Are Mitochondrial Fusion and Fission Impaired in Leukocytes of Type 2 Diabetic Patients?

Díaz Morales, Noelia; Rovira-Llopis, Susana; Bañuls, Celia; Escribano-Lopez, Irene; de Marañon, Arantxa Martinez; Lopez-Domenech, Sandra; Orden, Samuel; Roldan-Torres, Ildefonso; Alvarez, Angeles; Veses, Silvia; Jover, Ana; Rocha, Milagros; Hernandez-Mijares, Antonio; Victor, Victor M.

Are Mitochondrial Fusion and Fission Impaired in Leukocytes of Type 2 Diabetic Patients?

[EN]Mitochondrial fusion/fission alterations have been evaluated in different tissues of type 2 diabetic (T2D) patients. However, it is not known whether mitochondrial dynamics is disturbed in the leukocytes of T2D patients and whether glycemic control affects its regulation. Anthropometric and meta...

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Autores:	Díaz Morales, Noelia, Rovira-Llopis, Susana, Bañuls, Celia, Escribano-Lopez, Irene, de Marañon, Arantxa Martinez, Lopez-Domenech, Sandra, Orden, Samuel, Roldan-Torres, Ildefonso, Alvarez, Angeles, Veses, Silvia, Jover, Ana, Rocha, Milagros, Hernandez-Mijares, Antonio, Victor, Victor M.
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2016
País:	España
Institución:	Universidad de Salamanca (USAL)
Repositorio:	GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:	oai:gredos.usal.es:10366/169703
Acceso en línea:	http://hdl.handle.net/10366/169703
Access Level:	acceso embargado
Palabra clave:	Diabetes mellitus tipo 2 Mitocondria Dinámica mitocondrial (Fusión y Fisión) Leucocitos Estrés oxidativo Morfología mitocondrial Control glucémico Adhesión leucocitaria Type 2 Diabetes Mitochondria Mitochondrial dynamics (Fusion and Fission) Leukocytes Oxidative stress Mitochondrial morphology Glycemic control leukocyte-endothelial interactions Diabetes Mellitus, Type 2 Oxidative Stress Mitochondrial Dynamics 3209 Farmacología 2410.10 Fisiología Humana 2302 Bioquímica 2411.04 Fisiología Endocrina 2407 Biología Celular diabetes mellitus tipo II mitocondrias estrés oxidativo dinámica mitocondrial leucocitos

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spelling	Are Mitochondrial Fusion and Fission Impaired in Leukocytes of Type 2 Diabetic Patients?Díaz Morales, NoeliaRovira-Llopis, SusanaBañuls, CeliaEscribano-Lopez, Irenede Marañon, Arantxa MartinezLopez-Domenech, SandraOrden, SamuelRoldan-Torres, IldefonsoAlvarez, AngelesVeses, SilviaJover, AnaRocha, MilagrosHernandez-Mijares, AntonioVictor, Victor M.Diabetes mellitus tipo 2MitocondriaDinámica mitocondrial (Fusión y Fisión)LeucocitosEstrés oxidativoMorfología mitocondrialControl glucémicoAdhesión leucocitariaType 2 DiabetesMitochondriaMitochondrial dynamics (Fusion and Fission)LeukocytesOxidative stressMitochondrial morphologyGlycemic controlleukocyte-endothelial interactionsDiabetes Mellitus, Type 2Oxidative StressMitochondriaMitochondrial DynamicsLeukocytes3209 Farmacología2410.10 Fisiología Humana2302 Bioquímica2411.04 Fisiología Endocrina2407 Biología Celulardiabetes mellitus tipo IImitocondriasestrés oxidativodinámica mitocondrialleucocitos[EN]Mitochondrial fusion/fission alterations have been evaluated in different tissues of type 2 diabetic (T2D) patients. However, it is not known whether mitochondrial dynamics is disturbed in the leukocytes of T2D patients and whether glycemic control affects its regulation. Anthropometric and metabolic parameters in 91 T2D patients (48 with glycated hemoglobin [HbA1c] <6.5% and 43 with HbA1c >6.5%) were characteristic of the disease when compared with 78 control subjects. We observed increased reactive oxygen species production in leukocytes from diabetic patients, together with a reduced mitochondrial oxygen consumption rate, especially in poorly controlled patients. Mitochondrial fusion was reduced and fission was increased in diabetic patients, and both features were accentuated in patients with poor glycemic control. Furthermore, leukocyte rolling flux rose in parallel to HbA1c levels. The induction of leukocyte-endothelial interactions in diabetic patients was related to reduced mitochondrial fusion and higher mitochondrial fission. Our findings suggest that mitochondrial dynamics could be influenced by glycemic control in leukocytes of diabetic patients, in which there is decreased mitochondrial fusion and elevated fission related to enhanced leukocyte-endothelial interactions. These findings lead to the hypothesis that poor glycemic control during T2D may alter mitochondrial dynamics and could eventually promote leukocyte-endothelial interactions and the onset of cardiovascular diseasesFondo Europeo de Desarrollo Regional (FEDER), Instituto de Salud Carlos III (ISCIII), Ministerio de Ciencia e Innovación, CIBERehd, Generalitat Valencianainfo202620262016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10366/169703reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésPI12/1984PI13/1025PI13/0073PI15/1424CB06/04/0071PROMETEOII2014/035Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/embargoedAccessoai:gredos.usal.es:10366/1697032026-06-07T06:28:51Z
dc.title.none.fl_str_mv	Are Mitochondrial Fusion and Fission Impaired in Leukocytes of Type 2 Diabetic Patients?
title	Are Mitochondrial Fusion and Fission Impaired in Leukocytes of Type 2 Diabetic Patients?
spellingShingle	Are Mitochondrial Fusion and Fission Impaired in Leukocytes of Type 2 Diabetic Patients? Díaz Morales, Noelia Diabetes mellitus tipo 2 Mitocondria Dinámica mitocondrial (Fusión y Fisión) Leucocitos Estrés oxidativo Morfología mitocondrial Control glucémico Adhesión leucocitaria Type 2 Diabetes Mitochondria Mitochondrial dynamics (Fusion and Fission) Leukocytes Oxidative stress Mitochondrial morphology Glycemic control leukocyte-endothelial interactions Diabetes Mellitus, Type 2 Oxidative Stress Mitochondria Mitochondrial Dynamics Leukocytes 3209 Farmacología 2410.10 Fisiología Humana 2302 Bioquímica 2411.04 Fisiología Endocrina 2407 Biología Celular diabetes mellitus tipo II mitocondrias estrés oxidativo dinámica mitocondrial leucocitos
title_short	Are Mitochondrial Fusion and Fission Impaired in Leukocytes of Type 2 Diabetic Patients?
title_full	Are Mitochondrial Fusion and Fission Impaired in Leukocytes of Type 2 Diabetic Patients?
title_fullStr	Are Mitochondrial Fusion and Fission Impaired in Leukocytes of Type 2 Diabetic Patients?
title_full_unstemmed	Are Mitochondrial Fusion and Fission Impaired in Leukocytes of Type 2 Diabetic Patients?
title_sort	Are Mitochondrial Fusion and Fission Impaired in Leukocytes of Type 2 Diabetic Patients?
dc.creator.none.fl_str_mv	Díaz Morales, Noelia Rovira-Llopis, Susana Bañuls, Celia Escribano-Lopez, Irene de Marañon, Arantxa Martinez Lopez-Domenech, Sandra Orden, Samuel Roldan-Torres, Ildefonso Alvarez, Angeles Veses, Silvia Jover, Ana Rocha, Milagros Hernandez-Mijares, Antonio Victor, Victor M.
author	Díaz Morales, Noelia
author_facet	Díaz Morales, Noelia Rovira-Llopis, Susana Bañuls, Celia Escribano-Lopez, Irene de Marañon, Arantxa Martinez Lopez-Domenech, Sandra Orden, Samuel Roldan-Torres, Ildefonso Alvarez, Angeles Veses, Silvia Jover, Ana Rocha, Milagros Hernandez-Mijares, Antonio Victor, Victor M.
author_role	author
author2	Rovira-Llopis, Susana Bañuls, Celia Escribano-Lopez, Irene de Marañon, Arantxa Martinez Lopez-Domenech, Sandra Orden, Samuel Roldan-Torres, Ildefonso Alvarez, Angeles Veses, Silvia Jover, Ana Rocha, Milagros Hernandez-Mijares, Antonio Victor, Victor M.
author2_role	author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Diabetes mellitus tipo 2 Mitocondria Dinámica mitocondrial (Fusión y Fisión) Leucocitos Estrés oxidativo Morfología mitocondrial Control glucémico Adhesión leucocitaria Type 2 Diabetes Mitochondria Mitochondrial dynamics (Fusion and Fission) Leukocytes Oxidative stress Mitochondrial morphology Glycemic control leukocyte-endothelial interactions Diabetes Mellitus, Type 2 Oxidative Stress Mitochondria Mitochondrial Dynamics Leukocytes 3209 Farmacología 2410.10 Fisiología Humana 2302 Bioquímica 2411.04 Fisiología Endocrina 2407 Biología Celular diabetes mellitus tipo II mitocondrias estrés oxidativo dinámica mitocondrial leucocitos
topic	Diabetes mellitus tipo 2 Mitocondria Dinámica mitocondrial (Fusión y Fisión) Leucocitos Estrés oxidativo Morfología mitocondrial Control glucémico Adhesión leucocitaria Type 2 Diabetes Mitochondria Mitochondrial dynamics (Fusion and Fission) Leukocytes Oxidative stress Mitochondrial morphology Glycemic control leukocyte-endothelial interactions Diabetes Mellitus, Type 2 Oxidative Stress Mitochondria Mitochondrial Dynamics Leukocytes 3209 Farmacología 2410.10 Fisiología Humana 2302 Bioquímica 2411.04 Fisiología Endocrina 2407 Biología Celular diabetes mellitus tipo II mitocondrias estrés oxidativo dinámica mitocondrial leucocitos
description	[EN]Mitochondrial fusion/fission alterations have been evaluated in different tissues of type 2 diabetic (T2D) patients. However, it is not known whether mitochondrial dynamics is disturbed in the leukocytes of T2D patients and whether glycemic control affects its regulation. Anthropometric and metabolic parameters in 91 T2D patients (48 with glycated hemoglobin [HbA1c] <6.5% and 43 with HbA1c >6.5%) were characteristic of the disease when compared with 78 control subjects. We observed increased reactive oxygen species production in leukocytes from diabetic patients, together with a reduced mitochondrial oxygen consumption rate, especially in poorly controlled patients. Mitochondrial fusion was reduced and fission was increased in diabetic patients, and both features were accentuated in patients with poor glycemic control. Furthermore, leukocyte rolling flux rose in parallel to HbA1c levels. The induction of leukocyte-endothelial interactions in diabetic patients was related to reduced mitochondrial fusion and higher mitochondrial fission. Our findings suggest that mitochondrial dynamics could be influenced by glycemic control in leukocytes of diabetic patients, in which there is decreased mitochondrial fusion and elevated fission related to enhanced leukocyte-endothelial interactions. These findings lead to the hypothesis that poor glycemic control during T2D may alter mitochondrial dynamics and could eventually promote leukocyte-endothelial interactions and the onset of cardiovascular diseases
publishDate	2016
dc.date.none.fl_str_mv	2016 2026 2026 info
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/10366/169703
url	http://hdl.handle.net/10366/169703
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	PI12/1984 PI13/1025 PI13/0073 PI15/1424 CB06/04/0071 PROMETEOII2014/035
dc.rights.none.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/embargoedAccess
rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv	embargoedAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca instname:Universidad de Salamanca (USAL)
instname_str	Universidad de Salamanca (USAL)
reponame_str	GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection	GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Are Mitochondrial Fusion and Fission Impaired in Leukocytes of Type 2 Diabetic Patients?

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