Impact of geometric and hemodynamic changes on a mechanobiological model of atherosclerosis

Background and objective: in this work, the analysis of the importance of hemodynamic updates on a mechanobiological model of atheroma plaque formation is proposed. Methods: for that, we use an idealized and axisymmetric model of carotid artery. In addition, the behavior of endothelial cells dependi...

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Authors: Hernández-López, Patricia, Cilla, Myriam, Martínez, Miguel Ángel, Peña, Estefanía, Malvè, Mauro
Format: article
Status:Published version
Publication Date:2024
Country:España
Institution:Universidad Pública de Navarra
Repository:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/52131
Online Access:https://hdl.handle.net/2454/52131
Access Level:Open access
Keyword:2D-axisymmetric model
Atherosclerosis
Carotid artery
Double stenosis phenomenon
Geometry and hemodynamic changes
Three pore model
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spelling Impact of geometric and hemodynamic changes on a mechanobiological model of atherosclerosisHernández-López, PatriciaCilla, MyriamMartínez, Miguel ÁngelPeña, EstefaníaMalvè, Mauro2D-axisymmetric modelAtherosclerosisCarotid arteryDouble stenosis phenomenonGeometry and hemodynamic changesThree pore modelBackground and objective: in this work, the analysis of the importance of hemodynamic updates on a mechanobiological model of atheroma plaque formation is proposed. Methods: for that, we use an idealized and axisymmetric model of carotid artery. In addition, the behavior of endothelial cells depending on hemodynamical changes is analyzed too. A total of three computational simulations are carried out and their results are compared: an uncoupled model and two models that consider the opposite behavior of endothelial cells caused by hemodynamic changes. The model considers transient blood flow using the Navier-Stokes equation. Plasma flow across the endothelium is determined with Darcy's law and the Kedem-Katchalsky equations, considering the three-pore model, which is also employed for the flow of substances across the endothelium. The behavior of the considered substances in the arterial wall is modeled with convection¿diffusion¿reaction equations, and the arterial wall is modeled as a hyperelastic Yeoh's material. Results: significant variations are noted in both the morphology and stenosis ratio of the plaques when comparing the uncoupled model to the two models incorporating updates for geometry and hemodynamic stimuli. Besides, the phenomenon of double-stenosis is naturally reproduced in the models that consider both geometric and hemodynamical changes due to plaque growth, whereas it cannot be predicted in the uncoupled model. Conclusions: the findings indicate that integrating the plaque growth model with geometric and hemodynamic settings is essential in determining the ultimate shape and dimensions of the carotid plaque.Support was obtained from the Spanish Ministry of Science and Technology through the research projects PID2019-107517RB-I00 and PID2022-140219OB-I00 and financial support to P. Hernández-López from the grant BES-2017-080239, and the regional Government of Aragón support for the funding of the research project T24-20R. Myriam Cilla is supported by Grant Ramón Cajal grant 171562 funded by MICIU/AEI/ 10.13039/501100011033 and the European Social Fund Plus (FSE+) . M. Malvé is supported by grant PID2021-125731OB-C31 from the Spanish Ministry of Science and Innovation MCIN/AEI/10.13039/501100011033/ and FEDER ("Away to build Europe").; The authors thank the research support from the CIBER initiative, whose actions are financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund .ElsevierIngenieríaIngeniaritza2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2454/52131reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglésinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-107517RB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-140219OB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-125731OB-C31© 2024 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC license.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/521312026-06-17T12:41:47Z
dc.title.none.fl_str_mv Impact of geometric and hemodynamic changes on a mechanobiological model of atherosclerosis
title Impact of geometric and hemodynamic changes on a mechanobiological model of atherosclerosis
spellingShingle Impact of geometric and hemodynamic changes on a mechanobiological model of atherosclerosis
Hernández-López, Patricia
2D-axisymmetric model
Atherosclerosis
Carotid artery
Double stenosis phenomenon
Geometry and hemodynamic changes
Three pore model
title_short Impact of geometric and hemodynamic changes on a mechanobiological model of atherosclerosis
title_full Impact of geometric and hemodynamic changes on a mechanobiological model of atherosclerosis
title_fullStr Impact of geometric and hemodynamic changes on a mechanobiological model of atherosclerosis
title_full_unstemmed Impact of geometric and hemodynamic changes on a mechanobiological model of atherosclerosis
title_sort Impact of geometric and hemodynamic changes on a mechanobiological model of atherosclerosis
dc.creator.none.fl_str_mv Hernández-López, Patricia
Cilla, Myriam
Martínez, Miguel Ángel
Peña, Estefanía
Malvè, Mauro
author Hernández-López, Patricia
author_facet Hernández-López, Patricia
Cilla, Myriam
Martínez, Miguel Ángel
Peña, Estefanía
Malvè, Mauro
author_role author
author2 Cilla, Myriam
Martínez, Miguel Ángel
Peña, Estefanía
Malvè, Mauro
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ingeniería
Ingeniaritza
dc.subject.none.fl_str_mv 2D-axisymmetric model
Atherosclerosis
Carotid artery
Double stenosis phenomenon
Geometry and hemodynamic changes
Three pore model
topic 2D-axisymmetric model
Atherosclerosis
Carotid artery
Double stenosis phenomenon
Geometry and hemodynamic changes
Three pore model
description Background and objective: in this work, the analysis of the importance of hemodynamic updates on a mechanobiological model of atheroma plaque formation is proposed. Methods: for that, we use an idealized and axisymmetric model of carotid artery. In addition, the behavior of endothelial cells depending on hemodynamical changes is analyzed too. A total of three computational simulations are carried out and their results are compared: an uncoupled model and two models that consider the opposite behavior of endothelial cells caused by hemodynamic changes. The model considers transient blood flow using the Navier-Stokes equation. Plasma flow across the endothelium is determined with Darcy's law and the Kedem-Katchalsky equations, considering the three-pore model, which is also employed for the flow of substances across the endothelium. The behavior of the considered substances in the arterial wall is modeled with convection¿diffusion¿reaction equations, and the arterial wall is modeled as a hyperelastic Yeoh's material. Results: significant variations are noted in both the morphology and stenosis ratio of the plaques when comparing the uncoupled model to the two models incorporating updates for geometry and hemodynamic stimuli. Besides, the phenomenon of double-stenosis is naturally reproduced in the models that consider both geometric and hemodynamical changes due to plaque growth, whereas it cannot be predicted in the uncoupled model. Conclusions: the findings indicate that integrating the plaque growth model with geometric and hemodynamic settings is essential in determining the ultimate shape and dimensions of the carotid plaque.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/52131
url https://hdl.handle.net/2454/52131
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-107517RB-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-140219OB-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-125731OB-C31
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname:Universidad Pública de Navarra
instname_str Universidad Pública de Navarra
reponame_str Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
collection Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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