Prognostic value of CtIP/RBBP8 expression in breast cancer

CtIP/RBBP8 is a multifunctional protein involved in transcription, DNA replication, DNA repair by homologous recombination and the G1 and G2 checkpoints. Its multiple roles are controlled by its interaction with several specific factors, including the tumor suppressor proteins BRCA1 and retinoblasto...

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Detalhes bibliográficos
Autores: Soria-Bretones, Isabel, Sáez, Carmen, Ruiz-Borrego, Manuel, Japón, Miguel A., Huertas Sánchez, Pablo
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/123180
Acesso em linha:http://hdl.handle.net/10261/123180
Access Level:acceso abierto
Palavra-chave:Breast cancer
CtIP/RBBP8
DNA repair
Retinoblastoma
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spelling Prognostic value of CtIP/RBBP8 expression in breast cancerSoria-Bretones, IsabelSáez, CarmenRuiz-Borrego, ManuelJapón, Miguel A.Huertas Sánchez, PabloBreast cancerCtIP/RBBP8DNA repairRetinoblastomaCtIP/RBBP8 is a multifunctional protein involved in transcription, DNA replication, DNA repair by homologous recombination and the G1 and G2 checkpoints. Its multiple roles are controlled by its interaction with several specific factors, including the tumor suppressor proteins BRCA1 and retinoblastoma. Both its functions and interactors point to a putative oncogenic potential of CtIP/RBBP8 loss. However, CtIP/RBBP8 relevance in breast tumor appearance, development, and prognosis has yet to be established. We performed a retrospective analysis of CtIP/RBBP8 and RB1 levels by immunohistochemistry using 384 paraffin-embedded breast cancer biopsies obtained during tumor removal surgery. We have observed that low or no expression of CtIP/RBBP8 correlates with high-grade breast cancer and with nodal metastasis. Reduction on CtIP/RBBP8 is most common in hormone receptor (HR)-negative, HER2-positive, and basal-like tumors. We observed lower levels of RB1 on those tumors with reduced CtIP/RBBP8 levels. On luminal tumors, decreased but not absence of CtIP/RBBP8 levels correlate with increased disease-free survival when treated with a combination of hormone, radio, and chemo therapies. © 2013 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.This work has been funded by a R+D+I grant from the Spanish Ministry of Economy and Competitivity (SAF2010-14877) and a European Research Council Starting Grant (DSBRECA). C. S. is supported by a contract of Nicolas Monardes program, and M. A. J. by grant AI2013-A-0006, Consejerıa de Salud, Junta de AndalucíaPeer ReviewedJohn Wiley & SonsMinisterio de Economía y Competitividad (España)European CommissionFundación Pública Andaluza para la Investigación Biosanitaria de Andalucía OrientalJunta de AndalucíaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2015201520132015info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/123180reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1002/cam4.141Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1231802026-05-22T06:33:51Z
dc.title.none.fl_str_mv Prognostic value of CtIP/RBBP8 expression in breast cancer
title Prognostic value of CtIP/RBBP8 expression in breast cancer
spellingShingle Prognostic value of CtIP/RBBP8 expression in breast cancer
Soria-Bretones, Isabel
Breast cancer
CtIP/RBBP8
DNA repair
Retinoblastoma
title_short Prognostic value of CtIP/RBBP8 expression in breast cancer
title_full Prognostic value of CtIP/RBBP8 expression in breast cancer
title_fullStr Prognostic value of CtIP/RBBP8 expression in breast cancer
title_full_unstemmed Prognostic value of CtIP/RBBP8 expression in breast cancer
title_sort Prognostic value of CtIP/RBBP8 expression in breast cancer
dc.creator.none.fl_str_mv Soria-Bretones, Isabel
Sáez, Carmen
Ruiz-Borrego, Manuel
Japón, Miguel A.
Huertas Sánchez, Pablo
author Soria-Bretones, Isabel
author_facet Soria-Bretones, Isabel
Sáez, Carmen
Ruiz-Borrego, Manuel
Japón, Miguel A.
Huertas Sánchez, Pablo
author_role author
author2 Sáez, Carmen
Ruiz-Borrego, Manuel
Japón, Miguel A.
Huertas Sánchez, Pablo
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
European Commission
Fundación Pública Andaluza para la Investigación Biosanitaria de Andalucía Oriental
Junta de Andalucía
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Breast cancer
CtIP/RBBP8
DNA repair
Retinoblastoma
topic Breast cancer
CtIP/RBBP8
DNA repair
Retinoblastoma
description CtIP/RBBP8 is a multifunctional protein involved in transcription, DNA replication, DNA repair by homologous recombination and the G1 and G2 checkpoints. Its multiple roles are controlled by its interaction with several specific factors, including the tumor suppressor proteins BRCA1 and retinoblastoma. Both its functions and interactors point to a putative oncogenic potential of CtIP/RBBP8 loss. However, CtIP/RBBP8 relevance in breast tumor appearance, development, and prognosis has yet to be established. We performed a retrospective analysis of CtIP/RBBP8 and RB1 levels by immunohistochemistry using 384 paraffin-embedded breast cancer biopsies obtained during tumor removal surgery. We have observed that low or no expression of CtIP/RBBP8 correlates with high-grade breast cancer and with nodal metastasis. Reduction on CtIP/RBBP8 is most common in hormone receptor (HR)-negative, HER2-positive, and basal-like tumors. We observed lower levels of RB1 on those tumors with reduced CtIP/RBBP8 levels. On luminal tumors, decreased but not absence of CtIP/RBBP8 levels correlate with increased disease-free survival when treated with a combination of hormone, radio, and chemo therapies. © 2013 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
publishDate 2013
dc.date.none.fl_str_mv 2013
2015
2015
2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/123180
url http://hdl.handle.net/10261/123180
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1002/cam4.141
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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