Dikaryotic cell cycle in the phytopathogenic fungus Ustilago maydis is controlled by the DNA damage response cascade
In a large group of fungi, mating results in a dikaryon, a cell in which the two nuclei-one from each parent cell-share a single cytoplasm for a period of time without undergoing nuclear fusion. The dikaryon stage is typical in the life cycles of many fungal species primarily in the Basidiomycota, a...
| Autores: | , |
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| Formato: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2011 |
| País: | España |
| Recursos: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/338983 |
| Acesso em linha: | http://hdl.handle.net/10261/338983 |
| Access Level: | acceso abierto |
| Palavra-chave: | DNA damage response Phytopathogenic fungus Cell cycle Corn smut Ustilago maydis Virulence |
| Resumo: | In a large group of fungi, mating results in a dikaryon, a cell in which the two nuclei-one from each parent cell-share a single cytoplasm for a period of time without undergoing nuclear fusion. The dikaryon stage is typical in the life cycles of many fungal species primarily in the Basidiomycota, a large group that includes mushrooms, bracket fungi and many phytopathogenic fungi, such as the corn pathogen Ustilago maydis. Recently, we described that in U. maydis two conserved DNA-damage checkpoint kinases, Chk1 and Atr1, work together to control the dikaryon formation. However, how this pathway is activated during the dikaryon formation and how its activation/deactivation is coordinated with the different cell cycle phases is unknown. Here we propose and discuss several hypothesis to address these questions. |
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