Glial and neuronal markers in cerebrospinal fluid in different types of multiple sclerosis

In the present study, CSF concentrations of NFL, t-tau, p-tau, GFAP, S-100B, YKL-40, MCP-1, alpha-sAPP, beta-sAPP, and A beta 38, A beta 40, A beta 42 were measured in 324 MS patients to test whether a correlation among the biomarkers exists and whether the profile of CSF biomarkers varies among the...

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Bibliographic Details
Authors: Mañé Martínez, M. Alba, Olsson, Bob, Bau, Laura, Matas Martín, Elisabet, Cobo Calvo, Álvaro, Andreasson, Ulf, Blennow, Kaj, Romero Pinel, Lucía María, Martínez Yélamos, Sergio, Zetterberg, Henrik
Format: article
Status:Versión aceptada para publicación
Publication Date:2016
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/128986
Online Access:https://hdl.handle.net/2445/128986
Access Level:Open access
Keyword:Esclerosi múltiple
Marcadors bioquímics
Multiple sclerosis
Biochemical markers
Description
Summary:In the present study, CSF concentrations of NFL, t-tau, p-tau, GFAP, S-100B, YKL-40, MCP-1, alpha-sAPP, beta-sAPP, and A beta 38, A beta 40, A beta 42 were measured in 324 MS patients to test whether a correlation among the biomarkers exists and whether the profile of CSF biomarkers varies among the different types of MS. The CSF concentrations of NFL were significantly higher in RRMS while CSF concentrations of GFAP were higher in PPMS. CSF concentrations of NFL correlated with YKL-40 in CIS patients while CSF concentrations of GFAP correlated with YKL-40 in RRMS patients.

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