Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: Findings from the Los Angeles-Shanghai bladder case-control study

Genome-wide association studies have associated common variations at chromosomes 5p15 and 15q25 with lung cancer risk. The 5p15 locus has also been associated with increased bladder cancer risk in a recent report. The 15q25 locus has been associated with nicotine dependence and self-reported number...

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Detalles Bibliográficos
Autores: Gago Dominguez, Manuela, Jiang, X,, Conti, D.V,, Castelao Fernández, José Esteban, Stern, M.C., Cortessis, M.C., Pike, M.C,, Xiang, Y.-B, Gao, Y.-T,, Yuan, J.-M,, van den Berg, D.J,
Tipo de recurso: artículo
Fecha de publicación:2011
País:España
Institución:Servizo Galego de Saúde (SERGAS)
Repositorio:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/5778
Acceso en línea:http://hdl.handle.net/20.500.11940/5778
Access Level:acceso abierto
Palabra clave:Adenocarcinoma
Adult
Aged
Case-Control Studies
China
Chromosomes
Female
Humans
Male
Middle Aged
Pair 15
Pair 5
Polymorphism
Risk
Single Nucleotide
United States
Urinary Bladder Neoplasms
Descripción
Sumario:Genome-wide association studies have associated common variations at chromosomes 5p15 and 15q25 with lung cancer risk. The 5p15 locus has also been associated with increased bladder cancer risk in a recent report. The 15q25 locus has been associated with nicotine dependence and self-reported number of cigarettes smoked per day in some studies and it was proposed that its association with lung cancer may be mediated through differences in smoking behavior. Here, we investigated the roles of variations at 5p15 (rs401681, rs402710, rs2736098 and rs2736100) and 15q25 (rs1051730 and rs8034191) in bladder cancer etiology in two case-control studies conducted separately in Los Angeles County, CA, USA (498 cases and 588 controls) and in Shanghai, China (506 cases and 530 controls). We replicated the association between the 5p15 locus and bladder cancer among non-Hispanic whites (NHW) in Los Angeles [for rs2736100, per C allele odds ratio (OR) = 1.23; 95% confidence interval (CI), 1.02-1.48; P = 0.029] and among Chinese in Shanghai (OR = 1.22; 95% CI, 1.02-1.47; P = 0.033). Both rs1051730 and rs8034191 at 15q25 were rare among Chinese. Among NHW, a significant association was found between rs8034191 and bladder cancer which persisted after adjustment for cigarette smoking status, number of cigarettes smoked per day and number of years of smoking (per C allele OR = 1.26; 95% CI, 1.04-1.54; P = 0.017). Our results support 5p15 and 15q25 as susceptibility regions for bladder cancer risk. The Author 2010. Published by Oxford University Press. All rights reserved.

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