Lateral orbitofrontal cortex anticipates choices and integrates prior with current information

Adaptive behavior requires integrating prior with current information to anticipate upcoming events. Brain structures related to this computation should bring relevant signals from the recent past into the present. Here we report that rats can integrate the most recent prior information with sensory...

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Detalles Bibliográficos
Autores: Nogueira Mañas, Ramon, Abolafia, Juan M., Drugowitsch, Jan, Balaguer-Ballester, Emili, Sanchez-Vives, Maria V., Moreno Bote, Rubén
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/37060
Acceso en línea:http://hdl.handle.net/10230/37060
http://dx.doi.org/10.1038/ncomms14823
Access Level:acceso abierto
Palabra clave:Decision
Neural decoding
Neural encoding
Sensory processing
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spelling Lateral orbitofrontal cortex anticipates choices and integrates prior with current informationNogueira Mañas, RamonAbolafia, Juan M.Drugowitsch, JanBalaguer-Ballester, EmiliSanchez-Vives, Maria V.Moreno Bote, RubénDecisionNeural decodingNeural encodingSensory processingAdaptive behavior requires integrating prior with current information to anticipate upcoming events. Brain structures related to this computation should bring relevant signals from the recent past into the present. Here we report that rats can integrate the most recent prior information with sensory information, thereby improving behavior on a perceptual decision-making task with outcome-dependent past trial history. We find that anticipatory signals in the orbitofrontal cortex about upcoming choice increase over time and are even present before stimulus onset. These neuronal signals also represent the stimulus and relevant second-order combinations of past state variables. The encoding of choice, stimulus and second-order past state variables resides, up to movement onset, in overlapping populations. The neuronal representation of choice before stimulus onset and its build-up once the stimulus is presented suggest that orbitofrontal cortex plays a role in transforming immediate prior and stimulus information into choices using a compact state-space representation.R.N. is supported by a FI-AGAUR scholarship from the Government of Catalonia. R.M.-B. is supported by PSI2013-44811-P and FLAGERA-PCIN-2015-162-C02-02 from MINECO (Spain). M.V.S.-V. is supported by BFU2014-52467-R and SlowDyn FLAGERA-PCIN-2015-162-C02-01 from MINECO. This work was supported by CERCA Programme / Generalitat de Catalunya. We thank Julio Martinez-Trujillo for comments on the manuscript.Nature Research201920192017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/37060http://dx.doi.org/10.1038/ncomms14823reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésNature Communications. 2017 Mar 24;8:14823.info:eu-repo/grantAgreement/ES/1PE/PSI2013-44811-Pinfo:eu-repo/grantAgreement/ES/1PE/PCIN-2015-162-C02-02info:eu-repo/grantAgreement/ES/1PE/BFU2014-52467-Rinfo:eu-repo/grantAgreement/ES/1PE/PCIN-2015-162-C02-01© This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/370602026-06-12T07:21:37Z
dc.title.none.fl_str_mv Lateral orbitofrontal cortex anticipates choices and integrates prior with current information
title Lateral orbitofrontal cortex anticipates choices and integrates prior with current information
spellingShingle Lateral orbitofrontal cortex anticipates choices and integrates prior with current information
Nogueira Mañas, Ramon
Decision
Neural decoding
Neural encoding
Sensory processing
title_short Lateral orbitofrontal cortex anticipates choices and integrates prior with current information
title_full Lateral orbitofrontal cortex anticipates choices and integrates prior with current information
title_fullStr Lateral orbitofrontal cortex anticipates choices and integrates prior with current information
title_full_unstemmed Lateral orbitofrontal cortex anticipates choices and integrates prior with current information
title_sort Lateral orbitofrontal cortex anticipates choices and integrates prior with current information
dc.creator.none.fl_str_mv Nogueira Mañas, Ramon
Abolafia, Juan M.
Drugowitsch, Jan
Balaguer-Ballester, Emili
Sanchez-Vives, Maria V.
Moreno Bote, Rubén
author Nogueira Mañas, Ramon
author_facet Nogueira Mañas, Ramon
Abolafia, Juan M.
Drugowitsch, Jan
Balaguer-Ballester, Emili
Sanchez-Vives, Maria V.
Moreno Bote, Rubén
author_role author
author2 Abolafia, Juan M.
Drugowitsch, Jan
Balaguer-Ballester, Emili
Sanchez-Vives, Maria V.
Moreno Bote, Rubén
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Decision
Neural decoding
Neural encoding
Sensory processing
topic Decision
Neural decoding
Neural encoding
Sensory processing
description Adaptive behavior requires integrating prior with current information to anticipate upcoming events. Brain structures related to this computation should bring relevant signals from the recent past into the present. Here we report that rats can integrate the most recent prior information with sensory information, thereby improving behavior on a perceptual decision-making task with outcome-dependent past trial history. We find that anticipatory signals in the orbitofrontal cortex about upcoming choice increase over time and are even present before stimulus onset. These neuronal signals also represent the stimulus and relevant second-order combinations of past state variables. The encoding of choice, stimulus and second-order past state variables resides, up to movement onset, in overlapping populations. The neuronal representation of choice before stimulus onset and its build-up once the stimulus is presented suggest that orbitofrontal cortex plays a role in transforming immediate prior and stimulus information into choices using a compact state-space representation.
publishDate 2017
dc.date.none.fl_str_mv 2017
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/37060
http://dx.doi.org/10.1038/ncomms14823
url http://hdl.handle.net/10230/37060
http://dx.doi.org/10.1038/ncomms14823
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Nature Communications. 2017 Mar 24;8:14823.
info:eu-repo/grantAgreement/ES/1PE/PSI2013-44811-P
info:eu-repo/grantAgreement/ES/1PE/PCIN-2015-162-C02-02
info:eu-repo/grantAgreement/ES/1PE/BFU2014-52467-R
info:eu-repo/grantAgreement/ES/1PE/PCIN-2015-162-C02-01
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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