Adventitial histopathological changes after coronary stenting in a porcine model
[EN] The adverse long-term events in first-generation drug-eluting stents were associated with chronic inflammatory response to the polymer. As an alternative, stents with biodegradable polymers emerged, whose effects on the vascular response are not yet fully known. Our objectives were to study the...
| Autores: | , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2020 |
| País: | España |
| Recursos: | Universidad de León |
| Repositorio: | BULERIA. Repositorio Institucional de la Universidad de León |
| OAI Identifier: | oai:buleria.unileon.es:10612/26698 |
| Acesso em linha: | https://vetmed.agriculturejournals.cz/artkey/vet-202011-0001_adventitial-histopathological-changes-after-coronary-stenting-in-8239-a-porcine-model.php https://hdl.handle.net/10612/26698 |
| Access Level: | acceso abierto |
| Palavra-chave: | Sanidad animal Veterinaria Adventitia Pig Polymer Restenosis Stent 3109 Ciencias Veterinarias 3109.07 Patología 2401.10 Histología Animal 3205.01 Cardiología |
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Adventitial histopathological changes after coronary stenting in a porcine modelPérez Martínez, ClaudiaPérez de Prado, ArmandoCaballero Manso, VanesaRegueiro Purriños, Marta MaríaGarnica García, María Gracia deCuellas Ramón, CarlosGonzalo Orden, José ManuelLópez Benito, MaríaRodríguez-Altónaga Martínez, José AntonioBenito Gómez, TomásFernández Vázquez, FelipeSanidad animalVeterinariaAdventitiaPigPolymerRestenosisStent3109 Ciencias Veterinarias3109.07 Patología2401.10 Histología Animal3205.01 Cardiología[EN] The adverse long-term events in first-generation drug-eluting stents were associated with chronic inflammatory response to the polymer. As an alternative, stents with biodegradable polymers emerged, whose effects on the vascular response are not yet fully known. Our objectives were to study the adventitial response to the stent implantation and the role of the polymeric vehicle. A histological (Haematoxylin-Eosin, Verhoeff van Gieson) and immunohistochemical (von Willebrand factor, alpha-smooth muscle actin) analysis were performed on resin-embedded arterial sections from fifteen Large White pigs, 28 days after the random implantation in the coronary arteries of: a chromium-cobalt stent and a stent coated with a permanent polyacrylate or biodegradable poly(d,l)lactic-co-glycolic polymer, the two latter ones are loaded with sirolimus. Independent of the stent, the adventitial inflammation was associated with the adventitial area (P = 0.006 8) and the inflammation score (P = 0.037 1); and the adventitial actin-positive cells with the vascular damage (P = 0.001 2). A significant relationship was observed between the greater percentages of the restenosis and the more intense inflammation (P = 0.035 1) and the actin-positive cells (P = 0.011 9) in the adventitia. The polymeric vehicle increased the adventitial actin-positive cells (P = 0.018), independent of the type of polymer. The adventitial changes seem to be related to the restenosic process 28 days after the coronary stenting. Further investigations are necessary to confirm the role of the polymeric vehicle on the adventitial histopathological changesSICzech Academy of Agricultural SciencesSanidad AnimalFacultad de Veterinaria2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://vetmed.agriculturejournals.cz/artkey/vet-202011-0001_adventitial-histopathological-changes-after-coronary-stenting-in-8239-a-porcine-model.phphttps://hdl.handle.net/10612/26698reponame:BULERIA. Repositorio Institucional de la Universidad de Leóninstname:Universidad de LeónIngléshttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:buleria.unileon.es:10612/266982026-06-24T12:43:27Z |
| dc.title.none.fl_str_mv |
Adventitial histopathological changes after coronary stenting in a porcine model |
| title |
Adventitial histopathological changes after coronary stenting in a porcine model |
| spellingShingle |
Adventitial histopathological changes after coronary stenting in a porcine model Pérez Martínez, Claudia Sanidad animal Veterinaria Adventitia Pig Polymer Restenosis Stent 3109 Ciencias Veterinarias 3109.07 Patología 2401.10 Histología Animal 3205.01 Cardiología |
| title_short |
Adventitial histopathological changes after coronary stenting in a porcine model |
| title_full |
Adventitial histopathological changes after coronary stenting in a porcine model |
| title_fullStr |
Adventitial histopathological changes after coronary stenting in a porcine model |
| title_full_unstemmed |
Adventitial histopathological changes after coronary stenting in a porcine model |
| title_sort |
Adventitial histopathological changes after coronary stenting in a porcine model |
| dc.creator.none.fl_str_mv |
Pérez Martínez, Claudia Pérez de Prado, Armando Caballero Manso, Vanesa Regueiro Purriños, Marta María Garnica García, María Gracia de Cuellas Ramón, Carlos Gonzalo Orden, José Manuel López Benito, María Rodríguez-Altónaga Martínez, José Antonio Benito Gómez, Tomás Fernández Vázquez, Felipe |
| author |
Pérez Martínez, Claudia |
| author_facet |
Pérez Martínez, Claudia Pérez de Prado, Armando Caballero Manso, Vanesa Regueiro Purriños, Marta María Garnica García, María Gracia de Cuellas Ramón, Carlos Gonzalo Orden, José Manuel López Benito, María Rodríguez-Altónaga Martínez, José Antonio Benito Gómez, Tomás Fernández Vázquez, Felipe |
| author_role |
author |
| author2 |
Pérez de Prado, Armando Caballero Manso, Vanesa Regueiro Purriños, Marta María Garnica García, María Gracia de Cuellas Ramón, Carlos Gonzalo Orden, José Manuel López Benito, María Rodríguez-Altónaga Martínez, José Antonio Benito Gómez, Tomás Fernández Vázquez, Felipe |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Sanidad Animal Facultad de Veterinaria |
| dc.subject.none.fl_str_mv |
Sanidad animal Veterinaria Adventitia Pig Polymer Restenosis Stent 3109 Ciencias Veterinarias 3109.07 Patología 2401.10 Histología Animal 3205.01 Cardiología |
| topic |
Sanidad animal Veterinaria Adventitia Pig Polymer Restenosis Stent 3109 Ciencias Veterinarias 3109.07 Patología 2401.10 Histología Animal 3205.01 Cardiología |
| description |
[EN] The adverse long-term events in first-generation drug-eluting stents were associated with chronic inflammatory response to the polymer. As an alternative, stents with biodegradable polymers emerged, whose effects on the vascular response are not yet fully known. Our objectives were to study the adventitial response to the stent implantation and the role of the polymeric vehicle. A histological (Haematoxylin-Eosin, Verhoeff van Gieson) and immunohistochemical (von Willebrand factor, alpha-smooth muscle actin) analysis were performed on resin-embedded arterial sections from fifteen Large White pigs, 28 days after the random implantation in the coronary arteries of: a chromium-cobalt stent and a stent coated with a permanent polyacrylate or biodegradable poly(d,l)lactic-co-glycolic polymer, the two latter ones are loaded with sirolimus. Independent of the stent, the adventitial inflammation was associated with the adventitial area (P = 0.006 8) and the inflammation score (P = 0.037 1); and the adventitial actin-positive cells with the vascular damage (P = 0.001 2). A significant relationship was observed between the greater percentages of the restenosis and the more intense inflammation (P = 0.035 1) and the actin-positive cells (P = 0.011 9) in the adventitia. The polymeric vehicle increased the adventitial actin-positive cells (P = 0.018), independent of the type of polymer. The adventitial changes seem to be related to the restenosic process 28 days after the coronary stenting. Further investigations are necessary to confirm the role of the polymeric vehicle on the adventitial histopathological changes |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://vetmed.agriculturejournals.cz/artkey/vet-202011-0001_adventitial-histopathological-changes-after-coronary-stenting-in-8239-a-porcine-model.php https://hdl.handle.net/10612/26698 |
| url |
https://vetmed.agriculturejournals.cz/artkey/vet-202011-0001_adventitial-histopathological-changes-after-coronary-stenting-in-8239-a-porcine-model.php https://hdl.handle.net/10612/26698 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.rights.none.fl_str_mv |
http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Czech Academy of Agricultural Sciences |
| publisher.none.fl_str_mv |
Czech Academy of Agricultural Sciences |
| dc.source.none.fl_str_mv |
reponame:BULERIA. Repositorio Institucional de la Universidad de León instname:Universidad de León |
| instname_str |
Universidad de León |
| reponame_str |
BULERIA. Repositorio Institucional de la Universidad de León |
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BULERIA. Repositorio Institucional de la Universidad de León |
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15,811543 |