Blood Neutrophil Counts Define Specific Clusters of Bronchiectasis Patients

We sought to investigate differential phenotypic characteristics according to neutrophil counts, using a biostatistics approach in a large-cohort study from the Spanish Online Bronchiectasis Registry (RIBRON). The 1034 patients who met the inclusion criteria were clustered into two groups on the bas...

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Bibliographic Details
Authors: Wang, Xuejie|||0000-0003-1398-3942, Olveira, Casilda|||0000-0002-6912-7400, Girón, Rosa|||0000-0001-7094-0848, García Clemente, Marta|||0000-0003-0463-5946, Maíz Carro, Luis|||0000-0003-0547-6238, Sibila, Oriol|||0000-0002-4833-6713, Golpe, Rafael|||0000-0002-3759-5322, Menéndez, Rosario, Rodríguez López, Juan|||0000-0003-0089-9768, Prados, Concepción, Martínez García, Miguel Ángel|||0000-0002-7321-1891, Rodriguez Hermosa, Juan Luis|||0000-0003-0552-2484, de la Rosa Carrillo, David|||0000-0003-0753-1771, Qin, Liyun, Duran-Jordà, Xavier|||0000-0001-8517-9254, Garcia-Ojalvo, Jordi|||0000-0002-3716-7520, Barreiro, Esther|||0000-0003-2708-3443
Format: article
Publication Date:2022
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:272212
Online Access:https://ddd.uab.cat/record/272212
https://dx.doi.org/urn:doi:10.3390/biomedicines10051044
Access Level:Open access
Keyword:Biostatistics analyses
Bronchiectasis
Bronchiectasis severity scores
Clinical outcomes
Multivariate analyses
Neutrophilic inflammation
Phenotypic clusters
Description
Summary:We sought to investigate differential phenotypic characteristics according to neutrophil counts, using a biostatistics approach in a large-cohort study from the Spanish Online Bronchiectasis Registry (RIBRON). The 1034 patients who met the inclusion criteria were clustered into two groups on the basis of their blood neutrophil levels. Using the Mann-Whitney U test to explore potential differences according to FACED and EFACED scores between the two groups, a neutrophil count of 4990 cells/µL yielded the most balanced cluster sizes: (1) above-threshold (n = 337) and (2) below-threshold (n = 697) groups. Patients above the threshold showed significantly worse lung function parameters and nutritional status, while systemic inflammation levels were higher than in the below-threshold patients. In the latter group, the proportions of patients with mild disease were greater, while a more severe disease was present in the above-threshold patients. According to the blood neutrophil counts using biostatistics analyses, two distinct clinical phenotypes of stable patients with non-CF bronchiectasis were defined. Patients falling into the above-threshold cluster were more severe. Severity was characterized by a significantly impaired lung function parameters and nutritional status, and greater systemic inflammation. Phenotypic profiles of bronchiectasis patients are well defined as a result of the cluster analysis of combined systemic and respiratory variables.

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