Epigenetics as a Therapeutic Target in Osteoarthritis

Osteoarthritis (OA) is a heterogenous, complex disease affecting the integrity of diarthrodial joints that, despite its high prevalence worldwide, lacks effective treatment. In recent years it has been discovered that epigenetics may play an important role in OA. Our objective is to review the curre...

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Autores: Nuñez Carro, Carmen, Blanco Blanco, Margarita, Villagrán Andrade, Karla Maurixi, Blanco García, Francisco, De Andrés González, Mª Carmen
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Servizo Galego de Saúde (SERGAS)
Repositorio:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/21519
Acceso en línea:https://portalcientifico.sergas.gal//documentos/640d5e77f0c92964f843ea4f
http://hdl.handle.net/20.500.11940/21519
Access Level:acceso abierto
Palabra clave:INIBIC
CHUAC
AS A Coruña
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spelling Epigenetics as a Therapeutic Target in OsteoarthritisNuñez Carro, CarmenBlanco Blanco, MargaritaVillagrán Andrade, Karla MaurixiBlanco García, FranciscoDe Andrés González, Mª CarmenINIBICCHUACCHUACAS A CoruñaCHUACAS A CoruñaINIBICOsteoarthritis (OA) is a heterogenous, complex disease affecting the integrity of diarthrodial joints that, despite its high prevalence worldwide, lacks effective treatment. In recent years it has been discovered that epigenetics may play an important role in OA. Our objective is to review the current knowledge of the three classical epigenetic mechanisms-DNA methylation, histone post-translational modifications (PTMs), and non-coding RNA (ncRNA) modifications, including microRNAs (miRNAs), circular RNAs (circRNAs), and long non-coding RNAs (lncRNAs)-in relation to the pathogenesis of OA and focusing on articular cartilage. The search for updated literature was carried out in the PubMed database. Evidence shows that dysregulation of numerous essential cartilage molecules is caused by aberrant epigenetic regulatory mechanisms, and it contributes to the development and progression of OA. This offers the opportunity to consider new candidates as therapeutic targets with the potential to attenuate OA or to be used as novel biomarkers of the disease.This study has been funded by Instituto de Salud Carlos III (ISCIII) through the project PI19/01213 and co-funded by the European Union, and grants IN607D2022/12 and IN607A 2021/7 from Xunta de Galicia, Axencia Galega de Innovacion GAIN. M.C.D.A is supported by the Miguel Servet program from Fondo Investigacion Sanitaria-Spain (CP18/00084).2023info:eu-repo/semantics/articlehttps://portalcientifico.sergas.gal//documentos/640d5e77f0c92964f843ea4fhttp://hdl.handle.net/20.500.11940/21519reponame:RUNA. Repositorio da Consellería de Sanidade e Sergasinstname:Servizo Galego de Saúde (SERGAS)Ingléshttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:runa.sergas.gal:20.500.11940/215192026-06-12T08:40:47Z
dc.title.none.fl_str_mv Epigenetics as a Therapeutic Target in Osteoarthritis
title Epigenetics as a Therapeutic Target in Osteoarthritis
spellingShingle Epigenetics as a Therapeutic Target in Osteoarthritis
Nuñez Carro, Carmen
INIBIC
CHUAC
CHUAC
AS A Coruña
CHUAC
AS A Coruña
INIBIC
title_short Epigenetics as a Therapeutic Target in Osteoarthritis
title_full Epigenetics as a Therapeutic Target in Osteoarthritis
title_fullStr Epigenetics as a Therapeutic Target in Osteoarthritis
title_full_unstemmed Epigenetics as a Therapeutic Target in Osteoarthritis
title_sort Epigenetics as a Therapeutic Target in Osteoarthritis
dc.creator.none.fl_str_mv Nuñez Carro, Carmen
Blanco Blanco, Margarita
Villagrán Andrade, Karla Maurixi
Blanco García, Francisco
De Andrés González, Mª Carmen
author Nuñez Carro, Carmen
author_facet Nuñez Carro, Carmen
Blanco Blanco, Margarita
Villagrán Andrade, Karla Maurixi
Blanco García, Francisco
De Andrés González, Mª Carmen
author_role author
author2 Blanco Blanco, Margarita
Villagrán Andrade, Karla Maurixi
Blanco García, Francisco
De Andrés González, Mª Carmen
author2_role author
author
author
author
dc.subject.none.fl_str_mv INIBIC
CHUAC
CHUAC
AS A Coruña
CHUAC
AS A Coruña
INIBIC
topic INIBIC
CHUAC
CHUAC
AS A Coruña
CHUAC
AS A Coruña
INIBIC
description Osteoarthritis (OA) is a heterogenous, complex disease affecting the integrity of diarthrodial joints that, despite its high prevalence worldwide, lacks effective treatment. In recent years it has been discovered that epigenetics may play an important role in OA. Our objective is to review the current knowledge of the three classical epigenetic mechanisms-DNA methylation, histone post-translational modifications (PTMs), and non-coding RNA (ncRNA) modifications, including microRNAs (miRNAs), circular RNAs (circRNAs), and long non-coding RNAs (lncRNAs)-in relation to the pathogenesis of OA and focusing on articular cartilage. The search for updated literature was carried out in the PubMed database. Evidence shows that dysregulation of numerous essential cartilage molecules is caused by aberrant epigenetic regulatory mechanisms, and it contributes to the development and progression of OA. This offers the opportunity to consider new candidates as therapeutic targets with the potential to attenuate OA or to be used as novel biomarkers of the disease.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://portalcientifico.sergas.gal//documentos/640d5e77f0c92964f843ea4f
http://hdl.handle.net/20.500.11940/21519
url https://portalcientifico.sergas.gal//documentos/640d5e77f0c92964f843ea4f
http://hdl.handle.net/20.500.11940/21519
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:RUNA. Repositorio da Consellería de Sanidade e Sergas
instname:Servizo Galego de Saúde (SERGAS)
instname_str Servizo Galego de Saúde (SERGAS)
reponame_str RUNA. Repositorio da Consellería de Sanidade e Sergas
collection RUNA. Repositorio da Consellería de Sanidade e Sergas
repository.name.fl_str_mv
repository.mail.fl_str_mv
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