A straightforward preparation of aminoglycoside-dinucleotide and -diPNA conjugates via click ligation assisted by microwaves
An alternative and straightforward method to prepare aminoglycoside-dinucleotide and -diPNA conjugates is reported, which is based on copper-catalyzed Huisgen azide-alkyne cycloaddition ("click chemistry" ligation) assisted by microwave irradiation. This method permitted conjugations to be...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2010 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/71780 |
| Acceso en línea: | http://hdl.handle.net/10230/71780 http://dx.doi.org/10.1002/ejoc.201000182 |
| Access Level: | acceso abierto |
| Palabra clave: | Aminoglycoside Nucleic acids Conjugate Cycloaddition Microwaves |
| Sumario: | An alternative and straightforward method to prepare aminoglycoside-dinucleotide and -diPNA conjugates is reported, which is based on copper-catalyzed Huisgen azide-alkyne cycloaddition ("click chemistry" ligation) assisted by microwave irradiation. This method permitted conjugations to be performed in aqueous solution, in very short times and with readily prepared precursors. |
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