Endoglin in the spotlight to treat cáncer

A spotlight has been shone on endoglin in recent years due to that fact of its potential to serve as both a reliable disease biomarker and a therapeutic target. Indeed, endoglin has now been assigned many roles in both physiological and pathological processes. From a molecular point of view, endogli...

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Autores: González Muñoz, Teresa, Amaral, Ana Teresa, Puerto-Camacho, Pilar, Peinado, Héctor, Álava Casado, Enrique de
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/109149
Acceso en línea:https://hdl.handle.net/11441/109149
https://doi.org/10.3390/ijms22063186
Access Level:acceso abierto
Palabra clave:Endoglin
Tumor
Microenvironment
Targeted therapy
Biomarker
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spelling Endoglin in the spotlight to treat cáncerGonzález Muñoz, TeresaAmaral, Ana TeresaPuerto-Camacho, PilarPeinado, HéctorÁlava Casado, Enrique deEndoglinTumorMicroenvironmentTargeted therapyBiomarkerA spotlight has been shone on endoglin in recent years due to that fact of its potential to serve as both a reliable disease biomarker and a therapeutic target. Indeed, endoglin has now been assigned many roles in both physiological and pathological processes. From a molecular point of view, endoglin mainly acts as a co-receptor in the canonical TGFβ pathway, but also it may be shed and released from the membrane, giving rise to the soluble form, which also plays important roles in cell signaling. In cancer, in particular, endoglin may contribute to either an oncogenic or a non-oncogenic phenotype depending on the cell context. The fact that endoglin is expressed by neoplastic and non-neoplastic cells within the tumor microenvironment suggests new possibilities for targeted therapies. Here, we aimed to review and discuss the many roles played by endoglin in different tumor types, as well as the strong evidence provided by pre-clinical and clinical studies that supports the therapeutic targeting of endoglin as a novel clinical strategy.H.P. Departamento de Defensa de EE. UU. W81XWH-16-1-0131Fundación Proyecto Neurofibromatosis. T.G.M.FPU (Ministerio de Ciencia, Innovación y Universidades, Gobierno de España). Retos-Colaboración RTC-2014-2102-1 y PI17-000464 de MINECO-FEDERMDPICitología e Histología Normal y Patológica2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/109149https://doi.org/10.3390/ijms22063186reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésRevista International Journal of Molecular Sciences, 22 (6)W81XWH-16-1-0131RTC-2014-2102-1PI17-000464info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1091492026-06-17T12:51:07Z
dc.title.none.fl_str_mv Endoglin in the spotlight to treat cáncer
title Endoglin in the spotlight to treat cáncer
spellingShingle Endoglin in the spotlight to treat cáncer
González Muñoz, Teresa
Endoglin
Tumor
Microenvironment
Targeted therapy
Biomarker
title_short Endoglin in the spotlight to treat cáncer
title_full Endoglin in the spotlight to treat cáncer
title_fullStr Endoglin in the spotlight to treat cáncer
title_full_unstemmed Endoglin in the spotlight to treat cáncer
title_sort Endoglin in the spotlight to treat cáncer
dc.creator.none.fl_str_mv González Muñoz, Teresa
Amaral, Ana Teresa
Puerto-Camacho, Pilar
Peinado, Héctor
Álava Casado, Enrique de
author González Muñoz, Teresa
author_facet González Muñoz, Teresa
Amaral, Ana Teresa
Puerto-Camacho, Pilar
Peinado, Héctor
Álava Casado, Enrique de
author_role author
author2 Amaral, Ana Teresa
Puerto-Camacho, Pilar
Peinado, Héctor
Álava Casado, Enrique de
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Citología e Histología Normal y Patológica
dc.subject.none.fl_str_mv Endoglin
Tumor
Microenvironment
Targeted therapy
Biomarker
topic Endoglin
Tumor
Microenvironment
Targeted therapy
Biomarker
description A spotlight has been shone on endoglin in recent years due to that fact of its potential to serve as both a reliable disease biomarker and a therapeutic target. Indeed, endoglin has now been assigned many roles in both physiological and pathological processes. From a molecular point of view, endoglin mainly acts as a co-receptor in the canonical TGFβ pathway, but also it may be shed and released from the membrane, giving rise to the soluble form, which also plays important roles in cell signaling. In cancer, in particular, endoglin may contribute to either an oncogenic or a non-oncogenic phenotype depending on the cell context. The fact that endoglin is expressed by neoplastic and non-neoplastic cells within the tumor microenvironment suggests new possibilities for targeted therapies. Here, we aimed to review and discuss the many roles played by endoglin in different tumor types, as well as the strong evidence provided by pre-clinical and clinical studies that supports the therapeutic targeting of endoglin as a novel clinical strategy.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/109149
https://doi.org/10.3390/ijms22063186
url https://hdl.handle.net/11441/109149
https://doi.org/10.3390/ijms22063186
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Revista International Journal of Molecular Sciences, 22 (6)
W81XWH-16-1-0131
RTC-2014-2102-1
PI17-000464
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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