Damage in a large systemic lupus erythematosus cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER) with emphasis on the cardiovascular system: a longitudinal analysis
Objective: To assess organ damage, with emphasis on the cardiovascular system, over the different stages of the disease in a large SLE cohort. Methods: Multicentre, longitudinal study of a cohort of 4219 patients with SLE enrolled in the Spanish Society of Rheumatology Lupus Registry. Organ damage w...
| Autores: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Recursos: | Universidad de Cantabria (UC) |
| Repositorio: | UCrea Repositorio Abierto de la Universidad de Cantabria |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unican.es:10902/34514 |
| Acesso em linha: | https://hdl.handle.net/10902/34514 |
| Access Level: | acceso abierto |
| Palavra-chave: | Autoimmune diseases Cardiovascular diseases Lupus Erythematosus Systemic |
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ES_1b4e042f26caced76a9dff677a31de66 |
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oai:repositorio.unican.es:10902/34514 |
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ES |
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España |
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| dc.title.none.fl_str_mv |
Damage in a large systemic lupus erythematosus cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER) with emphasis on the cardiovascular system: a longitudinal analysis |
| title |
Damage in a large systemic lupus erythematosus cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER) with emphasis on the cardiovascular system: a longitudinal analysis |
| spellingShingle |
Damage in a large systemic lupus erythematosus cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER) with emphasis on the cardiovascular system: a longitudinal analysis Altabás-González, Irene Autoimmune diseases Cardiovascular diseases Lupus Erythematosus Systemic |
| title_short |
Damage in a large systemic lupus erythematosus cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER) with emphasis on the cardiovascular system: a longitudinal analysis |
| title_full |
Damage in a large systemic lupus erythematosus cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER) with emphasis on the cardiovascular system: a longitudinal analysis |
| title_fullStr |
Damage in a large systemic lupus erythematosus cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER) with emphasis on the cardiovascular system: a longitudinal analysis |
| title_full_unstemmed |
Damage in a large systemic lupus erythematosus cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER) with emphasis on the cardiovascular system: a longitudinal analysis |
| title_sort |
Damage in a large systemic lupus erythematosus cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER) with emphasis on the cardiovascular system: a longitudinal analysis |
| dc.creator.none.fl_str_mv |
Altabás-González, Irene Rua-Figueroa, Iñigo Mouriño, Coral Roberts, Karen Jiménez, Norman Martínez-Barrio, Julia Galindo, María Calvo Alén, Jaime Del Campo Pérez, Víctor Uriarte Itzazelaia, Esther Tomero, Eva Freire-González, Mercedes Martínez Taboada, Víctor Manuel Salgado, Eva Vela, Paloma Fernández-Nebro, Antonio Olivé, Alejandro Narváez, Javier Menor-Almagro, Raúl Santo Soler, Gregorio |
| author |
Altabás-González, Irene |
| author_facet |
Altabás-González, Irene Rua-Figueroa, Iñigo Mouriño, Coral Roberts, Karen Jiménez, Norman Martínez-Barrio, Julia Galindo, María Calvo Alén, Jaime Del Campo Pérez, Víctor Uriarte Itzazelaia, Esther Tomero, Eva Freire-González, Mercedes Martínez Taboada, Víctor Manuel Salgado, Eva Vela, Paloma Fernández-Nebro, Antonio Olivé, Alejandro Narváez, Javier Menor-Almagro, Raúl Santo Soler, Gregorio |
| author_role |
author |
| author2 |
Rua-Figueroa, Iñigo Mouriño, Coral Roberts, Karen Jiménez, Norman Martínez-Barrio, Julia Galindo, María Calvo Alén, Jaime Del Campo Pérez, Víctor Uriarte Itzazelaia, Esther Tomero, Eva Freire-González, Mercedes Martínez Taboada, Víctor Manuel Salgado, Eva Vela, Paloma Fernández-Nebro, Antonio Olivé, Alejandro Narváez, Javier Menor-Almagro, Raúl Santo Soler, Gregorio |
| author2_role |
author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidad de Cantabria |
| dc.subject.none.fl_str_mv |
Autoimmune diseases Cardiovascular diseases Lupus Erythematosus Systemic |
| topic |
Autoimmune diseases Cardiovascular diseases Lupus Erythematosus Systemic |
| description |
Objective: To assess organ damage, with emphasis on the cardiovascular system, over the different stages of the disease in a large SLE cohort. Methods: Multicentre, longitudinal study of a cohort of 4219 patients with SLE enrolled in the Spanish Society of Rheumatology Lupus Registry. Organ damage was ascertained using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI). We longitudinally analysed SDI (globally and for each domain) over time only in the 1274 patients whose dates of damage events had been recorded. Results: During the first year after diagnosis of SLE, 20% of the 1274 patients presented with new damage manifestations. At years 2 and 3, new damage was recorded in 11% and 9% of patients. The annual percentage of patients with new damage after year 5 decreased to 5%. In the first year with the disease, most damage was accumulated in the musculoskeletal, neuropsychiatric and renal systems; in later stages, most damage was in the musculoskeletal, ocular and cardiovascular systems. Considering 'cerebrovascular accident' and 'claudication for 6 months' as cardiovascular items, the cardiovascular system was the second most affected system during the early stages of SLE, with 19% of the patients who presented with damage affected at first year after diagnosis. During the late stages, 20-25% of the patients presenting with new damage did so in this modified cardiovascular domain of the SDI. Conclusions: New damage occurs mainly during the first year following diagnosis of SLE. Cardiovascular damage is relevant in both the early and the late stages of the disease. Strategies to prevent cardiovascular damage should be implemented early after diagnosis of SLE. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2024-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 NA http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10902/34514 |
| url |
https://hdl.handle.net/10902/34514 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
BMJ Publishing Group |
| publisher.none.fl_str_mv |
BMJ Publishing Group |
| dc.source.none.fl_str_mv |
Lupus Science and Medicine, 2024, 11, e001064 reponame:UCrea Repositorio Abierto de la Universidad de Cantabria instname:Universidad de Cantabria (UC) |
| instname_str |
Universidad de Cantabria (UC) |
| reponame_str |
UCrea Repositorio Abierto de la Universidad de Cantabria |
| collection |
UCrea Repositorio Abierto de la Universidad de Cantabria |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869404157276848128 |
| spelling |
Damage in a large systemic lupus erythematosus cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER) with emphasis on the cardiovascular system: a longitudinal analysisAltabás-González, IreneRua-Figueroa, IñigoMouriño, CoralRoberts, KarenJiménez, NormanMartínez-Barrio, JuliaGalindo, MaríaCalvo Alén, JaimeDel Campo Pérez, VíctorUriarte Itzazelaia, EstherTomero, EvaFreire-González, MercedesMartínez Taboada, Víctor ManuelSalgado, EvaVela, PalomaFernández-Nebro, AntonioOlivé, AlejandroNarváez, JavierMenor-Almagro, RaúlSanto Soler, GregorioAutoimmune diseasesCardiovascular diseasesLupus ErythematosusSystemicObjective: To assess organ damage, with emphasis on the cardiovascular system, over the different stages of the disease in a large SLE cohort. Methods: Multicentre, longitudinal study of a cohort of 4219 patients with SLE enrolled in the Spanish Society of Rheumatology Lupus Registry. Organ damage was ascertained using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI). We longitudinally analysed SDI (globally and for each domain) over time only in the 1274 patients whose dates of damage events had been recorded. Results: During the first year after diagnosis of SLE, 20% of the 1274 patients presented with new damage manifestations. At years 2 and 3, new damage was recorded in 11% and 9% of patients. The annual percentage of patients with new damage after year 5 decreased to 5%. In the first year with the disease, most damage was accumulated in the musculoskeletal, neuropsychiatric and renal systems; in later stages, most damage was in the musculoskeletal, ocular and cardiovascular systems. Considering 'cerebrovascular accident' and 'claudication for 6 months' as cardiovascular items, the cardiovascular system was the second most affected system during the early stages of SLE, with 19% of the patients who presented with damage affected at first year after diagnosis. During the late stages, 20-25% of the patients presenting with new damage did so in this modified cardiovascular domain of the SDI. Conclusions: New damage occurs mainly during the first year following diagnosis of SLE. Cardiovascular damage is relevant in both the early and the late stages of the disease. Strategies to prevent cardiovascular damage should be implemented early after diagnosis of SLE.Funding: The RELESSER was supported by the Spanish Society of Rheumatology. Grants from GlaxoSmithKline, Roche, Union Chimique Belge and Novartis contributed to the support of the cross-sectional stage of the registry. No specific funding was received from any funding bodies in the public, commercial or not-forprofit sectors to carry out the work described in this manuscript. IA-G is supported by ACI FER (21/CONV/02/1266). JMP-R is supported by the FIS/ISCIII-Fondo Europeo de Desarrollo regional (FEDER) (grant number PI11/02857). Acknowledgements: We thank the Spanish Foundation of Rheumatology (grant FERBT2022) for providing editorial assistance during the preparation of the manuscript. We thank Juan Manuel Barrio (Research Unit of the Spanish Society of Rheumatology) who helped establish the database. We also would like to thank all the investigators who participated in this study: Inmaculada de la Torre Ortega, Luis Carreño Pérez, Patricia Carreira Delgado, Esther Rodríguez-Almaraz, Juan Antonio Martínez López, Olga Sánchez Pernaute, Txaro Garcia de Vicuña Pinedo, Marta Valero Expósito, Paloma García de la Peña, Silvia Rodríguez Rubio, Jorge J González Martín, Ana Pérez Gómez, Cristina Bohórquez, Atusa Morasat Hajkhan, Ana I Turrión Nieves, Jose Luis Andréu Sánchez, Aline Lucice Boteanu, M Luz Gamir Gamir and Patricia Richi Alberti (Madrid); José Carlos Rosas-Gómez de Salazar, Esteban Salas Heredia, Carlos Santos Ramírez and José M Senabre Gallego (Villajoyosa Alicante); José Antonio Bernal (Alicante); Inmaculada Ros Vilamajo, Antonio Juan Mas and Claudia Murillo (Palma de Mallorca); Emma García Melchor (Badalona); María García Manrique, Carlos Galisteo Lencastre and Mireia Moreno Martınez-Losa (Sabadell); Ricardo Blanco, Miguel A González-Gay Mantecón, Inés Pérez Martín and M del Carmen Bejerano (Santander); Ignacio Villa Blanco, Begoña Moreira, Elena Aurrecoechea and Teresa Ruiz Jimeno (Torrelavega); Angeles Aguirre Zamorano (Córdoba); César Magro (Granada); M Angeles Acosta Mérida (Las Palmas de Gran Canaria); César A Egues Dubuc and Jorge Cancio Fanlo (San Sebastián); Carlos Vitovi and Alejandra Lopez Robles (Leon); Rafael Benito Melero-González (Orense); M Victoria Irigoyen Oyarzabal, M Angeles Belmonte López and Carmen M Romero Barco (Malaga); María Rosario Oliva (Murcia); Claudia Stoye and María Concepción Fito-Manteca (Pamplona); Inigo Hernández Rodríguez and Bruno de Aspe de la Iglesia (Vigo); Ruth López González (Salamanca); Federico Navarro Sarabia, Francisco J Toyos Sáenz de Miera, Julia Uceda Montañés, Raquel Hernández Sánchez and Rosalía Martínez Pérez (Sevilla); Beatriz Rodríguez Lozano (Tenerife); Eduardo Ucar Angulo, Olaia Fernández Berrizbeitia and Luis López Domínguez (Bilbao); Isabel de La Morena Barrio and Elia Valls (Valencia); Javier Manero Ruiz (Zaragoza); Sergio Machín and Javier Novoa (Gran Canaria).BMJ Publishing GroupUniversidad de Cantabria20242024-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttps://hdl.handle.net/10902/34514Lupus Science and Medicine, 2024, 11, e001064reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/345142026-06-02T12:39:31Z |
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15,811543 |