Changes in mammographic density over time and the risk of breast cancer: An observational cohort study

Background: The effect of changes in mammographic density over time on the risk of breast cancer remains inconclusive. Methods: We used information from four centres of the Breast Cancer Screening Program in Spain in the period 1996-2015. We analysed individual level data from 117,388 women first sc...

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Authors: Roman, M, Sala, M, Bare, M, Posso, M, Vidal, C, Louro, J, Sanchez, M, Penalva, L, Castells, X, Buron, A, Domingo, L, Rodriguez-Arana, A, Servitja, S, Vernet, M, Andreu, X, Benito, L, Quintana, MJ, Sola-Roca, J, Prieto, M, Galceran, J, Saladie, F, Ferrer, J, Espinas, JA, Tora-Rocamora, I, Bargallo, X
Format: article
Status:Published version
Publication Date:2019
Country:España
Institution:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repository:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p2944
Online Access:https://i3pt.portalinvestigacion.com/publicaciones/2944
Access Level:Open access
Keyword:Breast neoplasms
Mass screening
Longitudinal studies
Mammographic density
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spelling Changes in mammographic density over time and the risk of breast cancer: An observational cohort studyRoman, MSala, MBare, MPosso, MVidal, CLouro, JSanchez, MPenalva, LCastells, XBuron, ADomingo, LRodriguez-Arana, AServitja, SVernet, MAndreu, XBenito, LQuintana, MJSola-Roca, JPrieto, MGalceran, JSaladie, FFerrer, JEspinas, JATora-Rocamora, IBargallo, XBreast neoplasmsMass screeningLongitudinal studiesMammographic densityBackground: The effect of changes in mammographic density over time on the risk of breast cancer remains inconclusive. Methods: We used information from four centres of the Breast Cancer Screening Program in Spain in the period 1996-2015. We analysed individual level data from 117,388 women first screened age 50-54, with at least two screening examinations. Breast density was determined using the BI-RADS classification (A to D in increasing order) at earliest and latest screening examination. Adjusted Poisson regression models were used to estimate the relative risk (RR) and 95% confidence intervals (95% CI) of the association between changes in mammographic density and breast cancer risk over time. Results: During an average 5.8 years of follow-up, 1592 (1.36%) women had a breast cancer diagnosis. An increase in density category increased breast cancer risk, and a decrease in density decreased the risk, compared with women who remained in the same BI-RADS category. Women whose density category increased from B to C or B to D had a RR of 1.55 (95% CI = 1.24-1.94) and 2.32 (95% CI = 1.48-3.63), respectively. The RR for women whose density increased from C to D was 1.51 (95% CI = 1.03-2.22). Changes in BI-RADS density were similarly associated with the risk for invasive cancer than for ductal carcinoma in situ. Conclusions: Although a modest proportion of women changed BI-RADS density category, mammographic density changes modulated the risk of breast cancer and identified women at a differential risk. Using two longitudinal measures of BI-RADS density could help target women for risk-based screening strategies. (C) 2019 Elsevier Ltd. All rights reserved.CHURCHILL LIVINGSTONE2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/2944BREASTISSN: 09609776ISSNe: 15323080reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p29442026-06-21T15:30:37Z
dc.title.none.fl_str_mv Changes in mammographic density over time and the risk of breast cancer: An observational cohort study
title Changes in mammographic density over time and the risk of breast cancer: An observational cohort study
spellingShingle Changes in mammographic density over time and the risk of breast cancer: An observational cohort study
Roman, M
Breast neoplasms
Mass screening
Longitudinal studies
Mammographic density
title_short Changes in mammographic density over time and the risk of breast cancer: An observational cohort study
title_full Changes in mammographic density over time and the risk of breast cancer: An observational cohort study
title_fullStr Changes in mammographic density over time and the risk of breast cancer: An observational cohort study
title_full_unstemmed Changes in mammographic density over time and the risk of breast cancer: An observational cohort study
title_sort Changes in mammographic density over time and the risk of breast cancer: An observational cohort study
dc.creator.none.fl_str_mv Roman, M
Sala, M
Bare, M
Posso, M
Vidal, C
Louro, J
Sanchez, M
Penalva, L
Castells, X
Buron, A
Domingo, L
Rodriguez-Arana, A
Servitja, S
Vernet, M
Andreu, X
Benito, L
Quintana, MJ
Sola-Roca, J
Prieto, M
Galceran, J
Saladie, F
Ferrer, J
Espinas, JA
Tora-Rocamora, I
Bargallo, X
author Roman, M
author_facet Roman, M
Sala, M
Bare, M
Posso, M
Vidal, C
Louro, J
Sanchez, M
Penalva, L
Castells, X
Buron, A
Domingo, L
Rodriguez-Arana, A
Servitja, S
Vernet, M
Andreu, X
Benito, L
Quintana, MJ
Sola-Roca, J
Prieto, M
Galceran, J
Saladie, F
Ferrer, J
Espinas, JA
Tora-Rocamora, I
Bargallo, X
author_role author
author2 Sala, M
Bare, M
Posso, M
Vidal, C
Louro, J
Sanchez, M
Penalva, L
Castells, X
Buron, A
Domingo, L
Rodriguez-Arana, A
Servitja, S
Vernet, M
Andreu, X
Benito, L
Quintana, MJ
Sola-Roca, J
Prieto, M
Galceran, J
Saladie, F
Ferrer, J
Espinas, JA
Tora-Rocamora, I
Bargallo, X
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Breast neoplasms
Mass screening
Longitudinal studies
Mammographic density
topic Breast neoplasms
Mass screening
Longitudinal studies
Mammographic density
description Background: The effect of changes in mammographic density over time on the risk of breast cancer remains inconclusive. Methods: We used information from four centres of the Breast Cancer Screening Program in Spain in the period 1996-2015. We analysed individual level data from 117,388 women first screened age 50-54, with at least two screening examinations. Breast density was determined using the BI-RADS classification (A to D in increasing order) at earliest and latest screening examination. Adjusted Poisson regression models were used to estimate the relative risk (RR) and 95% confidence intervals (95% CI) of the association between changes in mammographic density and breast cancer risk over time. Results: During an average 5.8 years of follow-up, 1592 (1.36%) women had a breast cancer diagnosis. An increase in density category increased breast cancer risk, and a decrease in density decreased the risk, compared with women who remained in the same BI-RADS category. Women whose density category increased from B to C or B to D had a RR of 1.55 (95% CI = 1.24-1.94) and 2.32 (95% CI = 1.48-3.63), respectively. The RR for women whose density increased from C to D was 1.51 (95% CI = 1.03-2.22). Changes in BI-RADS density were similarly associated with the risk for invasive cancer than for ductal carcinoma in situ. Conclusions: Although a modest proportion of women changed BI-RADS density category, mammographic density changes modulated the risk of breast cancer and identified women at a differential risk. Using two longitudinal measures of BI-RADS density could help target women for risk-based screening strategies. (C) 2019 Elsevier Ltd. All rights reserved.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://i3pt.portalinvestigacion.com/publicaciones/2944
url https://i3pt.portalinvestigacion.com/publicaciones/2944
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv CHURCHILL LIVINGSTONE
publisher.none.fl_str_mv CHURCHILL LIVINGSTONE
dc.source.none.fl_str_mv BREAST
ISSN: 09609776
ISSNe: 15323080
reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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