Mendelian randomization study of sleep traits and risk of colorectal cancer
A potential association of endogenous circadian rhythm disruption with risk of cancer development has been suggested, however, epidemiological evidence for the association of sleep traits with colorectal cancer (CRC) is limited and often contradictory. Here we investigated whether genetically predic...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Recursos: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/221727 |
| Acesso em linha: | https://hdl.handle.net/2445/221727 |
| Access Level: | acceso abierto |
| Palavra-chave: | Càncer colorectal Carcinogènesi Colorectal cancer Carcinogenesis |
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Mendelian randomization study of sleep traits and risk of colorectal cancerDimopoulou, OlympiaFuller, HarriettRichmond, Rebecca C.Bouras, EmmanouilHayes, BryonyDimou, NikiMurphy, NeilBrenner, HermannGsur, AndreaLe Marchand, LoïcMoreno Aguado, VíctorPai, Rish K.Phipps, Amanda I.Um, Caroline Y.Duijnhoven, Franzel J. B. vanVodicka, PavelMartin, Richard M.Platz, Elizabeth A.Gunter, Marc J.Peters, UlrikeLewis, Sarah J.Cao, YinTsilidis, Konstantinos K.Càncer colorectalCarcinogènesiColorectal cancerCarcinogenesisA potential association of endogenous circadian rhythm disruption with risk of cancer development has been suggested, however, epidemiological evidence for the association of sleep traits with colorectal cancer (CRC) is limited and often contradictory. Here we investigated whether genetically predicted chronotype, insomnia and sleep duration are associated with CRC risk in males, females and overall and according to CRC anatomical subsites using Mendelian randomization (MR). The two-sample inverse variance weighted (IVW) method was applied using summary-level data in up to 58,221 CRC cases and 67,694 controls and genome-wide association data of genetic variants for self-reported sleep traits. Secondary analyses using alternative instruments and sensitivity analyses assessing potential violations of MR assumptions were conducted. Genetically predicted morning preference was associated with 13% lower risk of CRC in men (ORIVW = 0.87, 95% CI = 0.78, 0.97, P = 0.01), but not in women or in both sexes combined. Tau his association remained consistent in some, but not all, sensitivity analyses and was very similar for colon and rectal cancer. There was no evidence of an association for any other sleep trait. Overall, this study provides little to no evidence of an association between genetically predicted sleep traits and CRC risk.Springer Science and Business Media LLC2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/221727Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1038/s41598-024-83693-wScientific Reports, 2025, vol. 15https://doi.org/10.1038/s41598-024-83693-wcc-by (c) Dimopoulou et al., 2024http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2217272026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Mendelian randomization study of sleep traits and risk of colorectal cancer |
| title |
Mendelian randomization study of sleep traits and risk of colorectal cancer |
| spellingShingle |
Mendelian randomization study of sleep traits and risk of colorectal cancer Dimopoulou, Olympia Càncer colorectal Carcinogènesi Colorectal cancer Carcinogenesis |
| title_short |
Mendelian randomization study of sleep traits and risk of colorectal cancer |
| title_full |
Mendelian randomization study of sleep traits and risk of colorectal cancer |
| title_fullStr |
Mendelian randomization study of sleep traits and risk of colorectal cancer |
| title_full_unstemmed |
Mendelian randomization study of sleep traits and risk of colorectal cancer |
| title_sort |
Mendelian randomization study of sleep traits and risk of colorectal cancer |
| dc.creator.none.fl_str_mv |
Dimopoulou, Olympia Fuller, Harriett Richmond, Rebecca C. Bouras, Emmanouil Hayes, Bryony Dimou, Niki Murphy, Neil Brenner, Hermann Gsur, Andrea Le Marchand, Loïc Moreno Aguado, Víctor Pai, Rish K. Phipps, Amanda I. Um, Caroline Y. Duijnhoven, Franzel J. B. van Vodicka, Pavel Martin, Richard M. Platz, Elizabeth A. Gunter, Marc J. Peters, Ulrike Lewis, Sarah J. Cao, Yin Tsilidis, Konstantinos K. |
| author |
Dimopoulou, Olympia |
| author_facet |
Dimopoulou, Olympia Fuller, Harriett Richmond, Rebecca C. Bouras, Emmanouil Hayes, Bryony Dimou, Niki Murphy, Neil Brenner, Hermann Gsur, Andrea Le Marchand, Loïc Moreno Aguado, Víctor Pai, Rish K. Phipps, Amanda I. Um, Caroline Y. Duijnhoven, Franzel J. B. van Vodicka, Pavel Martin, Richard M. Platz, Elizabeth A. Gunter, Marc J. Peters, Ulrike Lewis, Sarah J. Cao, Yin Tsilidis, Konstantinos K. |
| author_role |
author |
| author2 |
Fuller, Harriett Richmond, Rebecca C. Bouras, Emmanouil Hayes, Bryony Dimou, Niki Murphy, Neil Brenner, Hermann Gsur, Andrea Le Marchand, Loïc Moreno Aguado, Víctor Pai, Rish K. Phipps, Amanda I. Um, Caroline Y. Duijnhoven, Franzel J. B. van Vodicka, Pavel Martin, Richard M. Platz, Elizabeth A. Gunter, Marc J. Peters, Ulrike Lewis, Sarah J. Cao, Yin Tsilidis, Konstantinos K. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Càncer colorectal Carcinogènesi Colorectal cancer Carcinogenesis |
| topic |
Càncer colorectal Carcinogènesi Colorectal cancer Carcinogenesis |
| description |
A potential association of endogenous circadian rhythm disruption with risk of cancer development has been suggested, however, epidemiological evidence for the association of sleep traits with colorectal cancer (CRC) is limited and often contradictory. Here we investigated whether genetically predicted chronotype, insomnia and sleep duration are associated with CRC risk in males, females and overall and according to CRC anatomical subsites using Mendelian randomization (MR). The two-sample inverse variance weighted (IVW) method was applied using summary-level data in up to 58,221 CRC cases and 67,694 controls and genome-wide association data of genetic variants for self-reported sleep traits. Secondary analyses using alternative instruments and sensitivity analyses assessing potential violations of MR assumptions were conducted. Genetically predicted morning preference was associated with 13% lower risk of CRC in men (ORIVW = 0.87, 95% CI = 0.78, 0.97, P = 0.01), but not in women or in both sexes combined. Tau his association remained consistent in some, but not all, sensitivity analyses and was very similar for colon and rectal cancer. There was no evidence of an association for any other sleep trait. Overall, this study provides little to no evidence of an association between genetically predicted sleep traits and CRC risk. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/221727 |
| url |
https://hdl.handle.net/2445/221727 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.1038/s41598-024-83693-w Scientific Reports, 2025, vol. 15 https://doi.org/10.1038/s41598-024-83693-w |
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cc-by (c) Dimopoulou et al., 2024 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess |
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cc-by (c) Dimopoulou et al., 2024 http://creativecommons.org/licenses/by/3.0/es/ |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Springer Science and Business Media LLC |
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Springer Science and Business Media LLC |
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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
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Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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