Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial

The aim of this 12-week randomized, double-blind, placebo-controlled trial was to determine the efficacy and safety of a probiotic mixture in the reduction of psoriasis severity. Ninety 18?70-year-old adults with plaque psoriasis were randomized into probiotic and placebo groups. At 12-week follow-u...

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Autores: NAVARRO-LÓPEZ, Vicente, MARTÍNEZ-ANDRÉS, Asunción, Ramírez Boscá, Ana, Ruzafa-Costas, Beatriz, Núñez-Delegido, Eva, Carrión-Gutiérrez, Miguel, Prieto Merino, Antonio David, CODOÑER-CORTÉS, Francisco, Ramón Vidal, Daniel, Genovés, Salvador, Chenoll, Empar, PÉREZ-ORQUÍN, José M., Pico-Monllor, JOSE ANTONIO, Chumillas, Sara
Formato: artículo
Fecha de publicación:2019
País:España
Recursos:Universidad Miguel Hernández de Elche
Repositorio:REDIUMH. Depósito Digital de la UMH
OAI Identifier:oai:dspace.umh.es:11000/36541
Acesso em linha:https://hdl.handle.net/11000/36541
Access Level:acceso abierto
Palavra-chave:psoriasis
dermatology
probiotic
microbiome
microbiota
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spelling Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical TrialNAVARRO-LÓPEZ, VicenteMARTÍNEZ-ANDRÉS, AsunciónRamírez Boscá, AnaRuzafa-Costas, BeatrizNúñez-Delegido, EvaCarrión-Gutiérrez, MiguelPrieto Merino, Antonio DavidCODOÑER-CORTÉS, FranciscoRamón Vidal, DanielGenovés, SalvadorChenoll, EmparPÉREZ-ORQUÍN, José M.Pico-Monllor, JOSE ANTONIOChumillas, SarapsoriasisdermatologyprobioticmicrobiomemicrobiotaThe aim of this 12-week randomized, double-blind, placebo-controlled trial was to determine the efficacy and safety of a probiotic mixture in the reduction of psoriasis severity. Ninety 18?70-year-old adults with plaque psoriasis were randomized into probiotic and placebo groups. At 12-week follow-up, 66.7% of patients in the probiotic group and 41.9% in the placebo group showed a reduction in Psoriasis Area and Severity Index of at least 75% (p?<?0.05). A clinically relevant difference was observed in Physician Global Assessment index: 48.9% in the probiotic group achieved a score of 0 or 1, compared with 30.2% in the placebo group. The results of follow-up 6 months after the end of the study showed a lower risk of relapse after the intake of the probiotic mixture. Analysis of gut microbiota confirmed the efficacy of the probiotic in modulation of the microbiota composition.Medical Journals SwedenDepartamentos de la UMH::Farmacología, Pediatría y Química Orgánica202520252019info:eu-repo/semantics/articleapplication/pdf7application/pdfhttps://hdl.handle.net/11000/36541reponame:REDIUMH. Depósito Digital de la UMHinstname:Universidad Miguel Hernández de ElcheIngléshttps://doi.org/10.2340/00015555-3305info:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:dspace.umh.es:11000/365412026-05-27T13:36:21Z
dc.title.none.fl_str_mv Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial
title Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial
spellingShingle Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial
NAVARRO-LÓPEZ, Vicente
psoriasis
dermatology
probiotic
microbiome
microbiota
title_short Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial
title_full Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial
title_fullStr Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial
title_full_unstemmed Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial
title_sort Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial
dc.creator.none.fl_str_mv NAVARRO-LÓPEZ, Vicente
MARTÍNEZ-ANDRÉS, Asunción
Ramírez Boscá, Ana
Ruzafa-Costas, Beatriz
Núñez-Delegido, Eva
Carrión-Gutiérrez, Miguel
Prieto Merino, Antonio David
CODOÑER-CORTÉS, Francisco
Ramón Vidal, Daniel
Genovés, Salvador
Chenoll, Empar
PÉREZ-ORQUÍN, José M.
Pico-Monllor, JOSE ANTONIO
Chumillas, Sara
author NAVARRO-LÓPEZ, Vicente
author_facet NAVARRO-LÓPEZ, Vicente
MARTÍNEZ-ANDRÉS, Asunción
Ramírez Boscá, Ana
Ruzafa-Costas, Beatriz
Núñez-Delegido, Eva
Carrión-Gutiérrez, Miguel
Prieto Merino, Antonio David
CODOÑER-CORTÉS, Francisco
Ramón Vidal, Daniel
Genovés, Salvador
Chenoll, Empar
PÉREZ-ORQUÍN, José M.
Pico-Monllor, JOSE ANTONIO
Chumillas, Sara
author_role author
author2 MARTÍNEZ-ANDRÉS, Asunción
Ramírez Boscá, Ana
Ruzafa-Costas, Beatriz
Núñez-Delegido, Eva
Carrión-Gutiérrez, Miguel
Prieto Merino, Antonio David
CODOÑER-CORTÉS, Francisco
Ramón Vidal, Daniel
Genovés, Salvador
Chenoll, Empar
PÉREZ-ORQUÍN, José M.
Pico-Monllor, JOSE ANTONIO
Chumillas, Sara
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamentos de la UMH::Farmacología, Pediatría y Química Orgánica
dc.subject.none.fl_str_mv psoriasis
dermatology
probiotic
microbiome
microbiota
topic psoriasis
dermatology
probiotic
microbiome
microbiota
description The aim of this 12-week randomized, double-blind, placebo-controlled trial was to determine the efficacy and safety of a probiotic mixture in the reduction of psoriasis severity. Ninety 18?70-year-old adults with plaque psoriasis were randomized into probiotic and placebo groups. At 12-week follow-up, 66.7% of patients in the probiotic group and 41.9% in the placebo group showed a reduction in Psoriasis Area and Severity Index of at least 75% (p?<?0.05). A clinically relevant difference was observed in Physician Global Assessment index: 48.9% in the probiotic group achieved a score of 0 or 1, compared with 30.2% in the placebo group. The results of follow-up 6 months after the end of the study showed a lower risk of relapse after the intake of the probiotic mixture. Analysis of gut microbiota confirmed the efficacy of the probiotic in modulation of the microbiota composition.
publishDate 2019
dc.date.none.fl_str_mv 2019
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/11000/36541
url https://hdl.handle.net/11000/36541
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.2340/00015555-3305
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
7
application/pdf
dc.publisher.none.fl_str_mv Medical Journals Sweden
publisher.none.fl_str_mv Medical Journals Sweden
dc.source.none.fl_str_mv reponame:REDIUMH. Depósito Digital de la UMH
instname:Universidad Miguel Hernández de Elche
instname_str Universidad Miguel Hernández de Elche
reponame_str REDIUMH. Depósito Digital de la UMH
collection REDIUMH. Depósito Digital de la UMH
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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