Comparison of quality of life after stereotactic body radiotherapy and surgery for early-stage prostate cancer
BACKGROUND: As the long-term efficacy of stereotactic body radiation therapy (SBRT) becomes established and other prostate cancer treatment approaches are refined and improved, examination of quality of life (QOL) following prostate cancer treatment is critical in driving both patient and clinical t...
| Autores: | , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2012 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/25421 |
| Acceso en línea: | http://hdl.handle.net/10230/25421 http://dx.doi.org/10.1186/1748-717X-7-194 |
| Access Level: | acceso abierto |
| Palabra clave: | Pròstata -- Càncer -- Tractament Impotència sexual Prostate cancer Prostatectomy Quality of life Stereotactic body radiotherapy |
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Comparison of quality of life after stereotactic body radiotherapy and surgery for early-stage prostate cancerKatz, AlanFerrer Forés, Maria MontserratAlonso Caballero, JordiBecerra Bachino, Virginia, 1975-Cunillera, OriolGarin Boronat, Olatz, 1979-Pardo Cladellas, YolandaPont Acuña, ÀngelsMulticentric Spanish Group of Clinically Localized Prostate CancerPròstata -- Càncer -- TractamentImpotència sexualProstate cancerProstatectomyQuality of lifeStereotactic body radiotherapyBACKGROUND: As the long-term efficacy of stereotactic body radiation therapy (SBRT) becomes established and other prostate cancer treatment approaches are refined and improved, examination of quality of life (QOL) following prostate cancer treatment is critical in driving both patient and clinical treatment decisions. We present the first study to compare QOL after SBRT and radical prostatectomy, with QOL assessed at approximately the same times pre- and post-treatment and using the same validated QOL instrument. METHODS: Patients with clinically localized prostate cancer were treated with either radical prostatectomy (n = 123 Spanish patients) or SBRT (n = 216 American patients). QOL was assessed using the Expanded Prostate Cancer Index Composite (EPIC) grouped into urinary, sexual, and bowel domains. For comparison purposes, SBRT EPIC data at baseline, 3 weeks, 5, 11, 24, and 36 months were compared to surgery data at baseline, 1, 6, 12, 24, and 36 months. Differences in patient characteristics between the two groups were assessed using Chi-squared tests for categorical variables and t-tests for continuous variables. Generalized estimating equation (GEE) models were constructed for each EPIC scale to account for correlation among repeated measures and used to assess the effect of treatment on QOL. RESULTS: The largest differences in QOL occurred in the first 1-6 months after treatment, with larger declines following surgery in urinary and sexual QOL as compared to SBRT, and a larger decline in bowel QOL following SBRT as compared to surgery. Long-term urinary and sexual QOL declines remained clinically significantly lower for surgery patients but not for SBRT patients. CONCLUSIONS: Overall, these results may have implications for patient and physician clinical decision making which are often influenced by QOL. These differences in sexual, urinary and bowel QOL should be closely considered in selecting the right treatment, especially in evaluating the value of non-invasive treatments, such as SBRT.BioMed Central201520152012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/25421http://dx.doi.org/10.1186/1748-717X-7-194reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésRadiation oncology. 2012. 7: 194© Katz et al. Creative Commons Attribution License http://creativecommons.org/licenses/by/2.0/http://creativecommons.org/licenses/by/2.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/254212026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Comparison of quality of life after stereotactic body radiotherapy and surgery for early-stage prostate cancer |
| title |
Comparison of quality of life after stereotactic body radiotherapy and surgery for early-stage prostate cancer |
| spellingShingle |
Comparison of quality of life after stereotactic body radiotherapy and surgery for early-stage prostate cancer Katz, Alan Pròstata -- Càncer -- Tractament Impotència sexual Prostate cancer Prostatectomy Quality of life Stereotactic body radiotherapy |
| title_short |
Comparison of quality of life after stereotactic body radiotherapy and surgery for early-stage prostate cancer |
| title_full |
Comparison of quality of life after stereotactic body radiotherapy and surgery for early-stage prostate cancer |
| title_fullStr |
Comparison of quality of life after stereotactic body radiotherapy and surgery for early-stage prostate cancer |
| title_full_unstemmed |
Comparison of quality of life after stereotactic body radiotherapy and surgery for early-stage prostate cancer |
| title_sort |
Comparison of quality of life after stereotactic body radiotherapy and surgery for early-stage prostate cancer |
| dc.creator.none.fl_str_mv |
Katz, Alan Ferrer Forés, Maria Montserrat Alonso Caballero, Jordi Becerra Bachino, Virginia, 1975- Cunillera, Oriol Garin Boronat, Olatz, 1979- Pardo Cladellas, Yolanda Pont Acuña, Àngels Multicentric Spanish Group of Clinically Localized Prostate Cancer |
| author |
Katz, Alan |
| author_facet |
Katz, Alan Ferrer Forés, Maria Montserrat Alonso Caballero, Jordi Becerra Bachino, Virginia, 1975- Cunillera, Oriol Garin Boronat, Olatz, 1979- Pardo Cladellas, Yolanda Pont Acuña, Àngels Multicentric Spanish Group of Clinically Localized Prostate Cancer |
| author_role |
author |
| author2 |
Ferrer Forés, Maria Montserrat Alonso Caballero, Jordi Becerra Bachino, Virginia, 1975- Cunillera, Oriol Garin Boronat, Olatz, 1979- Pardo Cladellas, Yolanda Pont Acuña, Àngels Multicentric Spanish Group of Clinically Localized Prostate Cancer |
| author2_role |
author author author author author author author author |
| dc.subject.none.fl_str_mv |
Pròstata -- Càncer -- Tractament Impotència sexual Prostate cancer Prostatectomy Quality of life Stereotactic body radiotherapy |
| topic |
Pròstata -- Càncer -- Tractament Impotència sexual Prostate cancer Prostatectomy Quality of life Stereotactic body radiotherapy |
| description |
BACKGROUND: As the long-term efficacy of stereotactic body radiation therapy (SBRT) becomes established and other prostate cancer treatment approaches are refined and improved, examination of quality of life (QOL) following prostate cancer treatment is critical in driving both patient and clinical treatment decisions. We present the first study to compare QOL after SBRT and radical prostatectomy, with QOL assessed at approximately the same times pre- and post-treatment and using the same validated QOL instrument. METHODS: Patients with clinically localized prostate cancer were treated with either radical prostatectomy (n = 123 Spanish patients) or SBRT (n = 216 American patients). QOL was assessed using the Expanded Prostate Cancer Index Composite (EPIC) grouped into urinary, sexual, and bowel domains. For comparison purposes, SBRT EPIC data at baseline, 3 weeks, 5, 11, 24, and 36 months were compared to surgery data at baseline, 1, 6, 12, 24, and 36 months. Differences in patient characteristics between the two groups were assessed using Chi-squared tests for categorical variables and t-tests for continuous variables. Generalized estimating equation (GEE) models were constructed for each EPIC scale to account for correlation among repeated measures and used to assess the effect of treatment on QOL. RESULTS: The largest differences in QOL occurred in the first 1-6 months after treatment, with larger declines following surgery in urinary and sexual QOL as compared to SBRT, and a larger decline in bowel QOL following SBRT as compared to surgery. Long-term urinary and sexual QOL declines remained clinically significantly lower for surgery patients but not for SBRT patients. CONCLUSIONS: Overall, these results may have implications for patient and physician clinical decision making which are often influenced by QOL. These differences in sexual, urinary and bowel QOL should be closely considered in selecting the right treatment, especially in evaluating the value of non-invasive treatments, such as SBRT. |
| publishDate |
2012 |
| dc.date.none.fl_str_mv |
2012 2015 2015 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10230/25421 http://dx.doi.org/10.1186/1748-717X-7-194 |
| url |
http://hdl.handle.net/10230/25421 http://dx.doi.org/10.1186/1748-717X-7-194 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Radiation oncology. 2012. 7: 194 |
| dc.rights.none.fl_str_mv |
© Katz et al. Creative Commons Attribution License http://creativecommons.org/licenses/by/2.0/ http://creativecommons.org/licenses/by/2.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
© Katz et al. Creative Commons Attribution License http://creativecommons.org/licenses/by/2.0/ http://creativecommons.org/licenses/by/2.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
BioMed Central |
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BioMed Central |
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reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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