Targeting microglial KATP channels to treat neurodegenerative diseases: a mitochondrial issue

Neurodegeneration is a complex process involving different cell types and neurotransmitters. A common characteristic of neurodegenerative disorders is the occurrence of a neuroinflammatory reaction in which cellular processes involving glial cells, mainly microglia and astrocytes, are activated in r...

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Detalhes bibliográficos
Autores: Rodríguez Allué, Manuel José, Martínez Moreno, Martín, Ortega González, Fco. Javier, Mahy Gehenne, Josette Nicole
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/52825
Acesso em linha:https://hdl.handle.net/2445/52825
Access Level:acceso abierto
Palavra-chave:Micròglia
Canals de potassi
Malalties neurodegeneratives
Mitocondris
Microglia
Potassium channels
Neurodegenerative Diseases
Mitochondria
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spelling Targeting microglial KATP channels to treat neurodegenerative diseases: a mitochondrial issueRodríguez Allué, Manuel JoséMartínez Moreno, MartínOrtega González, Fco. JavierMahy Gehenne, Josette NicoleMicrògliaCanals de potassiMalalties neurodegenerativesMitocondrisMicrogliaPotassium channelsNeurodegenerative DiseasesMitochondriaNeurodegeneration is a complex process involving different cell types and neurotransmitters. A common characteristic of neurodegenerative disorders is the occurrence of a neuroinflammatory reaction in which cellular processes involving glial cells, mainly microglia and astrocytes, are activated in response to neuronal death. Microglia do not constitute a unique cell population but rather present a range of phenotypes closely related to the evolution of neurodegeneration. In a dynamic equilibrium with the lesion microenvironment, microglia phenotypes cover from a proinflammatory activation state to a neurotrophic one directly involved in cell repair and extracellular matrix remodeling. At each moment, the microglial phenotype is likely to depend on the diversity of signals from the environment and of its response capacity. As a consequence, microglia present a high energy demand, for which the mitochondria activity determines the microglia participation in the neurodegenerative process. As such, modulation of microglia activity by controlling microglia mitochondrial activity constitutes an innovative approach to interfere in the neurodegenerative process. In this review, we discuss the mitochondrial KATP channel as a new target to control microglia activity, avoid its toxic phenotype, and facilitate a positive disease outcome.Hindawi2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/52825Articles publicats en revistes (Ciències Fisiològiques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1155/2013/194546Oxidative Medicine and Cellular Longevity, 2013, vol. 2013, p. 194546http://dx.doi.org/10.1155/2013/194546cc-by (c) Rodríguez Allué et al., 2013http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/528252026-05-27T06:46:51Z
dc.title.none.fl_str_mv Targeting microglial KATP channels to treat neurodegenerative diseases: a mitochondrial issue
title Targeting microglial KATP channels to treat neurodegenerative diseases: a mitochondrial issue
spellingShingle Targeting microglial KATP channels to treat neurodegenerative diseases: a mitochondrial issue
Rodríguez Allué, Manuel José
Micròglia
Canals de potassi
Malalties neurodegeneratives
Mitocondris
Microglia
Potassium channels
Neurodegenerative Diseases
Mitochondria
title_short Targeting microglial KATP channels to treat neurodegenerative diseases: a mitochondrial issue
title_full Targeting microglial KATP channels to treat neurodegenerative diseases: a mitochondrial issue
title_fullStr Targeting microglial KATP channels to treat neurodegenerative diseases: a mitochondrial issue
title_full_unstemmed Targeting microglial KATP channels to treat neurodegenerative diseases: a mitochondrial issue
title_sort Targeting microglial KATP channels to treat neurodegenerative diseases: a mitochondrial issue
dc.creator.none.fl_str_mv Rodríguez Allué, Manuel José
Martínez Moreno, Martín
Ortega González, Fco. Javier
Mahy Gehenne, Josette Nicole
author Rodríguez Allué, Manuel José
author_facet Rodríguez Allué, Manuel José
Martínez Moreno, Martín
Ortega González, Fco. Javier
Mahy Gehenne, Josette Nicole
author_role author
author2 Martínez Moreno, Martín
Ortega González, Fco. Javier
Mahy Gehenne, Josette Nicole
author2_role author
author
author
dc.subject.none.fl_str_mv Micròglia
Canals de potassi
Malalties neurodegeneratives
Mitocondris
Microglia
Potassium channels
Neurodegenerative Diseases
Mitochondria
topic Micròglia
Canals de potassi
Malalties neurodegeneratives
Mitocondris
Microglia
Potassium channels
Neurodegenerative Diseases
Mitochondria
description Neurodegeneration is a complex process involving different cell types and neurotransmitters. A common characteristic of neurodegenerative disorders is the occurrence of a neuroinflammatory reaction in which cellular processes involving glial cells, mainly microglia and astrocytes, are activated in response to neuronal death. Microglia do not constitute a unique cell population but rather present a range of phenotypes closely related to the evolution of neurodegeneration. In a dynamic equilibrium with the lesion microenvironment, microglia phenotypes cover from a proinflammatory activation state to a neurotrophic one directly involved in cell repair and extracellular matrix remodeling. At each moment, the microglial phenotype is likely to depend on the diversity of signals from the environment and of its response capacity. As a consequence, microglia present a high energy demand, for which the mitochondria activity determines the microglia participation in the neurodegenerative process. As such, modulation of microglia activity by controlling microglia mitochondrial activity constitutes an innovative approach to interfere in the neurodegenerative process. In this review, we discuss the mitochondrial KATP channel as a new target to control microglia activity, avoid its toxic phenotype, and facilitate a positive disease outcome.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/52825
url https://hdl.handle.net/2445/52825
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1155/2013/194546
Oxidative Medicine and Cellular Longevity, 2013, vol. 2013, p. 194546
http://dx.doi.org/10.1155/2013/194546
dc.rights.none.fl_str_mv cc-by (c) Rodríguez Allué et al., 2013
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Rodríguez Allué et al., 2013
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hindawi
publisher.none.fl_str_mv Hindawi
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Fisiològiques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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