A comparison of acute pharmacological effects of methylone and MDMA administration in humans and oral fluid concentrations as biomarkers of exposure

Considered the β-keto analogue of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy), 3,4-Methylenedioxymethcathinone (methylone) is a synthetic cathinone. Over the years, methylone has been used as a substitute for conventional psychostimulants, such as MDMA. To date, little is known about the human...

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Autores: Poyatos, Lourdes, Papaseit Fontanet, Esther, Olesti Muñoz, Eulàlia, 1991-, Pérez Mañá, Clara, Ventura, Mireia, Carbón Mallol, Xoán, Grifell Guardia, Marc, Fonseca Casals, Francina, 1972-, Torrens, Marta, Torre Fornell, Rafael de la, Farré Albaladejo, Magí
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/48674
Acceso en línea:http://hdl.handle.net/10230/48674
http://dx.doi.org/10.3390/biology10080788
Access Level:acceso abierto
Palabra clave:MDMA (3,4-methylenedioxymethamphetamine)
Bath salts
Methylone (3,4-methylenedioxymethcathinone)
New psychoactive substances (NPS)
Psychostimulants
Synthetic cathinones
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spelling A comparison of acute pharmacological effects of methylone and MDMA administration in humans and oral fluid concentrations as biomarkers of exposurePoyatos, LourdesPapaseit Fontanet, EstherOlesti Muñoz, Eulàlia, 1991-Pérez Mañá, ClaraVentura, MireiaCarbón Mallol, XoánGrifell Guardia, MarcFonseca Casals, Francina, 1972-Torrens, MartaTorre Fornell, Rafael de laFarré Albaladejo, MagíMDMA (3,4-methylenedioxymethamphetamine)Bath saltsMethylone (3,4-methylenedioxymethcathinone)New psychoactive substances (NPS)PsychostimulantsSynthetic cathinonesConsidered the β-keto analogue of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy), 3,4-Methylenedioxymethcathinone (methylone) is a synthetic cathinone. Over the years, methylone has been used as a substitute for conventional psychostimulants, such as MDMA. To date, little is known about the human pharmacology of methylone; the only available information has been provided by surveys or published intoxication reports. In the present observational-naturalistic study, we evaluate the acute subjective and physiological effects of methylone after oral self-administration in comparison to MDMA in healthy poly-drug users. Fourteen participants (10 males, 4 females) selected their single oral doses of methylone from 100 to 300 mg (n = 8, mean dose 187.5 mg) or MDMA from 75 to 100 mg (n = 6, mean dose 87.5 mg) based on their experience. Study variables were assessed at 0, 1, 2, and 4 h (h) and included vital signs (non-invasive blood pressure, heart rate, cutaneous temperature) and subjective effects using visual analogue scales (VAS), the 49-item Addiction Research Centre Inventory (ARCI) short form, and the Evaluation of the Subjective Effects of Substances with Abuse Potential (VESSPA-SSE) questionnaire. Additionally, oral fluid concentrations of methylone and MDMA were determined. Acute pharmacological effects produced by methylone followed the prototypical psychostimulant and empathogenic profile associated with MDMA, although they were less intense. Methylone concentrations in oral fluid can be considered a useful biomarker to detect acute exposure in oral fluid. Oral fluid concentrations of MDMA and methylone peaked at 2 h and concentrations of MDMA were in the range of those previously described in controlled studies. Our results demonstrate that the potential abuse liability of methylone is similar to that of MDMA in recreational subjects.MDPI202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/48674http://dx.doi.org/10.3390/biology10080788reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésBiology (Basel). 2021;10(8):788© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/486742026-06-12T07:21:37Z
dc.title.none.fl_str_mv A comparison of acute pharmacological effects of methylone and MDMA administration in humans and oral fluid concentrations as biomarkers of exposure
title A comparison of acute pharmacological effects of methylone and MDMA administration in humans and oral fluid concentrations as biomarkers of exposure
spellingShingle A comparison of acute pharmacological effects of methylone and MDMA administration in humans and oral fluid concentrations as biomarkers of exposure
Poyatos, Lourdes
MDMA (3,4-methylenedioxymethamphetamine)
Bath salts
Methylone (3,4-methylenedioxymethcathinone)
New psychoactive substances (NPS)
Psychostimulants
Synthetic cathinones
title_short A comparison of acute pharmacological effects of methylone and MDMA administration in humans and oral fluid concentrations as biomarkers of exposure
title_full A comparison of acute pharmacological effects of methylone and MDMA administration in humans and oral fluid concentrations as biomarkers of exposure
title_fullStr A comparison of acute pharmacological effects of methylone and MDMA administration in humans and oral fluid concentrations as biomarkers of exposure
title_full_unstemmed A comparison of acute pharmacological effects of methylone and MDMA administration in humans and oral fluid concentrations as biomarkers of exposure
title_sort A comparison of acute pharmacological effects of methylone and MDMA administration in humans and oral fluid concentrations as biomarkers of exposure
dc.creator.none.fl_str_mv Poyatos, Lourdes
Papaseit Fontanet, Esther
Olesti Muñoz, Eulàlia, 1991-
Pérez Mañá, Clara
Ventura, Mireia
Carbón Mallol, Xoán
Grifell Guardia, Marc
Fonseca Casals, Francina, 1972-
Torrens, Marta
Torre Fornell, Rafael de la
Farré Albaladejo, Magí
author Poyatos, Lourdes
author_facet Poyatos, Lourdes
Papaseit Fontanet, Esther
Olesti Muñoz, Eulàlia, 1991-
Pérez Mañá, Clara
Ventura, Mireia
Carbón Mallol, Xoán
Grifell Guardia, Marc
Fonseca Casals, Francina, 1972-
Torrens, Marta
Torre Fornell, Rafael de la
Farré Albaladejo, Magí
author_role author
author2 Papaseit Fontanet, Esther
Olesti Muñoz, Eulàlia, 1991-
Pérez Mañá, Clara
Ventura, Mireia
Carbón Mallol, Xoán
Grifell Guardia, Marc
Fonseca Casals, Francina, 1972-
Torrens, Marta
Torre Fornell, Rafael de la
Farré Albaladejo, Magí
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv MDMA (3,4-methylenedioxymethamphetamine)
Bath salts
Methylone (3,4-methylenedioxymethcathinone)
New psychoactive substances (NPS)
Psychostimulants
Synthetic cathinones
topic MDMA (3,4-methylenedioxymethamphetamine)
Bath salts
Methylone (3,4-methylenedioxymethcathinone)
New psychoactive substances (NPS)
Psychostimulants
Synthetic cathinones
description Considered the β-keto analogue of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy), 3,4-Methylenedioxymethcathinone (methylone) is a synthetic cathinone. Over the years, methylone has been used as a substitute for conventional psychostimulants, such as MDMA. To date, little is known about the human pharmacology of methylone; the only available information has been provided by surveys or published intoxication reports. In the present observational-naturalistic study, we evaluate the acute subjective and physiological effects of methylone after oral self-administration in comparison to MDMA in healthy poly-drug users. Fourteen participants (10 males, 4 females) selected their single oral doses of methylone from 100 to 300 mg (n = 8, mean dose 187.5 mg) or MDMA from 75 to 100 mg (n = 6, mean dose 87.5 mg) based on their experience. Study variables were assessed at 0, 1, 2, and 4 h (h) and included vital signs (non-invasive blood pressure, heart rate, cutaneous temperature) and subjective effects using visual analogue scales (VAS), the 49-item Addiction Research Centre Inventory (ARCI) short form, and the Evaluation of the Subjective Effects of Substances with Abuse Potential (VESSPA-SSE) questionnaire. Additionally, oral fluid concentrations of methylone and MDMA were determined. Acute pharmacological effects produced by methylone followed the prototypical psychostimulant and empathogenic profile associated with MDMA, although they were less intense. Methylone concentrations in oral fluid can be considered a useful biomarker to detect acute exposure in oral fluid. Oral fluid concentrations of MDMA and methylone peaked at 2 h and concentrations of MDMA were in the range of those previously described in controlled studies. Our results demonstrate that the potential abuse liability of methylone is similar to that of MDMA in recreational subjects.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/48674
http://dx.doi.org/10.3390/biology10080788
url http://hdl.handle.net/10230/48674
http://dx.doi.org/10.3390/biology10080788
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Biology (Basel). 2021;10(8):788
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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