Dietary Supplements Containing Oat Beta-Glucan and/or Green Coffee (Poly)phenols Showed Limited Effect in Modulating Cardiometabolic Risk Biomarkers in Overweight/Obese Patients without a Lifestyle Intervention

Obesity has reached pandemic proportions and has become a major health concern worldwide. Therefore, it is necessary to find new strategies against this condition and its associated comorbidities. Green coffee polyphenols (GCP) and oat beta-glucans (BGs) have proven their hypolipidaemic and hypoglyc...

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Autores: García Cordero, Joaquín, Mateos Briz, María Raquel, González Rámila, Susana, Seguido, Miguel A., Sierra Cinos, José Luis, Bravo, Laura, Sarriá Ruiz, Beatriz Irene
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/103907
Acesso em linha:https://hdl.handle.net/20.500.14352/103907
Access Level:acceso abierto
Palavra-chave:616-056.25
Oat beta-glucan
Green coffee hydroxycinnamates
Obesity
Lipid metabolism
Glucose homeostasis
Dietética y nutrición (Medicina)
3206 Ciencias de la Nutrición
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spelling Dietary Supplements Containing Oat Beta-Glucan and/or Green Coffee (Poly)phenols Showed Limited Effect in Modulating Cardiometabolic Risk Biomarkers in Overweight/Obese Patients without a Lifestyle InterventionGarcía Cordero, JoaquínMateos Briz, María RaquelGonzález Rámila, SusanaSeguido, Miguel A.Sierra Cinos, José LuisBravo, LauraSarriá Ruiz, Beatriz Irene616-056.25Oat beta-glucanGreen coffee hydroxycinnamatesObesityLipid metabolismGlucose homeostasisDietética y nutrición (Medicina)3206 Ciencias de la NutriciónObesity has reached pandemic proportions and has become a major health concern worldwide. Therefore, it is necessary to find new strategies against this condition and its associated comorbidities. Green coffee polyphenols (GCP) and oat beta-glucans (BGs) have proven their hypolipidaemic and hypoglycaemic effects. This study aimed to examine the effects of the long-term consumption of supplements containing GCP, BG or the novel GCP/BG combination on lipid and glucose metabolism biomarkers in overweight/obese subjects who maintained their dietary habits and physical activity, hence addressing the difficulty that this population faces in adapting to lifestyle changes. A randomised, crossover, blind trial was carried out in 29 volunteers who consumed either GCP (300 mg), BG (2.5 g) or GCP/BG (300 mg + 2.5 g) twice a day for 8 weeks. Blood samples were collected, and blood pressure and body composition were measured at the beginning and end of each intervention. Total cholesterol, triglycerides, high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), very low-density lipoprotein (VLDL-C) cholesterol, glycated haemoglobin, fasting glucose, insulin, aspartate transaminase, alanine transaminase and different hormones and adipokines were analysed. Only VLDL-C (p = 0.01) and diastolic blood pressure (p = 0.027) decreased after the intervention, especially with the BG supplement. There were no other significant changes in the analysed biomarkers. In conclusion, the regular intake of GCP, BG and GCP/BG without lifestyle changes is not an efficient strategy to improve lipid and glucose homeostasis in overweight/obese subjects.MDPIUniversidad Complutense de Madrid20232023-05-0820232023-05-08journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/103907reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)InglésengMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Not available AGL2015-69986-R EFICACIA DE NUEVOS PRODUCTOS COMBINANDO HIDROXICINAMATOS Y BETA-GLUCANOS COMO HERRAMIENTA DIETETICA FRENTE A OBESIDAD Y DISFUNCIONES ASOCIADAS (HIPERGLICEMIA Y DISLIPEMIA)open accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1039072026-06-02T12:44:21Z
dc.title.none.fl_str_mv Dietary Supplements Containing Oat Beta-Glucan and/or Green Coffee (Poly)phenols Showed Limited Effect in Modulating Cardiometabolic Risk Biomarkers in Overweight/Obese Patients without a Lifestyle Intervention
title Dietary Supplements Containing Oat Beta-Glucan and/or Green Coffee (Poly)phenols Showed Limited Effect in Modulating Cardiometabolic Risk Biomarkers in Overweight/Obese Patients without a Lifestyle Intervention
spellingShingle Dietary Supplements Containing Oat Beta-Glucan and/or Green Coffee (Poly)phenols Showed Limited Effect in Modulating Cardiometabolic Risk Biomarkers in Overweight/Obese Patients without a Lifestyle Intervention
García Cordero, Joaquín
616-056.25
Oat beta-glucan
Green coffee hydroxycinnamates
Obesity
Lipid metabolism
Glucose homeostasis
Dietética y nutrición (Medicina)
3206 Ciencias de la Nutrición
title_short Dietary Supplements Containing Oat Beta-Glucan and/or Green Coffee (Poly)phenols Showed Limited Effect in Modulating Cardiometabolic Risk Biomarkers in Overweight/Obese Patients without a Lifestyle Intervention
title_full Dietary Supplements Containing Oat Beta-Glucan and/or Green Coffee (Poly)phenols Showed Limited Effect in Modulating Cardiometabolic Risk Biomarkers in Overweight/Obese Patients without a Lifestyle Intervention
title_fullStr Dietary Supplements Containing Oat Beta-Glucan and/or Green Coffee (Poly)phenols Showed Limited Effect in Modulating Cardiometabolic Risk Biomarkers in Overweight/Obese Patients without a Lifestyle Intervention
title_full_unstemmed Dietary Supplements Containing Oat Beta-Glucan and/or Green Coffee (Poly)phenols Showed Limited Effect in Modulating Cardiometabolic Risk Biomarkers in Overweight/Obese Patients without a Lifestyle Intervention
title_sort Dietary Supplements Containing Oat Beta-Glucan and/or Green Coffee (Poly)phenols Showed Limited Effect in Modulating Cardiometabolic Risk Biomarkers in Overweight/Obese Patients without a Lifestyle Intervention
dc.creator.none.fl_str_mv García Cordero, Joaquín
Mateos Briz, María Raquel
González Rámila, Susana
Seguido, Miguel A.
Sierra Cinos, José Luis
Bravo, Laura
Sarriá Ruiz, Beatriz Irene
author García Cordero, Joaquín
author_facet García Cordero, Joaquín
Mateos Briz, María Raquel
González Rámila, Susana
Seguido, Miguel A.
Sierra Cinos, José Luis
Bravo, Laura
Sarriá Ruiz, Beatriz Irene
author_role author
author2 Mateos Briz, María Raquel
González Rámila, Susana
Seguido, Miguel A.
Sierra Cinos, José Luis
Bravo, Laura
Sarriá Ruiz, Beatriz Irene
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 616-056.25
Oat beta-glucan
Green coffee hydroxycinnamates
Obesity
Lipid metabolism
Glucose homeostasis
Dietética y nutrición (Medicina)
3206 Ciencias de la Nutrición
topic 616-056.25
Oat beta-glucan
Green coffee hydroxycinnamates
Obesity
Lipid metabolism
Glucose homeostasis
Dietética y nutrición (Medicina)
3206 Ciencias de la Nutrición
description Obesity has reached pandemic proportions and has become a major health concern worldwide. Therefore, it is necessary to find new strategies against this condition and its associated comorbidities. Green coffee polyphenols (GCP) and oat beta-glucans (BGs) have proven their hypolipidaemic and hypoglycaemic effects. This study aimed to examine the effects of the long-term consumption of supplements containing GCP, BG or the novel GCP/BG combination on lipid and glucose metabolism biomarkers in overweight/obese subjects who maintained their dietary habits and physical activity, hence addressing the difficulty that this population faces in adapting to lifestyle changes. A randomised, crossover, blind trial was carried out in 29 volunteers who consumed either GCP (300 mg), BG (2.5 g) or GCP/BG (300 mg + 2.5 g) twice a day for 8 weeks. Blood samples were collected, and blood pressure and body composition were measured at the beginning and end of each intervention. Total cholesterol, triglycerides, high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), very low-density lipoprotein (VLDL-C) cholesterol, glycated haemoglobin, fasting glucose, insulin, aspartate transaminase, alanine transaminase and different hormones and adipokines were analysed. Only VLDL-C (p = 0.01) and diastolic blood pressure (p = 0.027) decreased after the intervention, especially with the BG supplement. There were no other significant changes in the analysed biomarkers. In conclusion, the regular intake of GCP, BG and GCP/BG without lifestyle changes is not an efficient strategy to improve lipid and glucose homeostasis in overweight/obese subjects.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-05-08
2023
2023-05-08
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/103907
url https://hdl.handle.net/20.500.14352/103907
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Not available AGL2015-69986-R EFICACIA DE NUEVOS PRODUCTOS COMBINANDO HIDROXICINAMATOS Y BETA-GLUCANOS COMO HERRAMIENTA DIETETICA FRENTE A OBESIDAD Y DISFUNCIONES ASOCIADAS (HIPERGLICEMIA Y DISLIPEMIA)
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300724

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