthma Immunol Res. 2021;13(4):545-59© 2021 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/492442026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Autoimmune diseases are linked to type IIb autoimmune chronic spontaneous urticaria |
| title |
Autoimmune diseases are linked to type IIb autoimmune chronic spontaneous urticaria |
| spellingShingle |
Autoimmune diseases are linked to type IIb autoimmune chronic spontaneous urticaria Kolkhir, Pavel Chronic urticaria Autoantibodies Autoimmune diseases Autoimmune thyroiditis Autoimmunity Immunoassay Omalizumab Vitiligo |
| title_short |
Autoimmune diseases are linked to type IIb autoimmune chronic spontaneous urticaria |
| title_full |
Autoimmune diseases are linked to type IIb autoimmune chronic spontaneous urticaria |
| title_fullStr |
Autoimmune diseases are linked to type IIb autoimmune chronic spontaneous urticaria |
| title_full_unstemmed |
Autoimmune diseases are linked to type IIb autoimmune chronic spontaneous urticaria |
| title_sort |
Autoimmune diseases are linked to type IIb autoimmune chronic spontaneous urticaria |
| dc.creator.none.fl_str_mv |
Kolkhir, Pavel Altrichter, Sabine Asero, Riccardo Daschner, Alvaro Ferrer, Marta Giménez Arnau, Anna Maria Hawro, Tomasz Jakob, Thilo Kinaciyan, Tamar Kromminga, Arno Konstantinou, George N. Makris, Michael Metz, Martin Skov, Per Stahl Staubach, Petra Sussman, Gordon Zhang, Ke Maurer, Marcus |
| author |
Kolkhir, Pavel |
| author_facet |
Kolkhir, Pavel Altrichter, Sabine Asero, Riccardo Daschner, Alvaro Ferrer, Marta Giménez Arnau, Anna Maria Hawro, Tomasz Jakob, Thilo Kinaciyan, Tamar Kromminga, Arno Konstantinou, George N. Makris, Michael Metz, Martin Skov, Per Stahl Staubach, Petra Sussman, Gordon Zhang, Ke Maurer, Marcus |
| author_role |
author |
| author2 |
Altrichter, Sabine Asero, Riccardo Daschner, Alvaro Ferrer, Marta Giménez Arnau, Anna Maria Hawro, Tomasz Jakob, Thilo Kinaciyan, Tamar Kromminga, Arno Konstantinou, George N. Makris, Michael Metz, Martin Skov, Per Stahl Staubach, Petra Sussman, Gordon Zhang, Ke Maurer, Marcus |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Chronic urticaria Autoantibodies Autoimmune diseases Autoimmune thyroiditis Autoimmunity Immunoassay Omalizumab Vitiligo |
| topic |
Chronic urticaria Autoantibodies Autoimmune diseases Autoimmune thyroiditis Autoimmunity Immunoassay Omalizumab Vitiligo |
| description |
Purpose: Patients with chronic spontaneous urticaria (CSU) have an increased risk for comorbid autoimmune diseases. In this retrospective multicenter study of CSU patients, we evaluated clinical and laboratory features of CSU associated with a higher risk of comorbid autoimmune diseases. Methods: We analyzed records of CSU patients (n = 1,199) for a history or presence of autoimmune diseases. Patients were diagnosed with type IIb autoimmune CSU (aiCSU) if all 3 tests were positive: autologous serum skin test (ASST), basophil histamine release assay (BHRA) and/or basophil activation test (BAT), and IgG autoantibodies against FcεRIα/IgE detected by immunoassay. Results: Twenty-eight percent of CSU patients had at least 1 autoimmune disease. The most prevalent autoimmune diseases were Hashimoto's thyroiditis (HT) (≥ 21%) and vitiligo (2%). Two percent of CSU patients had ≥ 2 autoimmune diseases, most frequently HT plus vitiligo. Comorbid autoimmune diseases, in patients with CSU, were associated with female sex, a family history of autoimmune diseases, and higher rates of hypothyroidism and hyperthyroidism (P < 0.001). Presence of autoimmune diseases was linked to aiCSU (P = 0.02). The risks of having autoimmune diseases were 1.7, 2.9 and 3.3 times higher for CSU patients with a positive ASST, BHRA and BAT, respectively. In CSU patients, markers for autoimmune diseases, antinuclear antibodies and/or IgG anti-thyroid antibodies were associated with non-response to omalizumab treatment (P = 0.013). Conclusions: In CSU, autoimmune diseases are common and linked to type IIb autoimmune CSU. Our results suggest that physicians assess and monitor all adult patients with CSU for signs and symptoms of common autoimmune diseases, especially HT and vitiligo. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021 2021 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10230/49244 http://dx.doi.org/10.4168/aair.2021.13.4.545 |
| url |
http://hdl.handle.net/10230/49244 http://dx.doi.org/10.4168/aair.2021.13.4.545 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Allergy Asthma Immunol Res. 2021;13(4):545-59 |
| dc.rights.none.fl_str_mv |
https://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Korean Academy of Asthma, Allergy and Clinical Immunology Korean Academy of Pediatric Allergy and Respiratory Disease |
| publisher.none.fl_str_mv |
Korean Academy of Asthma, Allergy and Clinical Immunology Korean Academy of Pediatric Allergy and Respiratory Disease |
| dc.source.none.fl_str_mv |
reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str |
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| reponame_str |
Recercat. Dipósit de la Recerca de Catalunya |
| collection |
Recercat. Dipósit de la Recerca de Catalunya |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869404286014717952 |
| score |
15.811543 |