Association among polyphenol intake, uric acid, and hyperuricemia: A cross-sectional analysis in a population at high cardiovascular risk

Background Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess the association of the intake of different classes of polyphenols with serum uric acid and hyperurice...

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Autores: Rubín-García, María, Hernáez, Álvaro, PREDIMED‐Plus Trial Investigators
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/55619
Acceso en línea:http://hdl.handle.net/10230/55619
http://dx.doi.org/10.1161/JAHA.122.026053
Access Level:acceso abierto
Palabra clave:Hyperuricemia
Polyphenols
Uric acid
id ES_1a3b8dbdb79c5a937c505d4e084f4a3f
oai_identifier_str oai:recercat.cat:10230/55619
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Association among polyphenol intake, uric acid, and hyperuricemia: A cross-sectional analysis in a population at high cardiovascular risk
title Association among polyphenol intake, uric acid, and hyperuricemia: A cross-sectional analysis in a population at high cardiovascular risk
spellingShingle Association among polyphenol intake, uric acid, and hyperuricemia: A cross-sectional analysis in a population at high cardiovascular risk
Rubín-García, María
Hyperuricemia
Polyphenols
Uric acid
title_short Association among polyphenol intake, uric acid, and hyperuricemia: A cross-sectional analysis in a population at high cardiovascular risk
title_full Association among polyphenol intake, uric acid, and hyperuricemia: A cross-sectional analysis in a population at high cardiovascular risk
title_fullStr Association among polyphenol intake, uric acid, and hyperuricemia: A cross-sectional analysis in a population at high cardiovascular risk
title_full_unstemmed Association among polyphenol intake, uric acid, and hyperuricemia: A cross-sectional analysis in a population at high cardiovascular risk
title_sort Association among polyphenol intake, uric acid, and hyperuricemia: A cross-sectional analysis in a population at high cardiovascular risk
dc.creator.none.fl_str_mv Rubín-García, María
Hernáez, Álvaro
PREDIMED‐Plus Trial Investigators
author Rubín-García, María
author_facet Rubín-García, María
Hernáez, Álvaro
PREDIMED‐Plus Trial Investigators
author_role author
author2 Hernáez, Álvaro
PREDIMED‐Plus Trial Investigators
author2_role author
author
dc.subject.none.fl_str_mv Hyperuricemia
Polyphenols
Uric acid
topic Hyperuricemia
Polyphenols
Uric acid
description Background Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess the association of the intake of different classes of polyphenols with serum uric acid and hyperuricemia. Methods and Results This cross-sectional analysis involved baseline data of 6332 participants. Food polyphenol content was estimated by a validated semiquantitative food frequency questionnaire and from the Phenol-Explorer database. Multivariable-adjusted linear regression models with serum uric acid (milligrams per deciliter) as the outcome and polyphenol intake (quintiles) as the main independent variable were fitted. Cox regression models with constant follow-up time (t=1) were performed to estimate the prevalence ratios (PRs) of hyperuricemia (≥7 mg/dL in men and ≥6 mg/dL in women). An inverse association between the intake of the phenolic acid class (β coefficient, -0.17 mg/dL for quintile 5 versus quintile 1 [95% CI, -0.27 to -0.06]) and hydroxycinnamic acids (β coefficient, -0.19 [95% CI, -0.3 to -0.09]), alkylmethoxyphenols (β coefficient, -0.2 [95% CI, -0.31 to -0.1]), and methoxyphenols (β coefficient, -0.24 [95% CI, -0.34 to -0.13]) subclasses with serum uric acid levels and hyperuricemia (PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.80 [95% CI, 0.70-0.92]; and PR, 0.79 [95% CI, 0.69-0.91]; respectively) was found. The intake of hydroxybenzoic acids was directly and significantly associated with mean serum uric acid levels (β coefficient, 0.14 for quintile 5 versus quintile 1 [95% CI, 0.02-0.26]) but not with hyperuricemia. Conclusions In individuals with metabolic syndrome, a higher intake of some polyphenol subclasses (hydroxycinnamic acids, alkylmethoxyphenol, and methoxyphenol) was inversely associated with serum uric acid levels and hyperuricemia. Nevertheless, our findings warrant further research.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/55619
http://dx.doi.org/10.1161/JAHA.122.026053
url http://hdl.handle.net/10230/55619
http://dx.doi.org/10.1161/JAHA.122.026053
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv J Am Heart Assoc. 2022 Oct 18;11(20):e026053
info:eu-repo/grantAgreement/EC/FP7/340918
info:eu-repo/grantAgreement/ES/1PE/AGL2016–75329‐R
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
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dc.publisher.none.fl_str_mv American Hearth Association
publisher.none.fl_str_mv American Hearth Association
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Association among polyphenol intake, uric acid, and hyperuricemia: A cross-sectional analysis in a population at high cardiovascular riskRubín-García, MaríaHernáez, ÁlvaroPREDIMED‐Plus Trial InvestigatorsHyperuricemiaPolyphenolsUric acidBackground Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess the association of the intake of different classes of polyphenols with serum uric acid and hyperuricemia. Methods and Results This cross-sectional analysis involved baseline data of 6332 participants. Food polyphenol content was estimated by a validated semiquantitative food frequency questionnaire and from the Phenol-Explorer database. Multivariable-adjusted linear regression models with serum uric acid (milligrams per deciliter) as the outcome and polyphenol intake (quintiles) as the main independent variable were fitted. Cox regression models with constant follow-up time (t=1) were performed to estimate the prevalence ratios (PRs) of hyperuricemia (≥7 mg/dL in men and ≥6 mg/dL in women). An inverse association between the intake of the phenolic acid class (β coefficient, -0.17 mg/dL for quintile 5 versus quintile 1 [95% CI, -0.27 to -0.06]) and hydroxycinnamic acids (β coefficient, -0.19 [95% CI, -0.3 to -0.09]), alkylmethoxyphenols (β coefficient, -0.2 [95% CI, -0.31 to -0.1]), and methoxyphenols (β coefficient, -0.24 [95% CI, -0.34 to -0.13]) subclasses with serum uric acid levels and hyperuricemia (PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.80 [95% CI, 0.70-0.92]; and PR, 0.79 [95% CI, 0.69-0.91]; respectively) was found. The intake of hydroxybenzoic acids was directly and significantly associated with mean serum uric acid levels (β coefficient, 0.14 for quintile 5 versus quintile 1 [95% CI, 0.02-0.26]) but not with hyperuricemia. Conclusions In individuals with metabolic syndrome, a higher intake of some polyphenol subclasses (hydroxycinnamic acids, alkylmethoxyphenol, and methoxyphenol) was inversely associated with serum uric acid levels and hyperuricemia. Nevertheless, our findings warrant further research.The PREDIMED‐Plus trial was supported by the European Research Council (Advanced Research Grant 2013–2018, 340918) to Dr Martínez‐González, and the official funding agency for biomedical research of the Spanish government, Instituto de Salud Carlos III, through the Fondo de Investigación para la Salud, which is cofunded by the European Regional Development Fund (5 coordinated Fondo de Investigación para la Salud projects led by Dr. Salas‐Salvadó and Dr Vidal, including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/ 01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, and PI19/01332), the Especial Action Project titled Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED‐Plus grant to Dr Salas‐Salvadó, the Recercaixa grant to Dr Salas‐Salvadó (2013ACUP00194), a CICYT (Consejo Interinstitucional de Ciencia y Tecnología) grant (AGL2016–75329‐R), a grant from the Generalitat Valenciana (APOSTD/2019/136 to R.B.) and Generalitat de Catalunya (SGR‐2019 to R.E.), grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, and PI0137/2018), grants from the Generalitat Valenciana (PROMETEO/2017/017), a SEMERGEN (Sociedad Española de Médicos de Atención Primaria) grant, EU‐COST (European Cooperation in Science and Technology) Action CA16112, a grant of support to research groups number 35/2011 from the Balearic Islands Government, grants from IDISBA (Instituto de Investigación Sanitaria Islas Baleares), funds from the European Regional Development Fund (CIBEROBN CB06/03 and CB12/03) and from the European Commission (EAT2BENI‐CE_H2020_SFS2016), and the Spanish Ministry of Science, Innovation and Universities for the Formación de Profesorado Universitario (FPU17/06488 and FPU17/00785) contract. The funding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of the data; in the writing of the article, or in the decision to publish the results.American Hearth Association202320232022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/55619http://dx.doi.org/10.1161/JAHA.122.026053reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésJ Am Heart Assoc. 2022 Oct 18;11(20):e026053info:eu-repo/grantAgreement/EC/FP7/340918info:eu-repo/grantAgreement/ES/1PE/AGL2016–75329‐R© 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.http://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/556192026-05-29T05:05:01Z
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