Negative symptoms in children and adolescents with early-onset psychosis and at clinical high-risk for psychosis: systematic review and meta-analysis

© The Author(s), 2023. Published by Cambridge University Press on behalf of the Royal College of Psychiatrists. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, di...

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Autores: Salazar de Pablo, Gonzalo, Catalán, Ana, Vaquerizo-Serrano, Julio David, Pedruzo, Borja, Alameda, Luis, Sandroni, Veronica, Armendariz, Álvaro, Rodríguez, Victoria, Arango, Celso, Moreno, Carmen, Downs, Johnny, Abbott, Chris, Shin, Jae Il, Solmi, Marco, Fusar-Poli, Paolo, Correll, Christoph U.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/353989
Acceso en línea:http://hdl.handle.net/10261/353989
Access Level:acceso abierto
Palabra clave:Early-onset psychosis
Psychotic disorders
Meta-analysis
Clinical high risk of psychosis
Prevention
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spelling Negative symptoms in children and adolescents with early-onset psychosis and at clinical high-risk for psychosis: systematic review and meta-analysisSalazar de Pablo, GonzaloCatalán, AnaVaquerizo-Serrano, Julio DavidPedruzo, BorjaAlameda, LuisSandroni, VeronicaArmendariz, ÁlvaroRodríguez, VictoriaArango, CelsoMoreno, CarmenDowns, JohnnyAbbott, ChrisShin, Jae IlSolmi, MarcoFusar-Poli, PaoloCorrell, Christoph U.Early-onset psychosisPsychotic disordersMeta-analysisClinical high risk of psychosisPrevention© The Author(s), 2023. Published by Cambridge University Press on behalf of the Royal College of Psychiatrists. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.[Background] Early-onset psychosis (EOP) refers to the development of a first episode of psychosis before 18 years of age. Individuals at clinical high risk for psychosis (CHR-P) include adolescents and young adults, although most evidence has focused on adults. Negative symptoms are important prognostic indicators in psychosis. However, research focusing on children and adolescents is limited.[Aims] To provide meta-analytical evidence and a comprehensive review of the status and advances in the diagnosis, prognosis and treatment of negative symptoms in children and adolescents with EOP and at CHR-P.[Method] PRISMA/MOOSE-compliant systematic review (PROSPERO: CRD42022360925) from inception to 18 August 2022, in any language, to identify individual studies conducted in EOP/CHR-P children and adolescents (mean age <18 years) providing findings on negative symptoms. Findings were systematically appraised. Random-effects meta-analyses were performed on the prevalence of negative symptoms, carrying out sensitivity analyses, heterogeneity analyses, publication bias assessment and quality assessment using the Newcastle–Ottawa Scale.[Results] Of 3289 articles, 133 were included (n = 6776 EOP, mean age 15.3 years (s.d. = 1.6), males = 56.1%; n = 2138 CHR-P, mean age 16.1 years (s.d. = 1.0), males = 48.6%). There were negative symptoms in 60.8% (95% CI 46.4%–75.2%) of the children and adolescents with EOP and 79.6% (95% CI 66.3–92.9%) of those at CHR-P. Prevalence and severity of negative symptoms were associated with poor clinical, functional and intervention outcomes in both groups. Different interventions were piloted, with variable results requiring further replication.[Conclusions] Negative symptoms are common in children and adolescents at early stages of psychosis, particularly in those at CHR-P, and are associated with poor outcomes. Future intervention research is required so that evidence-based treatments will become available.Peer reviewedCambridge University PressConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/353989reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1192/bjp.2022.203Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3539892026-05-22T06:33:51Z
dc.title.none.fl_str_mv Negative symptoms in children and adolescents with early-onset psychosis and at clinical high-risk for psychosis: systematic review and meta-analysis
title Negative symptoms in children and adolescents with early-onset psychosis and at clinical high-risk for psychosis: systematic review and meta-analysis
spellingShingle Negative symptoms in children and adolescents with early-onset psychosis and at clinical high-risk for psychosis: systematic review and meta-analysis
Salazar de Pablo, Gonzalo
Early-onset psychosis
Psychotic disorders
Meta-analysis
Clinical high risk of psychosis
Prevention
title_short Negative symptoms in children and adolescents with early-onset psychosis and at clinical high-risk for psychosis: systematic review and meta-analysis
title_full Negative symptoms in children and adolescents with early-onset psychosis and at clinical high-risk for psychosis: systematic review and meta-analysis
title_fullStr Negative symptoms in children and adolescents with early-onset psychosis and at clinical high-risk for psychosis: systematic review and meta-analysis
title_full_unstemmed Negative symptoms in children and adolescents with early-onset psychosis and at clinical high-risk for psychosis: systematic review and meta-analysis
title_sort Negative symptoms in children and adolescents with early-onset psychosis and at clinical high-risk for psychosis: systematic review and meta-analysis
dc.creator.none.fl_str_mv Salazar de Pablo, Gonzalo
Catalán, Ana
Vaquerizo-Serrano, Julio David
Pedruzo, Borja
Alameda, Luis
Sandroni, Veronica
Armendariz, Álvaro
Rodríguez, Victoria
Arango, Celso
Moreno, Carmen
Downs, Johnny
Abbott, Chris
Shin, Jae Il
Solmi, Marco
Fusar-Poli, Paolo
Correll, Christoph U.
author Salazar de Pablo, Gonzalo
author_facet Salazar de Pablo, Gonzalo
Catalán, Ana
Vaquerizo-Serrano, Julio David
Pedruzo, Borja
Alameda, Luis
Sandroni, Veronica
Armendariz, Álvaro
Rodríguez, Victoria
Arango, Celso
Moreno, Carmen
Downs, Johnny
Abbott, Chris
Shin, Jae Il
Solmi, Marco
Fusar-Poli, Paolo
Correll, Christoph U.
author_role author
author2 Catalán, Ana
Vaquerizo-Serrano, Julio David
Pedruzo, Borja
Alameda, Luis
Sandroni, Veronica
Armendariz, Álvaro
Rodríguez, Victoria
Arango, Celso
Moreno, Carmen
Downs, Johnny
Abbott, Chris
Shin, Jae Il
Solmi, Marco
Fusar-Poli, Paolo
Correll, Christoph U.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Early-onset psychosis
Psychotic disorders
Meta-analysis
Clinical high risk of psychosis
Prevention
topic Early-onset psychosis
Psychotic disorders
Meta-analysis
Clinical high risk of psychosis
Prevention
description © The Author(s), 2023. Published by Cambridge University Press on behalf of the Royal College of Psychiatrists. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/353989
url http://hdl.handle.net/10261/353989
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1192/bjp.2022.203
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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repository.mail.fl_str_mv
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