Determining the persistence of Mycobacterium bovis bacille Calmette-Guerin Danish in select tissues of orally vaccinated feral swine (Sus scrofa ssp.)

Mycobacterium bovis bacille Calmette–Guerin (BCG) is being considered for vaccination of feral swine (Sus scrofa ssp.). Since BCG is a live bacterium, evaluation of its safety and persistence in tissues is important. Fifteen feral swine received approximately 4.5 × 106 colony forming units of BCG Da...

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Detalles Bibliográficos
Autores: Nol, Pauline, Robbe-Austerman, Suelee, Rhyan, Jack C., McCollum, Matt P., Triantis, Joni M., Beltrán-Beck, Beatriz, Salman, Mo D.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/173952
Acceso en línea:http://hdl.handle.net/10261/173952
Access Level:acceso abierto
Palabra clave:Tissue persistence
Feral swine
BCG
Bovine tuberculosis
Vaccine
Mycobacterium bovis
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spelling Determining the persistence of Mycobacterium bovis bacille Calmette-Guerin Danish in select tissues of orally vaccinated feral swine (Sus scrofa ssp.)Nol, PaulineRobbe-Austerman, SueleeRhyan, Jack C.McCollum, Matt P.Triantis, Joni M.Beltrán-Beck, BeatrizSalman, Mo D.Tissue persistenceFeral swineBCGBovine tuberculosisVaccineMycobacterium bovisMycobacterium bovis bacille Calmette–Guerin (BCG) is being considered for vaccination of feral swine (Sus scrofa ssp.). Since BCG is a live bacterium, evaluation of its safety and persistence in tissues is important. Fifteen feral swine received approximately 4.5 × 106 colony forming units of BCG Danish via oral bait. Four animals received bait without BCG. At 1, 3, 6, and 9 months post-vaccination, four vaccinates were euthanized. Non-vaccinates were euthanized at 9 months. Clinical signs were not noted in vaccinated pigs at any time. Tissues from all 20 pigs were culture-negative for mycobacteria. Based on our data, BCG is safe and appears not to persist in feral swine tissues after one month post-oral vaccination. However, further work must be performed at higher doses, and on a larger number of animals representing the target population, and further evaluation of persistence in tissues within the first month post-vaccination is needed.This work was funded by USDA APHIS Veterinary Services and SaBio-IREC (Cuenta con Personal Perteneciente—Universidad de Castilla la Mancha—La Junta de Comunidades de Castilla La Mancha) is a contribution to Plan Nacional I + D + i research grant AGL2011-30,041 from MINECO and the EU FP7 grant WildTBVac.Peer ReviewedElsevierEuropean CommissionDepartment of Agriculture (US)Universidad de Castilla La ManchaMinisterio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2019201920162019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/173952reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1016/j.rvsc.2015.11.007Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1739522026-05-22T06:33:51Z
dc.title.none.fl_str_mv Determining the persistence of Mycobacterium bovis bacille Calmette-Guerin Danish in select tissues of orally vaccinated feral swine (Sus scrofa ssp.)
title Determining the persistence of Mycobacterium bovis bacille Calmette-Guerin Danish in select tissues of orally vaccinated feral swine (Sus scrofa ssp.)
spellingShingle Determining the persistence of Mycobacterium bovis bacille Calmette-Guerin Danish in select tissues of orally vaccinated feral swine (Sus scrofa ssp.)
Nol, Pauline
Tissue persistence
Feral swine
BCG
Bovine tuberculosis
Vaccine
Mycobacterium bovis
title_short Determining the persistence of Mycobacterium bovis bacille Calmette-Guerin Danish in select tissues of orally vaccinated feral swine (Sus scrofa ssp.)
title_full Determining the persistence of Mycobacterium bovis bacille Calmette-Guerin Danish in select tissues of orally vaccinated feral swine (Sus scrofa ssp.)
title_fullStr Determining the persistence of Mycobacterium bovis bacille Calmette-Guerin Danish in select tissues of orally vaccinated feral swine (Sus scrofa ssp.)
title_full_unstemmed Determining the persistence of Mycobacterium bovis bacille Calmette-Guerin Danish in select tissues of orally vaccinated feral swine (Sus scrofa ssp.)
title_sort Determining the persistence of Mycobacterium bovis bacille Calmette-Guerin Danish in select tissues of orally vaccinated feral swine (Sus scrofa ssp.)
dc.creator.none.fl_str_mv Nol, Pauline
Robbe-Austerman, Suelee
Rhyan, Jack C.
McCollum, Matt P.
Triantis, Joni M.
Beltrán-Beck, Beatriz
Salman, Mo D.
author Nol, Pauline
author_facet Nol, Pauline
Robbe-Austerman, Suelee
Rhyan, Jack C.
McCollum, Matt P.
Triantis, Joni M.
Beltrán-Beck, Beatriz
Salman, Mo D.
author_role author
author2 Robbe-Austerman, Suelee
Rhyan, Jack C.
McCollum, Matt P.
Triantis, Joni M.
Beltrán-Beck, Beatriz
Salman, Mo D.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv European Commission
Department of Agriculture (US)
Universidad de Castilla La Mancha
Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Tissue persistence
Feral swine
BCG
Bovine tuberculosis
Vaccine
Mycobacterium bovis
topic Tissue persistence
Feral swine
BCG
Bovine tuberculosis
Vaccine
Mycobacterium bovis
description Mycobacterium bovis bacille Calmette–Guerin (BCG) is being considered for vaccination of feral swine (Sus scrofa ssp.). Since BCG is a live bacterium, evaluation of its safety and persistence in tissues is important. Fifteen feral swine received approximately 4.5 × 106 colony forming units of BCG Danish via oral bait. Four animals received bait without BCG. At 1, 3, 6, and 9 months post-vaccination, four vaccinates were euthanized. Non-vaccinates were euthanized at 9 months. Clinical signs were not noted in vaccinated pigs at any time. Tissues from all 20 pigs were culture-negative for mycobacteria. Based on our data, BCG is safe and appears not to persist in feral swine tissues after one month post-oral vaccination. However, further work must be performed at higher doses, and on a larger number of animals representing the target population, and further evaluation of persistence in tissues within the first month post-vaccination is needed.
publishDate 2016
dc.date.none.fl_str_mv 2016
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/173952
url http://hdl.handle.net/10261/173952
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1016/j.rvsc.2015.11.007
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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