Correlation of fatigue with other disease related and psychosocial factors in patients with rheumatoid arthritis treated with tocilizumab ACT-AXIS study

To assess the hypothesis if tocilizumab (TCZ) is effective on disease activity, and also its effect in fatigue and other clinical and psychological disease-related factors in patients with rheumatoid arthritis (RA) treated with TCZ. A 24-week, multicenter, prospective, observational study in patient...

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Autores: Corominas, H, Alegre, C, Narvaez, J, Fernandez-Cid, CM, Torrente-Segarra, V, Gomez, MR, Pan, FM, Morla, RM, Martinez, FJR, Gomez-Centeno, A, Ares, LL, Molina, RG, Gonzalez-Albo, SP, Dalmau-Carola, J, Perez-Garcia, C, Alvarez, CB, Ercole, L, Terrancle, MA
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Recursos:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p2985
Acesso em linha:https://i3pt.portalinvestigacion.com/publicaciones/2985
Access Level:acceso abierto
Palavra-chave:clinical practice
fatigue
patient-reported outcomes
rheumatoid arthritis
tocilizumab
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spelling Correlation of fatigue with other disease related and psychosocial factors in patients with rheumatoid arthritis treated with tocilizumab ACT-AXIS studyCorominas, HAlegre, CNarvaez, JFernandez-Cid, CMTorrente-Segarra, VGomez, MRPan, FMMorla, RMMartinez, FJRGomez-Centeno, AAres, LLMolina, RGGonzalez-Albo, SPDalmau-Carola, JPerez-Garcia, CAlvarez, CBErcole, LTerrancle, MAclinical practicefatiguepatient-reported outcomesrheumatoid arthritistocilizumabTo assess the hypothesis if tocilizumab (TCZ) is effective on disease activity, and also its effect in fatigue and other clinical and psychological disease-related factors in patients with rheumatoid arthritis (RA) treated with TCZ. A 24-week, multicenter, prospective, observational study in patients with moderate to severe RA receiving TCZ after failure or intolerance to disease-modifying antirheumatic drugs or tumor necrosis factor-alpha was conducted. Of the 122 patients included, 85 were evaluable for effectiveness (85% female, 51.9 +/- 12.5 years, disease duration 8.7 +/- 7.4 years). Mean change in C-reactive protein level from baseline to week 12 was -11.2 +/- 4.0 (P<.001). Mean Disease Activity Index score (DAS28) decreased from 5.5 +/- 1.0 at baseline to 2.7 +/- 1.3 (P<.001) at week 24. Mean change in Functional Assessment of Chronic Illness Therapy score was -5.4 +/- 11.2 points at week 24. Multiple regression analysis showed that the improvement in DAS28, sleep, and depression explained 56% and 47% of fatigue variance at week 12 and 24, respectively. Tocilizumab is effective in reducing disease activity and results in a clinically significant improvement in fatigue, pain, swollen joint count, morning stiffness, sleepiness, depression, and DAS28; the last 3 were specifically identified as factors explaining fatigue variance with the use of TCZ in RA patients.LIPPINCOTT WILLIAMS & WILKINS2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/2985MEDICINEISSN: 00257974ISSNe: 15365964reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p29852026-06-21T15:30:37Z
dc.title.none.fl_str_mv Correlation of fatigue with other disease related and psychosocial factors in patients with rheumatoid arthritis treated with tocilizumab ACT-AXIS study
title Correlation of fatigue with other disease related and psychosocial factors in patients with rheumatoid arthritis treated with tocilizumab ACT-AXIS study
spellingShingle Correlation of fatigue with other disease related and psychosocial factors in patients with rheumatoid arthritis treated with tocilizumab ACT-AXIS study
Corominas, H
clinical practice
fatigue
patient-reported outcomes
rheumatoid arthritis
tocilizumab
title_short Correlation of fatigue with other disease related and psychosocial factors in patients with rheumatoid arthritis treated with tocilizumab ACT-AXIS study
title_full Correlation of fatigue with other disease related and psychosocial factors in patients with rheumatoid arthritis treated with tocilizumab ACT-AXIS study
title_fullStr Correlation of fatigue with other disease related and psychosocial factors in patients with rheumatoid arthritis treated with tocilizumab ACT-AXIS study
title_full_unstemmed Correlation of fatigue with other disease related and psychosocial factors in patients with rheumatoid arthritis treated with tocilizumab ACT-AXIS study
title_sort Correlation of fatigue with other disease related and psychosocial factors in patients with rheumatoid arthritis treated with tocilizumab ACT-AXIS study
dc.creator.none.fl_str_mv Corominas, H
Alegre, C
Narvaez, J
Fernandez-Cid, CM
Torrente-Segarra, V
Gomez, MR
Pan, FM
Morla, RM
Martinez, FJR
Gomez-Centeno, A
Ares, LL
Molina, RG
Gonzalez-Albo, SP
Dalmau-Carola, J
Perez-Garcia, C
Alvarez, CB
Ercole, L
Terrancle, MA
author Corominas, H
author_facet Corominas, H
Alegre, C
Narvaez, J
Fernandez-Cid, CM
Torrente-Segarra, V
Gomez, MR
Pan, FM
Morla, RM
Martinez, FJR
Gomez-Centeno, A
Ares, LL
Molina, RG
Gonzalez-Albo, SP
Dalmau-Carola, J
Perez-Garcia, C
Alvarez, CB
Ercole, L
Terrancle, MA
author_role author
author2 Alegre, C
Narvaez, J
Fernandez-Cid, CM
Torrente-Segarra, V
Gomez, MR
Pan, FM
Morla, RM
Martinez, FJR
Gomez-Centeno, A
Ares, LL
Molina, RG
Gonzalez-Albo, SP
Dalmau-Carola, J
Perez-Garcia, C
Alvarez, CB
Ercole, L
Terrancle, MA
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv clinical practice
fatigue
patient-reported outcomes
rheumatoid arthritis
tocilizumab
topic clinical practice
fatigue
patient-reported outcomes
rheumatoid arthritis
tocilizumab
description To assess the hypothesis if tocilizumab (TCZ) is effective on disease activity, and also its effect in fatigue and other clinical and psychological disease-related factors in patients with rheumatoid arthritis (RA) treated with TCZ. A 24-week, multicenter, prospective, observational study in patients with moderate to severe RA receiving TCZ after failure or intolerance to disease-modifying antirheumatic drugs or tumor necrosis factor-alpha was conducted. Of the 122 patients included, 85 were evaluable for effectiveness (85% female, 51.9 +/- 12.5 years, disease duration 8.7 +/- 7.4 years). Mean change in C-reactive protein level from baseline to week 12 was -11.2 +/- 4.0 (P<.001). Mean Disease Activity Index score (DAS28) decreased from 5.5 +/- 1.0 at baseline to 2.7 +/- 1.3 (P<.001) at week 24. Mean change in Functional Assessment of Chronic Illness Therapy score was -5.4 +/- 11.2 points at week 24. Multiple regression analysis showed that the improvement in DAS28, sleep, and depression explained 56% and 47% of fatigue variance at week 12 and 24, respectively. Tocilizumab is effective in reducing disease activity and results in a clinically significant improvement in fatigue, pain, swollen joint count, morning stiffness, sleepiness, depression, and DAS28; the last 3 were specifically identified as factors explaining fatigue variance with the use of TCZ in RA patients.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://i3pt.portalinvestigacion.com/publicaciones/2985
url https://i3pt.portalinvestigacion.com/publicaciones/2985
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv LIPPINCOTT WILLIAMS & WILKINS
publisher.none.fl_str_mv LIPPINCOTT WILLIAMS & WILKINS
dc.source.none.fl_str_mv MEDICINE
ISSN: 00257974
ISSNe: 15365964
reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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