Bartonella Endocarditis in Spain
Blood culture negative endocarditis (BCNE) is frequent in infective endocarditis (IE). One of the causes of BCNE is fastidious microorganisms, such as Bartonella spp. The aim of this study was to describe the epidemiologic, clinical characteristics, management and outcomes of patients with Bartonell...
| Autores: | , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:292969 |
| Acceso en línea: | https://ddd.uab.cat/record/292969 https://dx.doi.org/urn:doi:10.3390/pathogens11050561 |
| Access Level: | acceso abierto |
| Palabra clave: | Infective endocarditis Blood culture negative endocarditis Bartonella endocarditis Bartonella spp |
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Bartonella Endocarditis in SpainCase Reports of 21 CasesGarcía-Álvarez, Lara|||0000-0002-6518-9698García-García, ConcepciónMunoz, Patricia|||0000-0001-5706-5583Fariñas-Álvarez, María del CarmenCuadra, Manuel GutiérrezFernández-Hidalgo, Nuria|||0000-0002-2115-344XGarcía-Vázquez, ElisaMoral-Escudero, EncarnaciónAlonso-Socas, María del MarGarcía-Rosado, DácilHidalgo-Tenorio, Carmen|||0000-0002-6394-5728Domınguez, Fernando|||0000-0001-8408-363XGoikoetxea, JosuneGainzarain, Juan CarlosRodríguez-Esteban, María ÁngelesBosch-Guerra, XerachOteo, José A.|||0000-0001-7080-6542Infective endocarditisBlood culture negative endocarditisBartonella endocarditisBartonella sppBlood culture negative endocarditis (BCNE) is frequent in infective endocarditis (IE). One of the causes of BCNE is fastidious microorganisms, such as Bartonella spp. The aim of this study was to describe the epidemiologic, clinical characteristics, management and outcomes of patients with Bartonella IE from the "Spanish Collaboration on Endocarditis-Grupo de Apoyo al Manejo de la Endocarditis infecciosa en España (GAMES)"cohort. Here we presented 21 cases of Bartonella IE. This represents 0.3% of a total of 5590 cases and 2% of the BCNE from the GAMES cohort. 62% were due to Bartonella henselae and 38% to Bartonella quintana. Cardiac failure was the main presenting form (61.5% in B. hensalae, 87.5% in B. quintana IE) and the aortic valve was affected in 85% of the cases (76% in B. henselae, 100% in B. quintana IE). Typical signs such as fever were recorded in less than 40% of patients. Echocardiography showed vegetations in 92% and 100% of the patients with B. henselae and B. quintana, respectively. Culture was positive only in one patient and the remaining were diagnosed by serology and PCR. PCR was the most useful tool allowing for diagnosis in 16 patients (100% of the studied valves). Serology, at titers recommended by guidelines, only coincided with PCR in 52.4%. Antimicrobial therapy, in different combinations, was used in all cases. Surgery was performed in 76% of the patients. No in-hospital mortality was observed. One-year mortality was 9.4%. This article remarks the importance for investigating the presence of Bartonella infection as causative agent in all BCNE since the diagnosis needs specific microbiological tools and patients could benefit of a specific treatment. 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/292969https://dx.doi.org/urn:doi:10.3390/pathogens11050561reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2929692026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Bartonella Endocarditis in Spain Case Reports of 21 Cases |
| title |
Bartonella Endocarditis in Spain |
| spellingShingle |
Bartonella Endocarditis in Spain García-Álvarez, Lara|||0000-0002-6518-9698 Infective endocarditis Blood culture negative endocarditis Bartonella endocarditis Bartonella spp |
| title_short |
Bartonella Endocarditis in Spain |
| title_full |
Bartonella Endocarditis in Spain |
| title_fullStr |
Bartonella Endocarditis in Spain |
| title_full_unstemmed |
Bartonella Endocarditis in Spain |
| title_sort |
Bartonella Endocarditis in Spain |
| dc.creator.none.fl_str_mv |
García-Álvarez, Lara|||0000-0002-6518-9698 García-García, Concepción Munoz, Patricia|||0000-0001-5706-5583 Fariñas-Álvarez, María del Carmen Cuadra, Manuel Gutiérrez Fernández-Hidalgo, Nuria|||0000-0002-2115-344X García-Vázquez, Elisa Moral-Escudero, Encarnación Alonso-Socas, María del Mar García-Rosado, Dácil Hidalgo-Tenorio, Carmen|||0000-0002-6394-5728 Domınguez, Fernando|||0000-0001-8408-363X Goikoetxea, Josune Gainzarain, Juan Carlos Rodríguez-Esteban, María Ángeles Bosch-Guerra, Xerach Oteo, José A.|||0000-0001-7080-6542 |
| author |
García-Álvarez, Lara|||0000-0002-6518-9698 |
| author_facet |
García-Álvarez, Lara|||0000-0002-6518-9698 García-García, Concepción Munoz, Patricia|||0000-0001-5706-5583 Fariñas-Álvarez, María del Carmen Cuadra, Manuel Gutiérrez Fernández-Hidalgo, Nuria|||0000-0002-2115-344X García-Vázquez, Elisa Moral-Escudero, Encarnación Alonso-Socas, María del Mar García-Rosado, Dácil Hidalgo-Tenorio, Carmen|||0000-0002-6394-5728 Domınguez, Fernando|||0000-0001-8408-363X Goikoetxea, Josune Gainzarain, Juan Carlos Rodríguez-Esteban, María Ángeles Bosch-Guerra, Xerach Oteo, José A.|||0000-0001-7080-6542 |
| author_role |
author |
| author2 |
García-García, Concepción Munoz, Patricia|||0000-0001-5706-5583 Fariñas-Álvarez, María del Carmen Cuadra, Manuel Gutiérrez Fernández-Hidalgo, Nuria|||0000-0002-2115-344X García-Vázquez, Elisa Moral-Escudero, Encarnación Alonso-Socas, María del Mar García-Rosado, Dácil Hidalgo-Tenorio, Carmen|||0000-0002-6394-5728 Domınguez, Fernando|||0000-0001-8408-363X Goikoetxea, Josune Gainzarain, Juan Carlos Rodríguez-Esteban, María Ángeles Bosch-Guerra, Xerach Oteo, José A.|||0000-0001-7080-6542 |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Infective endocarditis Blood culture negative endocarditis Bartonella endocarditis Bartonella spp |
| topic |
Infective endocarditis Blood culture negative endocarditis Bartonella endocarditis Bartonella spp |
| description |
Blood culture negative endocarditis (BCNE) is frequent in infective endocarditis (IE). One of the causes of BCNE is fastidious microorganisms, such as Bartonella spp. The aim of this study was to describe the epidemiologic, clinical characteristics, management and outcomes of patients with Bartonella IE from the "Spanish Collaboration on Endocarditis-Grupo de Apoyo al Manejo de la Endocarditis infecciosa en España (GAMES)"cohort. Here we presented 21 cases of Bartonella IE. This represents 0.3% of a total of 5590 cases and 2% of the BCNE from the GAMES cohort. 62% were due to Bartonella henselae and 38% to Bartonella quintana. Cardiac failure was the main presenting form (61.5% in B. hensalae, 87.5% in B. quintana IE) and the aortic valve was affected in 85% of the cases (76% in B. henselae, 100% in B. quintana IE). Typical signs such as fever were recorded in less than 40% of patients. Echocardiography showed vegetations in 92% and 100% of the patients with B. henselae and B. quintana, respectively. Culture was positive only in one patient and the remaining were diagnosed by serology and PCR. PCR was the most useful tool allowing for diagnosis in 16 patients (100% of the studied valves). Serology, at titers recommended by guidelines, only coincided with PCR in 52.4%. Antimicrobial therapy, in different combinations, was used in all cases. Surgery was performed in 76% of the patients. No in-hospital mortality was observed. One-year mortality was 9.4%. This article remarks the importance for investigating the presence of Bartonella infection as causative agent in all BCNE since the diagnosis needs specific microbiological tools and patients could benefit of a specific treatment. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2 2022-01-01 2022 2022-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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article |
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https://ddd.uab.cat/record/292969 https://dx.doi.org/urn:doi:10.3390/pathogens11050561 |
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https://ddd.uab.cat/record/292969 https://dx.doi.org/urn:doi:10.3390/pathogens11050561 |
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Inglés eng |
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Inglés |
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eng |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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