Absorption and pharmacokinetics of green tea catechins in beagles
The present study evaluates for the first time in dogs, the kinetics of green tea catechins and their metabolic forms in plasma and urine. Ten beagles were administered 173 mg (12·35 mg/kg body weight) of catechins as a green tea extract, in capsules. Blood samples were collected during 24 h after i...
| Autores: | , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2008 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/54966 |
| Acesso em linha: | https://hdl.handle.net/2445/54966 |
| Access Level: | acceso abierto |
| Palavra-chave: | Antioxidants Farmacocinètica Biotransformació (Metabolisme) Te Absorció intestinal Flavonoides Gos Pharmacokinetics Biotransformation (Metabolism) Tea Intestinal absorption Flavonoids Dog |
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Absorption and pharmacokinetics of green tea catechins in beaglesMata Bilbao, María de LourdesAndrés Lacueva, Ma. CristinaRoura Carvajal, ElenaJáuregui Pallarés, OlgaEscribano Ferrer, ElviraTorre, CelinaLamuela Raventós, Rosa Ma.AntioxidantsFarmacocinèticaBiotransformació (Metabolisme)TeAbsorció intestinalFlavonoidesGosAntioxidantsPharmacokineticsBiotransformation (Metabolism)TeaIntestinal absorptionFlavonoidsDogThe present study evaluates for the first time in dogs, the kinetics of green tea catechins and their metabolic forms in plasma and urine. Ten beagles were administered 173 mg (12·35 mg/kg body weight) of catechins as a green tea extract, in capsules. Blood samples were collected during 24 h after intake and urine samples were collected during the following periods of time: 0-2, 2-6, 6-8 and 8-24 h. Two catechins with a galloyl moiety and three conjugated metabolites were detected in plasma. Most of the detected forms in plasma reached their maximum plasma concentration (Cmax) at around 1 h. Median Cmax for (2)-epigallocatechin-3-gallate (EGCG), (2)-epicatechin-3-gallate (ECG), (2)-epigallocatechin glucuronide (EGCglucuronide), (2)-epicatechin glucuronide (EC-glucuronide), (2)-epicatechin sulphate (EC sulphate) were 0·3 (range 0·1-1·9), 0·1 (range 0-0·4), 0·8 (range 0·2-3·9), 0·2 (range 0·1 1·7) and 1 (range 0·3-3·4) mmol/l, respectively. The areas under the plasma concentration v. time curves (AUC0!24) were 427 (range 102-1185) mmol/l £ min for EGC-glucuronide, 112 (range 53-919) mmol/l £ min for EC-sulphate, 71 (range 26-306) mmol/l £ min for EGCG, 40 (range 12-258) mmol/l £ min for EC-glucuronide and 14 (range 0·1-124) mmol/l £ min for ECG. The values of mean residence time (MRT0!24) were 5 (range 2-16), 2 (range 1-11), 10 (range 2-13), 3 (range 2-16) and 2·4 (range 1-18) h for EGCG, ECG, EGC-glucuronide, EC-glucuronide and EC sulphate, respectively. In urine, catechins were present as conjugated forms, suggesting bile excretion of EGCG and ECG. Green tea catechins are absorbed following an oral administration and EGC-glucuronide is the metabolic form that remains in the organism for a longer period of time, suggesting that this compound could suffer an enterohepatic cycle.Cambridge University Press2014201420082014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion7 p.application/pdfhttps://hdl.handle.net/2445/54966Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://dx.doi.org/10.1017/S0007114507898692British Journal of Nutrition, 2008, vol. 100, num. 3, p. 496-502http://dx.doi.org/10.1017/S0007114507898692(c) Cambridge University Press, 2008info:eu-repo/semantics/openAccessoai:recercat.cat:2445/549662026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Absorption and pharmacokinetics of green tea catechins in beagles |
| title |
Absorption and pharmacokinetics of green tea catechins in beagles |
| spellingShingle |
Absorption and pharmacokinetics of green tea catechins in beagles Mata Bilbao, María de Lourdes Antioxidants Farmacocinètica Biotransformació (Metabolisme) Te Absorció intestinal Flavonoides Gos Antioxidants Pharmacokinetics Biotransformation (Metabolism) Tea Intestinal absorption Flavonoids Dog |
| title_short |
Absorption and pharmacokinetics of green tea catechins in beagles |
| title_full |
Absorption and pharmacokinetics of green tea catechins in beagles |
| title_fullStr |
Absorption and pharmacokinetics of green tea catechins in beagles |
| title_full_unstemmed |
Absorption and pharmacokinetics of green tea catechins in beagles |
| title_sort |
Absorption and pharmacokinetics of green tea catechins in beagles |
| dc.creator.none.fl_str_mv |
Mata Bilbao, María de Lourdes Andrés Lacueva, Ma. Cristina Roura Carvajal, Elena Jáuregui Pallarés, Olga Escribano Ferrer, Elvira Torre, Celina Lamuela Raventós, Rosa Ma. |
| author |
Mata Bilbao, María de Lourdes |
| author_facet |
Mata Bilbao, María de Lourdes Andrés Lacueva, Ma. Cristina Roura Carvajal, Elena Jáuregui Pallarés, Olga Escribano Ferrer, Elvira Torre, Celina Lamuela Raventós, Rosa Ma. |
| author_role |
author |
| author2 |
Andrés Lacueva, Ma. Cristina Roura Carvajal, Elena Jáuregui Pallarés, Olga Escribano Ferrer, Elvira Torre, Celina Lamuela Raventós, Rosa Ma. |
| author2_role |
author author author author author author |
| dc.subject.none.fl_str_mv |
Antioxidants Farmacocinètica Biotransformació (Metabolisme) Te Absorció intestinal Flavonoides Gos Antioxidants Pharmacokinetics Biotransformation (Metabolism) Tea Intestinal absorption Flavonoids Dog |
| topic |
Antioxidants Farmacocinètica Biotransformació (Metabolisme) Te Absorció intestinal Flavonoides Gos Antioxidants Pharmacokinetics Biotransformation (Metabolism) Tea Intestinal absorption Flavonoids Dog |
| description |
The present study evaluates for the first time in dogs, the kinetics of green tea catechins and their metabolic forms in plasma and urine. Ten beagles were administered 173 mg (12·35 mg/kg body weight) of catechins as a green tea extract, in capsules. Blood samples were collected during 24 h after intake and urine samples were collected during the following periods of time: 0-2, 2-6, 6-8 and 8-24 h. Two catechins with a galloyl moiety and three conjugated metabolites were detected in plasma. Most of the detected forms in plasma reached their maximum plasma concentration (Cmax) at around 1 h. Median Cmax for (2)-epigallocatechin-3-gallate (EGCG), (2)-epicatechin-3-gallate (ECG), (2)-epigallocatechin glucuronide (EGCglucuronide), (2)-epicatechin glucuronide (EC-glucuronide), (2)-epicatechin sulphate (EC sulphate) were 0·3 (range 0·1-1·9), 0·1 (range 0-0·4), 0·8 (range 0·2-3·9), 0·2 (range 0·1 1·7) and 1 (range 0·3-3·4) mmol/l, respectively. The areas under the plasma concentration v. time curves (AUC0!24) were 427 (range 102-1185) mmol/l £ min for EGC-glucuronide, 112 (range 53-919) mmol/l £ min for EC-sulphate, 71 (range 26-306) mmol/l £ min for EGCG, 40 (range 12-258) mmol/l £ min for EC-glucuronide and 14 (range 0·1-124) mmol/l £ min for ECG. The values of mean residence time (MRT0!24) were 5 (range 2-16), 2 (range 1-11), 10 (range 2-13), 3 (range 2-16) and 2·4 (range 1-18) h for EGCG, ECG, EGC-glucuronide, EC-glucuronide and EC sulphate, respectively. In urine, catechins were present as conjugated forms, suggesting bile excretion of EGCG and ECG. Green tea catechins are absorbed following an oral administration and EGC-glucuronide is the metabolic form that remains in the organism for a longer period of time, suggesting that this compound could suffer an enterohepatic cycle. |
| publishDate |
2008 |
| dc.date.none.fl_str_mv |
2008 2014 2014 2014 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/54966 |
| url |
https://hdl.handle.net/2445/54966 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: http://dx.doi.org/10.1017/S0007114507898692 British Journal of Nutrition, 2008, vol. 100, num. 3, p. 496-502 http://dx.doi.org/10.1017/S0007114507898692 |
| dc.rights.none.fl_str_mv |
(c) Cambridge University Press, 2008 info:eu-repo/semantics/openAccess |
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(c) Cambridge University Press, 2008 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
7 p. application/pdf |
| dc.publisher.none.fl_str_mv |
Cambridge University Press |
| publisher.none.fl_str_mv |
Cambridge University Press |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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1869404107195809792 |
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15.812455 |