Verbal episodic memory in children undergoing temporal lobe epilepsy surgery: a one-year follow-up study

Introduction. Verbal episodic memory (VEM) is often unimpaired in children with focal epilepsy undergoing left temporal lobe resections, unlike what we might expect in the adult brain. The latter findings suggest that epileptiform activity in early life disrupts memory system lateralization, leading...

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Autores: Bellido-Castillo E, López-Sala A, Aparicio J, Cuadras D, Palacio-Navarro A
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p25408
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=25408
Access Level:acceso abierto
Palabra clave:Drug resistant epilepsy
Episodic memory
Neuronal plasticity
Neurosurgery
Pediatric hospitals
Temporal lobe epilepsy
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spelling Verbal episodic memory in children undergoing temporal lobe epilepsy surgery: a one-year follow-up studyBellido-Castillo ELópez-Sala AAparicio JCuadras DPalacio-Navarro ADrug resistant epilepsyEpisodic memoryNeuronal plasticityNeurosurgeryPediatric hospitalsTemporal lobe epilepsyIntroduction. Verbal episodic memory (VEM) is often unimpaired in children with focal epilepsy undergoing left temporal lobe resections, unlike what we might expect in the adult brain. The latter findings suggest that epileptiform activity in early life disrupts memory system lateralization, leading to the development of bilateral memory representation. The present study aims to analyze whether the laterality of epilepsy is a major predictor for post-operative VEM prognosis in pediatric temporal lobe epilepsy (TLE) surgery. This research also pretends to provide evidence about the relationship of VEM performance with other relevant demographical and clinical factors such as sex, age at onset of seizures, age at surgery and duration of epilepsy, as well as to study the impact of presurgical VEM performance on postsurgical outcomes. Patients and methods. Pre-operative and one-year follow-up post-operative word-list recall scores from 25 children who underwent TLE surgery (left-sided, n = 11; right-sided, n = 14) were extracted from the Hospital Sant Joan de Deu database and were retrospectively analyzed. Results. No significant presurgical intergroup differences were found when comparing VEM scores by laterality of epilepsy (p > 0.5). Looking at the left TLE group, a high negative correlation was found between the onset age and the pre-operative long-term free recall score (rho = -0.72, p = 0.01). No significant pre- to post-operative intragroup changes were found regarding VEM performance, regardless of epilepsy laterality (left TLE group, p > 0.56; right TLE group, p > 0.12). Conclusions. The laterality of epilepsy does not show to be a significant factor in and of itself regarding presurgical VEM outcome and its prognosis one year after surgery, thus supporting the bilateral memory representation hypothesis. Furthermore, a younger age at onset of seizures seems to be related with a better pre-operative VEM performance, likely due to a more efficient reorganization of memory system induced by a greater brain plasticity at lower ages; however, this relationship has been only reported for the left-sided epilepsies in our sample.IMR PRESS2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=25408REVISTA DE NEUROLOGIAISSN: 02100010ISSNe: 15766578reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuEspañolinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p254082026-05-27T12:37:41Z
dc.title.none.fl_str_mv Verbal episodic memory in children undergoing temporal lobe epilepsy surgery: a one-year follow-up study
title Verbal episodic memory in children undergoing temporal lobe epilepsy surgery: a one-year follow-up study
spellingShingle Verbal episodic memory in children undergoing temporal lobe epilepsy surgery: a one-year follow-up study
Bellido-Castillo E
Drug resistant epilepsy
Episodic memory
Neuronal plasticity
Neurosurgery
Pediatric hospitals
Temporal lobe epilepsy
title_short Verbal episodic memory in children undergoing temporal lobe epilepsy surgery: a one-year follow-up study
title_full Verbal episodic memory in children undergoing temporal lobe epilepsy surgery: a one-year follow-up study
title_fullStr Verbal episodic memory in children undergoing temporal lobe epilepsy surgery: a one-year follow-up study
title_full_unstemmed Verbal episodic memory in children undergoing temporal lobe epilepsy surgery: a one-year follow-up study
title_sort Verbal episodic memory in children undergoing temporal lobe epilepsy surgery: a one-year follow-up study
dc.creator.none.fl_str_mv Bellido-Castillo E
López-Sala A
Aparicio J
Cuadras D
Palacio-Navarro A
author Bellido-Castillo E
author_facet Bellido-Castillo E
López-Sala A
Aparicio J
Cuadras D
Palacio-Navarro A
author_role author
author2 López-Sala A
Aparicio J
Cuadras D
Palacio-Navarro A
author2_role author
author
author
author
dc.subject.none.fl_str_mv Drug resistant epilepsy
Episodic memory
Neuronal plasticity
Neurosurgery
Pediatric hospitals
Temporal lobe epilepsy
topic Drug resistant epilepsy
Episodic memory
Neuronal plasticity
Neurosurgery
Pediatric hospitals
Temporal lobe epilepsy
description Introduction. Verbal episodic memory (VEM) is often unimpaired in children with focal epilepsy undergoing left temporal lobe resections, unlike what we might expect in the adult brain. The latter findings suggest that epileptiform activity in early life disrupts memory system lateralization, leading to the development of bilateral memory representation. The present study aims to analyze whether the laterality of epilepsy is a major predictor for post-operative VEM prognosis in pediatric temporal lobe epilepsy (TLE) surgery. This research also pretends to provide evidence about the relationship of VEM performance with other relevant demographical and clinical factors such as sex, age at onset of seizures, age at surgery and duration of epilepsy, as well as to study the impact of presurgical VEM performance on postsurgical outcomes. Patients and methods. Pre-operative and one-year follow-up post-operative word-list recall scores from 25 children who underwent TLE surgery (left-sided, n = 11; right-sided, n = 14) were extracted from the Hospital Sant Joan de Deu database and were retrospectively analyzed. Results. No significant presurgical intergroup differences were found when comparing VEM scores by laterality of epilepsy (p > 0.5). Looking at the left TLE group, a high negative correlation was found between the onset age and the pre-operative long-term free recall score (rho = -0.72, p = 0.01). No significant pre- to post-operative intragroup changes were found regarding VEM performance, regardless of epilepsy laterality (left TLE group, p > 0.56; right TLE group, p > 0.12). Conclusions. The laterality of epilepsy does not show to be a significant factor in and of itself regarding presurgical VEM outcome and its prognosis one year after surgery, thus supporting the bilateral memory representation hypothesis. Furthermore, a younger age at onset of seizures seems to be related with a better pre-operative VEM performance, likely due to a more efficient reorganization of memory system induced by a greater brain plasticity at lower ages; however, this relationship has been only reported for the left-sided epilepsies in our sample.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=25408
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=25408
dc.language.none.fl_str_mv Español
language_invalid_str_mv Español
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv IMR PRESS
publisher.none.fl_str_mv IMR PRESS
dc.source.none.fl_str_mv REVISTA DE NEUROLOGIA
ISSN: 02100010
ISSNe: 15766578
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
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