Opening up the DNA methylome of dementia

Dementia is a complex clinical condition characterized by several cognitive impairments that interfere with patient independence in executing everyday tasks. Various neurodegenerative disorders have dementia in common among their clinical manifestations. In addition, these diseases, such as Alzheime...

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Detalles Bibliográficos
Autores: Delgado-Morales, Raul, Esteller, Manel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/114032
Acceso en línea:https://hdl.handle.net/2445/114032
Access Level:acceso abierto
Palabra clave:Metilació
ADN
Demència
Malalties neurodegeneratives
Epigènesi
Methylation
DNA
Dementia
Neurodegenerative Diseases
Epigenesis
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repository_id_str
spelling Opening up the DNA methylome of dementiaDelgado-Morales, RaulEsteller, ManelMetilacióADNDemènciaMalalties neurodegenerativesEpigènesiMethylationDNADementiaNeurodegenerative DiseasesEpigenesisDementia is a complex clinical condition characterized by several cognitive impairments that interfere with patient independence in executing everyday tasks. Various neurodegenerative disorders have dementia in common among their clinical manifestations. In addition, these diseases, such as Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies and frontotemporal dementia, share molecular alterations at the neuropathological level. In recent years, the field of neuroepigenetics has expanded massively and it is now clear that epigenetic processes, such as DNA methylation, are mechanisms involved in both normal and pathological brain function. Despite the persistent methodological and conceptual caveats, it has been reported that several genes fundamental to the development of neurodegenerative disorders are deregulated by aberrant methylation patterns of their promoters, and even common epigenetic signatures for some dementia-associated pathologies have been identified. Therefore, understanding the epigenetic mechanisms that are altered in dementia, especially those associated with the initial phases, will allow us not only to understand the etiopathology of dementia and its progression but also to design effective therapies to reduce this global public health problem. This review provides an in-depth summary of our current knowledge about DNA methylation in dementia, focusing exclusively on the analyses performed in human brain.Nature Publishing Group2017201720172017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion12 p.application/pdfhttps://hdl.handle.net/2445/114032Articles publicats en revistes (Ciències Fisiològiques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1038/mp.2016.242Molecular Psychiatry, 2017, vol. 22, num. 4, p. 485-496https://doi.org/10.1038/mp.2016.242cc-by-nc-sa (c) Delgado-Morales, Raul; Esteller, Manel, 2017http://creativecommons.org/licenses/by-nc-sa/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1140322026-05-29T05:05:01Z
dc.title.none.fl_str_mv Opening up the DNA methylome of dementia
title Opening up the DNA methylome of dementia
spellingShingle Opening up the DNA methylome of dementia
Delgado-Morales, Raul
Metilació
ADN
Demència
Malalties neurodegeneratives
Epigènesi
Methylation
DNA
Dementia
Neurodegenerative Diseases
Epigenesis
title_short Opening up the DNA methylome of dementia
title_full Opening up the DNA methylome of dementia
title_fullStr Opening up the DNA methylome of dementia
title_full_unstemmed Opening up the DNA methylome of dementia
title_sort Opening up the DNA methylome of dementia
dc.creator.none.fl_str_mv Delgado-Morales, Raul
Esteller, Manel
author Delgado-Morales, Raul
author_facet Delgado-Morales, Raul
Esteller, Manel
author_role author
author2 Esteller, Manel
author2_role author
dc.subject.none.fl_str_mv Metilació
ADN
Demència
Malalties neurodegeneratives
Epigènesi
Methylation
DNA
Dementia
Neurodegenerative Diseases
Epigenesis
topic Metilació
ADN
Demència
Malalties neurodegeneratives
Epigènesi
Methylation
DNA
Dementia
Neurodegenerative Diseases
Epigenesis
description Dementia is a complex clinical condition characterized by several cognitive impairments that interfere with patient independence in executing everyday tasks. Various neurodegenerative disorders have dementia in common among their clinical manifestations. In addition, these diseases, such as Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies and frontotemporal dementia, share molecular alterations at the neuropathological level. In recent years, the field of neuroepigenetics has expanded massively and it is now clear that epigenetic processes, such as DNA methylation, are mechanisms involved in both normal and pathological brain function. Despite the persistent methodological and conceptual caveats, it has been reported that several genes fundamental to the development of neurodegenerative disorders are deregulated by aberrant methylation patterns of their promoters, and even common epigenetic signatures for some dementia-associated pathologies have been identified. Therefore, understanding the epigenetic mechanisms that are altered in dementia, especially those associated with the initial phases, will allow us not only to understand the etiopathology of dementia and its progression but also to design effective therapies to reduce this global public health problem. This review provides an in-depth summary of our current knowledge about DNA methylation in dementia, focusing exclusively on the analyses performed in human brain.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/114032
url https://hdl.handle.net/2445/114032
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/mp.2016.242
Molecular Psychiatry, 2017, vol. 22, num. 4, p. 485-496
https://doi.org/10.1038/mp.2016.242
dc.rights.none.fl_str_mv cc-by-nc-sa (c) Delgado-Morales, Raul; Esteller, Manel, 2017
http://creativecommons.org/licenses/by-nc-sa/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-sa (c) Delgado-Morales, Raul; Esteller, Manel, 2017
http://creativecommons.org/licenses/by-nc-sa/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12 p.
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Fisiològiques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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