The NRF2 transcription factor plays a dual role in colorectal cancer: A systematic review

[EN] Colorectal cancer is one of the most common cancers worldwide, and is influenced by the interplay of various factors, including a very strong genetic component. For instance, incorrect mitochondrial biogenesis is correlated with increased risk of developing colorectal cancer. Thus, it is import...

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Detalles Bibliográficos
Autores: Gonzalez Donquiles, C., Alonso Molero, J, Fernández Villa, Tania, Vilorio Marques, L., Molina de la Torre, Antonio José, Martín Sánchez, Vicente
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Universidad de León
Repositorio:BULERIA. Repositorio Institucional de la Universidad de León
OAI Identifier:oai:buleria.unileon.es:10612/22359
Acceso en línea:https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177549
https://hdl.handle.net/10612/22359
Access Level:acceso abierto
Palabra clave:Medicina. Salud
colorectal cancer
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spelling The NRF2 transcription factor plays a dual role in colorectal cancer: A systematic reviewGonzalez Donquiles, C.Alonso Molero, JFernández Villa, TaniaVilorio Marques, L.Molina de la Torre, Antonio JoséMartín Sánchez, VicenteMedicina. Saludcolorectal cancer[EN] Colorectal cancer is one of the most common cancers worldwide, and is influenced by the interplay of various factors, including a very strong genetic component. For instance, incorrect mitochondrial biogenesis is correlated with increased risk of developing colorectal cancer. Thus, it is important to understand the consequences of changes in both the expression and the correct function of the transcription factors that regulate mitochondrial biogenesis, namely NRF2.The main objective of this paper is to characterise the relationship between NRF2 and colorectal cancer by compiling data from an exhaustive literature search. Information was obtained by defining specific search terms and searching in several databases. After a strict selection procedure, data were tabulated and the relationships between articles were assessed by measuring heterogeneity and by constructing conceptual maps.The proper basal function of NRF2 and Keap1 are essential for preventing oncogenic processes in the colon. Consequently, any disruption to the expression of these genes can promote the genesis and progression of colon cancer.SIPublic Library of ScienceMedicina PreventivaFacultad de Ciencias de la Salud2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177549https://hdl.handle.net/10612/22359reponame:BULERIA. Repositorio Institucional de la Universidad de Leóninstname:Universidad de LeónIngléshttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:buleria.unileon.es:10612/223592026-06-24T12:43:27Z
dc.title.none.fl_str_mv The NRF2 transcription factor plays a dual role in colorectal cancer: A systematic review
title The NRF2 transcription factor plays a dual role in colorectal cancer: A systematic review
spellingShingle The NRF2 transcription factor plays a dual role in colorectal cancer: A systematic review
Gonzalez Donquiles, C.
Medicina. Salud
colorectal cancer
title_short The NRF2 transcription factor plays a dual role in colorectal cancer: A systematic review
title_full The NRF2 transcription factor plays a dual role in colorectal cancer: A systematic review
title_fullStr The NRF2 transcription factor plays a dual role in colorectal cancer: A systematic review
title_full_unstemmed The NRF2 transcription factor plays a dual role in colorectal cancer: A systematic review
title_sort The NRF2 transcription factor plays a dual role in colorectal cancer: A systematic review
dc.creator.none.fl_str_mv Gonzalez Donquiles, C.
Alonso Molero, J
Fernández Villa, Tania
Vilorio Marques, L.
Molina de la Torre, Antonio José
Martín Sánchez, Vicente
author Gonzalez Donquiles, C.
author_facet Gonzalez Donquiles, C.
Alonso Molero, J
Fernández Villa, Tania
Vilorio Marques, L.
Molina de la Torre, Antonio José
Martín Sánchez, Vicente
author_role author
author2 Alonso Molero, J
Fernández Villa, Tania
Vilorio Marques, L.
Molina de la Torre, Antonio José
Martín Sánchez, Vicente
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Medicina Preventiva
Facultad de Ciencias de la Salud
dc.subject.none.fl_str_mv Medicina. Salud
colorectal cancer
topic Medicina. Salud
colorectal cancer
description [EN] Colorectal cancer is one of the most common cancers worldwide, and is influenced by the interplay of various factors, including a very strong genetic component. For instance, incorrect mitochondrial biogenesis is correlated with increased risk of developing colorectal cancer. Thus, it is important to understand the consequences of changes in both the expression and the correct function of the transcription factors that regulate mitochondrial biogenesis, namely NRF2.The main objective of this paper is to characterise the relationship between NRF2 and colorectal cancer by compiling data from an exhaustive literature search. Information was obtained by defining specific search terms and searching in several databases. After a strict selection procedure, data were tabulated and the relationships between articles were assessed by measuring heterogeneity and by constructing conceptual maps.The proper basal function of NRF2 and Keap1 are essential for preventing oncogenic processes in the colon. Consequently, any disruption to the expression of these genes can promote the genesis and progression of colon cancer.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177549
https://hdl.handle.net/10612/22359
url https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177549
https://hdl.handle.net/10612/22359
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:BULERIA. Repositorio Institucional de la Universidad de León
instname:Universidad de León
instname_str Universidad de León
reponame_str BULERIA. Repositorio Institucional de la Universidad de León
collection BULERIA. Repositorio Institucional de la Universidad de León
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repository.mail.fl_str_mv
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