Connectomic-genetic signatures in the cerebral small vessel disease
Small vessel disease (SVD) is a disorder that causes vascular lesions in the entire parenchyma of the human brain. At present, it is not well understood how primary and secondary damage interact to give rise to the complex scenario of white matter (WM) and grey matter (GM) lesions. Using novel cross...
| Autores: | , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:282281 |
| Acceso en línea: | https://ddd.uab.cat/record/282281 https://dx.doi.org/urn:doi:10.1016/j.nbd.2022.105671 |
| Access Level: | acceso abierto |
| Palabra clave: | Small vessel disease Grey matter White matter Neurodegeneration Connectomics Genetics Graph Theory |
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Connectomic-genetic signatures in the cerebral small vessel diseaseGutiérrez-Zúñiga, RaquelDiez, IbaiBueichekú, ElisendaKim, Chan-Mi|||0000-0001-5686-1668Orwig, WilliamMontal, Victor|||0000-0002-5714-9282Fuentes, Blanca|||0000-0002-0363-862XDíez-Tejedor, ExuperioGutiérrez-Fernández, MariaSepulcre, Jorge|||0000-0002-4199-2304Small vessel diseaseGrey matterWhite matterNeurodegenerationConnectomicsGeneticsGraph TheorySmall vessel disease (SVD) is a disorder that causes vascular lesions in the entire parenchyma of the human brain. At present, it is not well understood how primary and secondary damage interact to give rise to the complex scenario of white matter (WM) and grey matter (GM) lesions. Using novel cross-sectional and longitudinal connectomic approaches, we unveil the bidirectional nature of GM and WM changes, that is, primary cortical neurodegeneration that leads to secondary alterations in vascular border zones, and WM lesions that lead to secondary neurodegeneration in cortical projecting areas. We found this GM-WM interaction to be essential for executive cognitive performance. Moreover, we also observed that the interlocked degeneration of GM and WM over time associates with prototypical expression levels of genes potentially linked to SVD. Among these connectomic-genetic intersections, we found that the Androgen Receptor (AR) gene, is a particularly central candidate gene that might confer key vulnerability for brain lesion development in SVD. In conclusion, this study advances in the understanding of the bidirectional relationships between GM and WM lesions, primary and secondary vascular neurodegeneration, and sheds light on the genetic signatures of SVD.Universitat Autònoma de Barcelona 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/282281https://dx.doi.org/urn:doi:10.1016/j.nbd.2022.105671reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 CM18/00175open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2822812026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Connectomic-genetic signatures in the cerebral small vessel disease |
| title |
Connectomic-genetic signatures in the cerebral small vessel disease |
| spellingShingle |
Connectomic-genetic signatures in the cerebral small vessel disease Gutiérrez-Zúñiga, Raquel Small vessel disease Grey matter White matter Neurodegeneration Connectomics Genetics Graph Theory |
| title_short |
Connectomic-genetic signatures in the cerebral small vessel disease |
| title_full |
Connectomic-genetic signatures in the cerebral small vessel disease |
| title_fullStr |
Connectomic-genetic signatures in the cerebral small vessel disease |
| title_full_unstemmed |
Connectomic-genetic signatures in the cerebral small vessel disease |
| title_sort |
Connectomic-genetic signatures in the cerebral small vessel disease |
| dc.creator.none.fl_str_mv |
Gutiérrez-Zúñiga, Raquel Diez, Ibai Bueichekú, Elisenda Kim, Chan-Mi|||0000-0001-5686-1668 Orwig, William Montal, Victor|||0000-0002-5714-9282 Fuentes, Blanca|||0000-0002-0363-862X Díez-Tejedor, Exuperio Gutiérrez-Fernández, Maria Sepulcre, Jorge|||0000-0002-4199-2304 |
| author |
Gutiérrez-Zúñiga, Raquel |
| author_facet |
Gutiérrez-Zúñiga, Raquel Diez, Ibai Bueichekú, Elisenda Kim, Chan-Mi|||0000-0001-5686-1668 Orwig, William Montal, Victor|||0000-0002-5714-9282 Fuentes, Blanca|||0000-0002-0363-862X Díez-Tejedor, Exuperio Gutiérrez-Fernández, Maria Sepulcre, Jorge|||0000-0002-4199-2304 |
| author_role |
author |
| author2 |
Diez, Ibai Bueichekú, Elisenda Kim, Chan-Mi|||0000-0001-5686-1668 Orwig, William Montal, Victor|||0000-0002-5714-9282 Fuentes, Blanca|||0000-0002-0363-862X Díez-Tejedor, Exuperio Gutiérrez-Fernández, Maria Sepulcre, Jorge|||0000-0002-4199-2304 |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Small vessel disease Grey matter White matter Neurodegeneration Connectomics Genetics Graph Theory |
| topic |
Small vessel disease Grey matter White matter Neurodegeneration Connectomics Genetics Graph Theory |
| description |
Small vessel disease (SVD) is a disorder that causes vascular lesions in the entire parenchyma of the human brain. At present, it is not well understood how primary and secondary damage interact to give rise to the complex scenario of white matter (WM) and grey matter (GM) lesions. Using novel cross-sectional and longitudinal connectomic approaches, we unveil the bidirectional nature of GM and WM changes, that is, primary cortical neurodegeneration that leads to secondary alterations in vascular border zones, and WM lesions that lead to secondary neurodegeneration in cortical projecting areas. We found this GM-WM interaction to be essential for executive cognitive performance. Moreover, we also observed that the interlocked degeneration of GM and WM over time associates with prototypical expression levels of genes potentially linked to SVD. Among these connectomic-genetic intersections, we found that the Androgen Receptor (AR) gene, is a particularly central candidate gene that might confer key vulnerability for brain lesion development in SVD. In conclusion, this study advances in the understanding of the bidirectional relationships between GM and WM lesions, primary and secondary vascular neurodegeneration, and sheds light on the genetic signatures of SVD. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2 2022-01-01 2022 2022-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/282281 https://dx.doi.org/urn:doi:10.1016/j.nbd.2022.105671 |
| url |
https://ddd.uab.cat/record/282281 https://dx.doi.org/urn:doi:10.1016/j.nbd.2022.105671 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CM18/00175 |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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Dipòsit Digital de Documents de la UAB |
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