In-situ particles reorientation during magnetic hyperthermia application: Shape matters twice

Promising advances in nanomedicine such as magnetic hyperthermia rely on a precise control of the nanoparticle performance in the cellular environment. This constitutes a huge research challenge due to difficulties for achieving a remote control within the human body. Here we report on the significa...

Full description

Bibliographic Details
Authors: Simeonidis, Konstantinos, Morales, Maria del Puerto, Marciello, Marzia, ANGELAKERIS, MAKIS, Presa, Patricia de la, Lazaro-Carrillo, Ana, Tabero, Andrea, Villanueva, Angeles, Chubykalo-Fesenko, Oksana, Serantes Abalo, David
Format: article
Publication Date:2016
Country:España
Institution:Universidad de Santiago de Compostela (USC)
Repository:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Language:English
OAI Identifier:oai:minerva.usc.gal:10347/16304
Online Access:http://hdl.handle.net/10347/16304
Access Level:Open access
id ES_1a68c0657c812185f736e06cb33b9324
oai_identifier_str oai:minerva.usc.gal:10347/16304
network_acronym_str ES
network_name_str España
repository_id_str
spelling In-situ particles reorientation during magnetic hyperthermia application: Shape matters twiceSimeonidis, KonstantinosMorales, Maria del PuertoMarciello, MarziaANGELAKERIS, MAKISPresa, Patricia de laLazaro-Carrillo, AnaTabero, AndreaVillanueva, AngelesChubykalo-Fesenko, OksanaSerantes Abalo, DavidPromising advances in nanomedicine such as magnetic hyperthermia rely on a precise control of the nanoparticle performance in the cellular environment. This constitutes a huge research challenge due to difficulties for achieving a remote control within the human body. Here we report on the significant double role of the shape of ellipsoidal magnetic nanoparticles (nanorods) subjected to an external AC magnetic field: first, the heat release is increased due to the additional shape anisotropy; second, the rods dynamically reorientate in the orthogonal direction to the AC field direction. Importantly, the heating performance and the directional orientation occur in synergy and can be easily controlled by changing the AC field treatment duration, thus opening the pathway to combined hyperthermic/ mechanical nanoactuators for biomedicine. Preliminary studies demonstrate the high accumulation of nanorods into HeLa cells whereas viability analysis supports their low toxicity and the absence of apoptotic or necrotic cell death after 24 or 48h of incubationNature Publishing GroupUniversidade de Santiago de Compostela. Departamento de Física Aplicada20162016-12-0620162016-12-06journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10347/16304reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2© The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/163042026-06-15T12:47:27Z
dc.title.none.fl_str_mv In-situ particles reorientation during magnetic hyperthermia application: Shape matters twice
title In-situ particles reorientation during magnetic hyperthermia application: Shape matters twice
spellingShingle In-situ particles reorientation during magnetic hyperthermia application: Shape matters twice
Simeonidis, Konstantinos
title_short In-situ particles reorientation during magnetic hyperthermia application: Shape matters twice
title_full In-situ particles reorientation during magnetic hyperthermia application: Shape matters twice
title_fullStr In-situ particles reorientation during magnetic hyperthermia application: Shape matters twice
title_full_unstemmed In-situ particles reorientation during magnetic hyperthermia application: Shape matters twice
title_sort In-situ particles reorientation during magnetic hyperthermia application: Shape matters twice
dc.creator.none.fl_str_mv Simeonidis, Konstantinos
Morales, Maria del Puerto
Marciello, Marzia
ANGELAKERIS, MAKIS
Presa, Patricia de la
Lazaro-Carrillo, Ana
Tabero, Andrea
Villanueva, Angeles
Chubykalo-Fesenko, Oksana
Serantes Abalo, David
author Simeonidis, Konstantinos
author_facet Simeonidis, Konstantinos
Morales, Maria del Puerto
Marciello, Marzia
ANGELAKERIS, MAKIS
Presa, Patricia de la
Lazaro-Carrillo, Ana
Tabero, Andrea
Villanueva, Angeles
Chubykalo-Fesenko, Oksana
Serantes Abalo, David
author_role author
author2 Morales, Maria del Puerto
Marciello, Marzia
ANGELAKERIS, MAKIS
Presa, Patricia de la
Lazaro-Carrillo, Ana
Tabero, Andrea
Villanueva, Angeles
Chubykalo-Fesenko, Oksana
Serantes Abalo, David
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de Santiago de Compostela. Departamento de Física Aplicada
description Promising advances in nanomedicine such as magnetic hyperthermia rely on a precise control of the nanoparticle performance in the cellular environment. This constitutes a huge research challenge due to difficulties for achieving a remote control within the human body. Here we report on the significant double role of the shape of ellipsoidal magnetic nanoparticles (nanorods) subjected to an external AC magnetic field: first, the heat release is increased due to the additional shape anisotropy; second, the rods dynamically reorientate in the orthogonal direction to the AC field direction. Importantly, the heating performance and the directional orientation occur in synergy and can be easily controlled by changing the AC field treatment duration, thus opening the pathway to combined hyperthermic/ mechanical nanoactuators for biomedicine. Preliminary studies demonstrate the high accumulation of nanorods into HeLa cells whereas viability analysis supports their low toxicity and the absence of apoptotic or necrotic cell death after 24 or 48h of incubation
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-12-06
2016
2016-12-06
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10347/16304
url http://hdl.handle.net/10347/16304
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869404104486289408
score 15,811543

Similar Items