High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus

We investigated the prognostic role of high MICs for antistaphylococcal agents in patients with methicillin-sensitive Staphylococcus aureus catheter-related bloodstream infection (MSSA CRBSI). We prospectively reviewed 83 episodes from 5 centers in Spain during April 2011 June 2014 that had optimize...

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Autores: San Juan, Rafael, Viedma, Esther, Chaves, Fernando, Lalueza, Antonio, Fortún, Jesús, Loza, Elena, Pujol Rojo, Miquel, Ardanuy Tisaire, María Carmen, Morales, Isabel, Cueto, Marina de, Resino Foz, Elena, Morales Cartagena, Alejandra, Rico, Alicia, Romero, María P., Orellana, María Ángeles, López Medrano, Francisco, Fernández Ruiz, Mario, Aguado, José María
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/126909
Acceso en línea:https://hdl.handle.net/2445/126909
Access Level:acceso abierto
Palabra clave:Sang
Malalties bacterianes
Factors de risc en les malalties
Efecte dels medicaments sobre els microorganismes
Blood
Bacterial diseases
Risk factors in diseases
Effect of drugs on microorganisms
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spelling High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureusSan Juan, RafaelViedma, EstherChaves, FernandoLalueza, AntonioFortún, JesúsLoza, ElenaPujol Rojo, MiquelArdanuy Tisaire, María CarmenMorales, IsabelCueto, Marina deResino Foz, ElenaMorales Cartagena, AlejandraRico, AliciaRomero, María P.Orellana, María ÁngelesLópez Medrano, FranciscoFernández Ruiz, MarioAguado, José MaríaSangMalalties bacterianesFactors de risc en les malaltiesEfecte dels medicaments sobre els microorganismesBloodBacterial diseasesRisk factors in diseasesEffect of drugs on microorganismsWe investigated the prognostic role of high MICs for antistaphylococcal agents in patients with methicillin-sensitive Staphylococcus aureus catheter-related bloodstream infection (MSSA CRBSI). We prospectively reviewed 83 episodes from 5 centers in Spain during April 2011 June 2014 that had optimized clinical management and analyzed the relationship between E-test MICs for vancomycin, daptomycin, oxacillin, and linezolid and development of complicated bacteremia by using multivariate analysis. Complicated MSSA CRBSI occurred in 26 (31.3%) patients; MICs for vancomycin and daptomycin were higher in these patients (optimal cutoff values for predictive accuracy = 1.5 mu g/mL and 0.5 mu g/mL). High MICs for vancomycin (hazard ratio 2.4, 95% CI 1.2-5.5) and daptomycin (hazard ratio 2.4, 95% CI 1.1-5.9) were independent risk factors for development of complicated MSSA CRBSI. Our data suggest that patients with MSSA CRBSI caused by strains that have high MICs for vancomycin or daptomycin are at increased risk for complications.Centers for Disease Control and Prevention2018201820162018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfhttps://hdl.handle.net/2445/126909Articles publicats en revistes (Patologia i Terapèutica Experimental)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3201/eid2206.151709Emerging Infectious Diseases, 2016, vol. 22, num. 6, p. 1057-1066https://doi.org/10.3201/eid2206.151709, 2016info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1269092026-05-29T05:05:01Z
dc.title.none.fl_str_mv High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus
title High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus
spellingShingle High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus
San Juan, Rafael
Sang
Malalties bacterianes
Factors de risc en les malalties
Efecte dels medicaments sobre els microorganismes
Blood
Bacterial diseases
Risk factors in diseases
Effect of drugs on microorganisms
title_short High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus
title_full High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus
title_fullStr High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus
title_full_unstemmed High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus
title_sort High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus
dc.creator.none.fl_str_mv San Juan, Rafael
Viedma, Esther
Chaves, Fernando
Lalueza, Antonio
Fortún, Jesús
Loza, Elena
Pujol Rojo, Miquel
Ardanuy Tisaire, María Carmen
Morales, Isabel
Cueto, Marina de
Resino Foz, Elena
Morales Cartagena, Alejandra
Rico, Alicia
Romero, María P.
Orellana, María Ángeles
López Medrano, Francisco
Fernández Ruiz, Mario
Aguado, José María
author San Juan, Rafael
author_facet San Juan, Rafael
Viedma, Esther
Chaves, Fernando
Lalueza, Antonio
Fortún, Jesús
Loza, Elena
Pujol Rojo, Miquel
Ardanuy Tisaire, María Carmen
Morales, Isabel
Cueto, Marina de
Resino Foz, Elena
Morales Cartagena, Alejandra
Rico, Alicia
Romero, María P.
Orellana, María Ángeles
López Medrano, Francisco
Fernández Ruiz, Mario
Aguado, José María
author_role author
author2 Viedma, Esther
Chaves, Fernando
Lalueza, Antonio
Fortún, Jesús
Loza, Elena
Pujol Rojo, Miquel
Ardanuy Tisaire, María Carmen
Morales, Isabel
Cueto, Marina de
Resino Foz, Elena
Morales Cartagena, Alejandra
Rico, Alicia
Romero, María P.
Orellana, María Ángeles
López Medrano, Francisco
Fernández Ruiz, Mario
Aguado, José María
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Sang
Malalties bacterianes
Factors de risc en les malalties
Efecte dels medicaments sobre els microorganismes
Blood
Bacterial diseases
Risk factors in diseases
Effect of drugs on microorganisms
topic Sang
Malalties bacterianes
Factors de risc en les malalties
Efecte dels medicaments sobre els microorganismes
Blood
Bacterial diseases
Risk factors in diseases
Effect of drugs on microorganisms
description We investigated the prognostic role of high MICs for antistaphylococcal agents in patients with methicillin-sensitive Staphylococcus aureus catheter-related bloodstream infection (MSSA CRBSI). We prospectively reviewed 83 episodes from 5 centers in Spain during April 2011 June 2014 that had optimized clinical management and analyzed the relationship between E-test MICs for vancomycin, daptomycin, oxacillin, and linezolid and development of complicated bacteremia by using multivariate analysis. Complicated MSSA CRBSI occurred in 26 (31.3%) patients; MICs for vancomycin and daptomycin were higher in these patients (optimal cutoff values for predictive accuracy = 1.5 mu g/mL and 0.5 mu g/mL). High MICs for vancomycin (hazard ratio 2.4, 95% CI 1.2-5.5) and daptomycin (hazard ratio 2.4, 95% CI 1.1-5.9) were independent risk factors for development of complicated MSSA CRBSI. Our data suggest that patients with MSSA CRBSI caused by strains that have high MICs for vancomycin or daptomycin are at increased risk for complications.
publishDate 2016
dc.date.none.fl_str_mv 2016
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/126909
url https://hdl.handle.net/2445/126909
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3201/eid2206.151709
Emerging Infectious Diseases, 2016, vol. 22, num. 6, p. 1057-1066
https://doi.org/10.3201/eid2206.151709
dc.rights.none.fl_str_mv , 2016
info:eu-repo/semantics/openAccess
rights_invalid_str_mv , 2016
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10 p.
application/pdf
dc.publisher.none.fl_str_mv Centers for Disease Control and Prevention
publisher.none.fl_str_mv Centers for Disease Control and Prevention
dc.source.none.fl_str_mv Articles publicats en revistes (Patologia i Terapèutica Experimental)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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