Structural brain changes and cognition in relation to markers of vascular dysfunction

The aim was to investigate the relationship between blood markers of vascular dysfunction with brain microstructural changes and cognition. Eighty-six participants from the Barcelona-Asymptomatic Intracranial Atherosclerosis (AsIA) neuropsychology study were included. Subjects were 50–65 years old,...

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Autores: Miralbell Blanch, Júlia, Soriano Raya, Juan José, Spulber, Gabriela, López Cancio, Elena, Arenillas, Juan Francisco, Bargalló Alabart, Núria, Galán, Amparo, Barrios Cerrejón, M. Teresa, Cáceres, Cynthia, Alzamora, María Teresa, Pera, Guillem, Kivipelto, Miia, Wahlund, Lars-Olof, Dávalos, Antoni, Mataró Serrat, Maria
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2012
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/226410
Acceso en línea:https://hdl.handle.net/2445/226410
Access Level:acceso abierto
Palabra clave:Malalties cerebrovasculars
Cervell
Cerebrovascular disease
Brain
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spelling Structural brain changes and cognition in relation to markers of vascular dysfunctionMiralbell Blanch, JúliaSoriano Raya, Juan JoséSpulber, GabrielaLópez Cancio, ElenaArenillas, Juan FranciscoBargalló Alabart, NúriaGalán, AmparoBarrios Cerrejón, M. TeresaCáceres, CynthiaAlzamora, María TeresaPera, GuillemKivipelto, MiiaWahlund, Lars-OlofDávalos, AntoniMataró Serrat, MariaMalalties cerebrovascularsCervellCerebrovascular diseaseBrainThe aim was to investigate the relationship between blood markers of vascular dysfunction with brain microstructural changes and cognition. Eighty-six participants from the Barcelona-Asymptomatic Intracranial Atherosclerosis (AsIA) neuropsychology study were included. Subjects were 50–65 years old, free from dementia and without history of vascular disease. We assessed correlations of blood levels of inflammatory biomarkers (C-reactive protein [CRP] and resistin) and fibrinolysis inhibitors (plasminogen activator inhibitor-1 [PAI-1] and A-lipoprotein (Lp (a)) with fractional anisotropy (FA) measurements of diffusion tensor images (DTI), regional gray matter (GM) volumes and performance in several cognitive domains. Increasing levels of C-reactive protein and PAI-1 levels were associated with white matter (WM) integrity loss in corticosubcortical pathways and association fibers of frontal and temporal lobes, independently of age, sex and vascular risk factors. PAI-1 was also related to lower speed and visuomotor/coordination. None of the biomarkers were related to gray matter volume changes. Our findings suggest that inflammation and dysregulation of the fibrynolitic system may be involved in the pathological mechanisms underlying the WM damage seen in cerebrovascular disease and subsequent cognitive impairment.Elsevier B.V.2012info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/226410Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1016/j.neurobiolaging.2011.09.020Neurobiology of Aging, 2012, vol. 33, num.5, p. 1003.e9-1003.e17https://doi.org/10.1016/j.neurobiolaging.2011.09.020(c) Elsevier B.V., 2012info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2264102026-05-27T06:46:51Z
dc.title.none.fl_str_mv Structural brain changes and cognition in relation to markers of vascular dysfunction
title Structural brain changes and cognition in relation to markers of vascular dysfunction
spellingShingle Structural brain changes and cognition in relation to markers of vascular dysfunction
Miralbell Blanch, Júlia
Malalties cerebrovasculars
Cervell
Cerebrovascular disease
Brain
title_short Structural brain changes and cognition in relation to markers of vascular dysfunction
title_full Structural brain changes and cognition in relation to markers of vascular dysfunction
title_fullStr Structural brain changes and cognition in relation to markers of vascular dysfunction
title_full_unstemmed Structural brain changes and cognition in relation to markers of vascular dysfunction
title_sort Structural brain changes and cognition in relation to markers of vascular dysfunction
dc.creator.none.fl_str_mv Miralbell Blanch, Júlia
Soriano Raya, Juan José
Spulber, Gabriela
López Cancio, Elena
Arenillas, Juan Francisco
Bargalló Alabart, Núria
Galán, Amparo
Barrios Cerrejón, M. Teresa
Cáceres, Cynthia
Alzamora, María Teresa
Pera, Guillem
Kivipelto, Miia
Wahlund, Lars-Olof
Dávalos, Antoni
Mataró Serrat, Maria
author Miralbell Blanch, Júlia
author_facet Miralbell Blanch, Júlia
Soriano Raya, Juan José
Spulber, Gabriela
López Cancio, Elena
Arenillas, Juan Francisco
Bargalló Alabart, Núria
Galán, Amparo
Barrios Cerrejón, M. Teresa
Cáceres, Cynthia
Alzamora, María Teresa
Pera, Guillem
Kivipelto, Miia
Wahlund, Lars-Olof
Dávalos, Antoni
Mataró Serrat, Maria
author_role author
author2 Soriano Raya, Juan José
Spulber, Gabriela
López Cancio, Elena
Arenillas, Juan Francisco
Bargalló Alabart, Núria
Galán, Amparo
Barrios Cerrejón, M. Teresa
Cáceres, Cynthia
Alzamora, María Teresa
Pera, Guillem
Kivipelto, Miia
Wahlund, Lars-Olof
Dávalos, Antoni
Mataró Serrat, Maria
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malalties cerebrovasculars
Cervell
Cerebrovascular disease
Brain
topic Malalties cerebrovasculars
Cervell
Cerebrovascular disease
Brain
description The aim was to investigate the relationship between blood markers of vascular dysfunction with brain microstructural changes and cognition. Eighty-six participants from the Barcelona-Asymptomatic Intracranial Atherosclerosis (AsIA) neuropsychology study were included. Subjects were 50–65 years old, free from dementia and without history of vascular disease. We assessed correlations of blood levels of inflammatory biomarkers (C-reactive protein [CRP] and resistin) and fibrinolysis inhibitors (plasminogen activator inhibitor-1 [PAI-1] and A-lipoprotein (Lp (a)) with fractional anisotropy (FA) measurements of diffusion tensor images (DTI), regional gray matter (GM) volumes and performance in several cognitive domains. Increasing levels of C-reactive protein and PAI-1 levels were associated with white matter (WM) integrity loss in corticosubcortical pathways and association fibers of frontal and temporal lobes, independently of age, sex and vascular risk factors. PAI-1 was also related to lower speed and visuomotor/coordination. None of the biomarkers were related to gray matter volume changes. Our findings suggest that inflammation and dysregulation of the fibrynolitic system may be involved in the pathological mechanisms underlying the WM damage seen in cerebrovascular disease and subsequent cognitive impairment.
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/226410
url https://hdl.handle.net/2445/226410
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.neurobiolaging.2011.09.020
Neurobiology of Aging, 2012, vol. 33, num.5, p. 1003.e9-1003.e17
https://doi.org/10.1016/j.neurobiolaging.2011.09.020
dc.rights.none.fl_str_mv (c) Elsevier B.V., 2012
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Elsevier B.V., 2012
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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