Comparative analysis of microRNA profiles between adult Ascaris lumbricoides and Ascaris suum

[Background] The parasitic nematodes Ascaris lumbricoides and A. suum are of great public health and economic significance, and the two taxa were proposed to represent a single species. miRNAs are known with functions of gene regulations at post-transcriptional level.

Detalles Bibliográficos
Autores: Shao, Chang-Chun, Xu, Min-Jun, Alasaad, Samer, Song, Hui-Qun, Peng, Lifei, Tao, Jian-Ping, Zhu, Xing-Quang
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/96142
Acceso en línea:http://hdl.handle.net/10261/96142
Access Level:acceso abierto
Palabra clave:MicroRNA (miRNA)
Ascaris lumbricoides
Ascaris suum
Comparative analysis
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spelling Comparative analysis of microRNA profiles between adult Ascaris lumbricoides and Ascaris suumShao, Chang-ChunXu, Min-JunAlasaad, SamerSong, Hui-QunPeng, LifeiTao, Jian-PingZhu, Xing-QuangMicroRNA (miRNA)Ascaris lumbricoidesAscaris suumComparative analysis[Background] The parasitic nematodes Ascaris lumbricoides and A. suum are of great public health and economic significance, and the two taxa were proposed to represent a single species. miRNAs are known with functions of gene regulations at post-transcriptional level.[Results] We herein compared the miRNA profiles of A. lumbricoides and A. suum female adults by Solexa deep sequencing combined with bioinformatics analysis and stem-loop real-time PCR. Using the A. suum genome as the reference genome, we obtained 171 and 494 miRNA candidates from A. lumbricoides and A. suum, respectively. Among which, 74 miRNAs were shared between the two taxa, 97 and 420 miRNAs were A. lumbricoides and A. suum specific. Target and function prediction revealed a significant set of targets which are related to ovarian message protein, vitellogenin and chondroitin proteoglycan of the two nematodes. Enrichment analysis revealed that the percentages of most predicted functions of the miRNA targets were similar, with some taxon specific or taxon enhanced functions, such as different target numbers, specific functions (NADH dehydrogenase and electron carrier functions), etc.[Conclusions] This study characterized comparatively the miRNAs of adult A. lumbricoides and A. suum, and the findings provide additional evidence that A. lumbricoides and A. suum represent a single species. Due to the fast evolution nature of miRNAs and the different parasitic living conditions of humans and pigs, the phenomenon above might indicate a fast evolution of miRNAs of Ascaris in humans and pigs.This work was supported in part by the International Science & Technology Cooperation Program of China (Grant No. 2013DFA31840), the Science Fund for Creative Research Groups of Gansu Province (Grant No. 1210RJIA006) to XQZ, and the China Postdoctoral Science Foundation (Grant No. 201104363) to MJX.Peer ReviewedBioMed CentralChina Postdoctoral Science FoundationInternational Science & Technology Cooperation (China)Gansu ProvinceConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2014201420142014info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/96142reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1186/1746-6148-10-99Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/961422026-05-22T06:33:51Z
dc.title.none.fl_str_mv Comparative analysis of microRNA profiles between adult Ascaris lumbricoides and Ascaris suum
title Comparative analysis of microRNA profiles between adult Ascaris lumbricoides and Ascaris suum
spellingShingle Comparative analysis of microRNA profiles between adult Ascaris lumbricoides and Ascaris suum
Shao, Chang-Chun
MicroRNA (miRNA)
Ascaris lumbricoides
Ascaris suum
Comparative analysis
title_short Comparative analysis of microRNA profiles between adult Ascaris lumbricoides and Ascaris suum
title_full Comparative analysis of microRNA profiles between adult Ascaris lumbricoides and Ascaris suum
title_fullStr Comparative analysis of microRNA profiles between adult Ascaris lumbricoides and Ascaris suum
title_full_unstemmed Comparative analysis of microRNA profiles between adult Ascaris lumbricoides and Ascaris suum
title_sort Comparative analysis of microRNA profiles between adult Ascaris lumbricoides and Ascaris suum
dc.creator.none.fl_str_mv Shao, Chang-Chun
Xu, Min-Jun
Alasaad, Samer
Song, Hui-Qun
Peng, Lifei
Tao, Jian-Ping
Zhu, Xing-Quang
author Shao, Chang-Chun
author_facet Shao, Chang-Chun
Xu, Min-Jun
Alasaad, Samer
Song, Hui-Qun
Peng, Lifei
Tao, Jian-Ping
Zhu, Xing-Quang
author_role author
author2 Xu, Min-Jun
Alasaad, Samer
Song, Hui-Qun
Peng, Lifei
Tao, Jian-Ping
Zhu, Xing-Quang
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv China Postdoctoral Science Foundation
International Science & Technology Cooperation (China)
Gansu Province
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv MicroRNA (miRNA)
Ascaris lumbricoides
Ascaris suum
Comparative analysis
topic MicroRNA (miRNA)
Ascaris lumbricoides
Ascaris suum
Comparative analysis
description [Background] The parasitic nematodes Ascaris lumbricoides and A. suum are of great public health and economic significance, and the two taxa were proposed to represent a single species. miRNAs are known with functions of gene regulations at post-transcriptional level.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014
2014
2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/96142
url http://hdl.handle.net/10261/96142
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1186/1746-6148-10-99
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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