Female Sex Is a Risk Factor Associated with Long-Term Post-COVID Related-Symptoms but Not with COVID-19 Symptoms: The LONG-COVID-EXP-CM Multicenter Study

Fernández de las Peñas, César; Martín Guerrero, José D.; Pellicer Valero, Óscar J.; Navarro Pardo, Esperanza; Gómez Mayordomo, Víctor; Cuadrado, María L.; Arias Navalón, José Antonio; Cigarán Méndez, Margarita; Hernández Barrera, Valentín; Arendt Nielsen, Lars

Female Sex Is a Risk Factor Associated with Long-Term Post-COVID Related-Symptoms but Not with COVID-19 Symptoms: The LONG-COVID-EXP-CM Multicenter Study

This multicenter cohort study investigated the differences between coronavirus disease 2019 (COVID-19) related symptoms and post-COVID symptoms between male and female COVID-19 survivors. Clinical and hospitalization data were collected from hospital medical records in a sample of individuals recove...

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Autores:	Fernández de las Peñas, César, Martín Guerrero, José D., Pellicer Valero, Óscar J., Navarro Pardo, Esperanza, Gómez Mayordomo, Víctor, Cuadrado, María L., Arias Navalón, José Antonio, Cigarán Méndez, Margarita, Hernández Barrera, Valentín, Arendt Nielsen, Lars
Tipo de recurso:	artículo
Fecha de publicación:	2022
País:	España
Institución:	Universidad Alfonso X el Sabio
Repositorio:	Repositorio Institucional de la Universidad Alfonso X el Sabio
Idioma:	inglés
OAI Identifier:	oai:archive.uax.com:20.500.12080/29144
Acceso en línea:	https://hdl.handle.net/20.500.12080/29144
Access Level:	acceso abierto

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spelling	Female Sex Is a Risk Factor Associated with Long-Term Post-COVID Related-Symptoms but Not with COVID-19 Symptoms: The LONG-COVID-EXP-CM Multicenter StudyFernández de las Peñas, CésarMartín Guerrero, José D.Pellicer Valero, Óscar J.Navarro Pardo, EsperanzaGómez Mayordomo, VíctorCuadrado, María L.Arias Navalón, José AntonioCigarán Méndez, MargaritaHernández Barrera, ValentínArendt Nielsen, LarsThis multicenter cohort study investigated the differences between coronavirus disease 2019 (COVID-19) related symptoms and post-COVID symptoms between male and female COVID-19 survivors. Clinical and hospitalization data were collected from hospital medical records in a sample of individuals recovered from COVID-19 at five public hospitals in Spain. A predefined list of post-COVID symptoms was systematically assessed, but patients were free to report any symptom. Anxiety/depressive levels and sleep quality were also assessed. Adjusted multivariate logistic regressions were used to identify the association of sex with post-COVID related-symptoms. A total of 1969 individuals (age: 61, SD: 16 years, 46.4% women) were assessed 8.4 months after discharge. No overall significant sex differences in COVID-19 onset symptoms at hospital admission were found. Post-COVID symptoms were present in up to 60% of hospitalized COVID-19 survivors eight months after the infection. The number of post-COVID symptoms was 2.25 for females and 1.5 for males. After adjusting by all variables, female sex was associated with ¿3 post-COVID symptoms (adj OR 2.54, 95%CI 1.671¿3.865, p < 0.001), the presence of post-COVID fatigue (adj OR 1.514, 95%CI 1.040¿2.205), dyspnea (rest: adj OR 1.428, 95%CI 1.081¿1.886, exertion: adj OR 1.409, 95%CI 1.109¿1.791), pain (adj OR 1.349, 95%CI 1.059¿1.720), hair loss (adj OR 4.529, 95%CI 2.784¿7.368), ocular problems (adj OR 1.981, 95%CI 1.185¿3.312), depressive levels (adj OR 1.606, 95%CI 1.002¿2.572) and worse sleep quality (adj OR 1.634, 95%CI 1.097¿2.434). Female sex was a risk factor for the development of some long-term post-COVID symptoms including mood disorders. Healthcare systems should consider sex differences in the management of long haulers. Keywords: COVID-19; sex; female; symptoms; fatigue; post-COVID; risk factorsUAX Archive20222022-01-1420222022-01-14journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.12080/29144reponame:Repositorio Institucional de la Universidad Alfonso X el Sabioinstname:Universidad Alfonso X el SabioInglésengopen accesshttp://purl.org/coar/access_right/c_abf2CC-BYhttp://creativecommons.org/licenses/by/4.0/deed.esinfo:eu-repo/semantics/openAccessoai:archive.uax.com:20.500.12080/291442026-05-28T12:40:21Z
dc.title.none.fl_str_mv	Female Sex Is a Risk Factor Associated with Long-Term Post-COVID Related-Symptoms but Not with COVID-19 Symptoms: The LONG-COVID-EXP-CM Multicenter Study
title	Female Sex Is a Risk Factor Associated with Long-Term Post-COVID Related-Symptoms but Not with COVID-19 Symptoms: The LONG-COVID-EXP-CM Multicenter Study
spellingShingle	Female Sex Is a Risk Factor Associated with Long-Term Post-COVID Related-Symptoms but Not with COVID-19 Symptoms: The LONG-COVID-EXP-CM Multicenter Study Fernández de las Peñas, César
title_short	Female Sex Is a Risk Factor Associated with Long-Term Post-COVID Related-Symptoms but Not with COVID-19 Symptoms: The LONG-COVID-EXP-CM Multicenter Study
title_full	Female Sex Is a Risk Factor Associated with Long-Term Post-COVID Related-Symptoms but Not with COVID-19 Symptoms: The LONG-COVID-EXP-CM Multicenter Study
title_fullStr	Female Sex Is a Risk Factor Associated with Long-Term Post-COVID Related-Symptoms but Not with COVID-19 Symptoms: The LONG-COVID-EXP-CM Multicenter Study
title_full_unstemmed	Female Sex Is a Risk Factor Associated with Long-Term Post-COVID Related-Symptoms but Not with COVID-19 Symptoms: The LONG-COVID-EXP-CM Multicenter Study
title_sort	Female Sex Is a Risk Factor Associated with Long-Term Post-COVID Related-Symptoms but Not with COVID-19 Symptoms: The LONG-COVID-EXP-CM Multicenter Study
dc.creator.none.fl_str_mv	Fernández de las Peñas, César Martín Guerrero, José D. Pellicer Valero, Óscar J. Navarro Pardo, Esperanza Gómez Mayordomo, Víctor Cuadrado, María L. Arias Navalón, José Antonio Cigarán Méndez, Margarita Hernández Barrera, Valentín Arendt Nielsen, Lars
author	Fernández de las Peñas, César
author_facet	Fernández de las Peñas, César Martín Guerrero, José D. Pellicer Valero, Óscar J. Navarro Pardo, Esperanza Gómez Mayordomo, Víctor Cuadrado, María L. Arias Navalón, José Antonio Cigarán Méndez, Margarita Hernández Barrera, Valentín Arendt Nielsen, Lars
author_role	author
author2	Martín Guerrero, José D. Pellicer Valero, Óscar J. Navarro Pardo, Esperanza Gómez Mayordomo, Víctor Cuadrado, María L. Arias Navalón, José Antonio Cigarán Méndez, Margarita Hernández Barrera, Valentín Arendt Nielsen, Lars
author2_role	author author author author author author author author author
dc.contributor.none.fl_str_mv	UAX Archive
description	This multicenter cohort study investigated the differences between coronavirus disease 2019 (COVID-19) related symptoms and post-COVID symptoms between male and female COVID-19 survivors. Clinical and hospitalization data were collected from hospital medical records in a sample of individuals recovered from COVID-19 at five public hospitals in Spain. A predefined list of post-COVID symptoms was systematically assessed, but patients were free to report any symptom. Anxiety/depressive levels and sleep quality were also assessed. Adjusted multivariate logistic regressions were used to identify the association of sex with post-COVID related-symptoms. A total of 1969 individuals (age: 61, SD: 16 years, 46.4% women) were assessed 8.4 months after discharge. No overall significant sex differences in COVID-19 onset symptoms at hospital admission were found. Post-COVID symptoms were present in up to 60% of hospitalized COVID-19 survivors eight months after the infection. The number of post-COVID symptoms was 2.25 for females and 1.5 for males. After adjusting by all variables, female sex was associated with ¿3 post-COVID symptoms (adj OR 2.54, 95%CI 1.671¿3.865, p < 0.001), the presence of post-COVID fatigue (adj OR 1.514, 95%CI 1.040¿2.205), dyspnea (rest: adj OR 1.428, 95%CI 1.081¿1.886, exertion: adj OR 1.409, 95%CI 1.109¿1.791), pain (adj OR 1.349, 95%CI 1.059¿1.720), hair loss (adj OR 4.529, 95%CI 2.784¿7.368), ocular problems (adj OR 1.981, 95%CI 1.185¿3.312), depressive levels (adj OR 1.606, 95%CI 1.002¿2.572) and worse sleep quality (adj OR 1.634, 95%CI 1.097¿2.434). Female sex was a risk factor for the development of some long-term post-COVID symptoms including mood disorders. Healthcare systems should consider sex differences in the management of long haulers. Keywords: COVID-19; sex; female; symptoms; fatigue; post-COVID; risk factors
publishDate	2022
dc.date.none.fl_str_mv	2022 2022-01-14 2022 2022-01-14
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/20.500.12080/29144
url	https://hdl.handle.net/20.500.12080/29144
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 CC-BY http://creativecommons.org/licenses/by/4.0/deed.es
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 CC-BY http://creativecommons.org/licenses/by/4.0/deed.es
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:Repositorio Institucional de la Universidad Alfonso X el Sabio instname:Universidad Alfonso X el Sabio
instname_str	Universidad Alfonso X el Sabio
reponame_str	Repositorio Institucional de la Universidad Alfonso X el Sabio
collection	Repositorio Institucional de la Universidad Alfonso X el Sabio
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Female Sex Is a Risk Factor Associated with Long-Term Post-COVID Related-Symptoms but Not with COVID-19 Symptoms: The LONG-COVID-EXP-CM Multicenter Study

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