Synthesis of new possible monoamine oxidase inhibitors

We have generated different resveratrol-coumarin hybrids with the aim of evaluate their biological applications and their pharmacological properties, particularly the inhibitory activity of monoamine oxidase enzyme. According to that, a first series of 3-aryl-4-hydroxycoumarins has been synthesized...

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Detalhes bibliográficos
Autores: Serra, Silvia, Matos, Maria João Correia Pinto Carvalho de, Delogu, Giovanna Lucia, Santana Penín, María Lourdes, Uriarte Villares, Eugenio
Tipo de documento: capítulo de livro
Data de publicação:2010
País:España
Recursos:Universidad de Santiago de Compostela (USC)
Repositório:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglês
OAI Identifier:oai:minerva.usc.gal:10347/26873
Acesso em linha:http://hdl.handle.net/10347/26873
Access Level:Acceso aberto
Descrição
Resumo:We have generated different resveratrol-coumarin hybrids with the aim of evaluate their biological applications and their pharmacological properties, particularly the inhibitory activity of monoamine oxidase enzyme. According to that, a first series of 3-aryl-4-hydroxycoumarins has been synthesized starting from aryl boronic acids and phenyliodonium zwitterions precursors by a palladium-catalyzed coupling reaction