Zwitterionic 3D-printed non-immunogenic stealth microrobots

Microrobots offer transformative solutions for non-invasive medical interventions due to their small size and untethered operation inside the human body. However, they must face the immune system as a natural protection mechanism against foreign threats. Here, non-immunogenic stealth zwitterionic mi...

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Detalhes bibliográficos
Autores: Borrós, Salvador, Cabanach, Pol, Pena-Francesch, Abdon, Sheehan, Devin, Bozuyuk, Ugur, Yasa, Oncay, Sitti, Metin
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.14342/1014
Acesso em linha:http://hdl.handle.net/20.500.14342/1014
https://doi.org/10.1002/adma.202003013
Access Level:acceso abierto
Palavra-chave:Macròfags
Immunogenètica
Microrobots
Polimerització
Macrophages
Non-immunogenic properties
Stealth microrobots
Twophoton polymerization
Zwitterionic materials
575
616
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spelling Zwitterionic 3D-printed non-immunogenic stealth microrobotsBorrós, SalvadorCabanach, PolPena-Francesch, AbdonSheehan, DevinBozuyuk, UgurYasa, OncaySitti, MetinMacròfagsImmunogenèticaMicrorobotsPolimeritzacióMacrophagesNon-immunogenic propertiesStealth microrobotsTwophoton polymerizationZwitterionic materials575616Microrobots offer transformative solutions for non-invasive medical interventions due to their small size and untethered operation inside the human body. However, they must face the immune system as a natural protection mechanism against foreign threats. Here, non-immunogenic stealth zwitterionic microrobots that avoid recognition from immune cells are introduced. Fully zwitterionic photoresists are developed for two-photon polymerization 3D microprinting of hydrogel microrobots with ample functionalization: tunable mechanical properties, anti-biofouling and non-immunogenic properties, functionalization for magnetic actuation, encapsulation of biomolecules, and surface functionalization for drug delivery. Stealth microrobots avoid detection by macrophage cells of the innate immune system after exhaustive inspection (>90 hours), which has not been achieved in any microrobotic platform to date. These versatile zwitterionic materials eliminate a major roadblock in the development of biocompatible microrobots, and will serve as a toolbox of non-immunogenic materials for medical microrobot and other device technologies for bioengineering and biomedical applications.WileyUniversitat Ramon Llull. IQS2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.http://hdl.handle.net/20.500.14342/1014https://doi.org/10.1002/adma.202003013reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésAdvanced Materials. Vol.32, n.42 (2020), 2003013info:eu-repo/grantAgreement/MCIU/PN I+D/RTI2018-094734-B-C22info:eu-repo/grantAgreement/SUR del DEC/SGR/SGR 2017 1559info:eu-repo/grantAgreement/ERC/Advanced Grant/Grant No:834531info:eu-repo/grantAgreement/SUR del DEC i FSE/FI/2019 FI_B2 00165Attribution 4.0 International© L'autor/ahttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.14342/10142026-05-29T05:05:01Z
dc.title.none.fl_str_mv Zwitterionic 3D-printed non-immunogenic stealth microrobots
title Zwitterionic 3D-printed non-immunogenic stealth microrobots
spellingShingle Zwitterionic 3D-printed non-immunogenic stealth microrobots
Borrós, Salvador
Macròfags
Immunogenètica
Microrobots
Polimerització
Macrophages
Non-immunogenic properties
Stealth microrobots
Twophoton polymerization
Zwitterionic materials
575
616
title_short Zwitterionic 3D-printed non-immunogenic stealth microrobots
title_full Zwitterionic 3D-printed non-immunogenic stealth microrobots
title_fullStr Zwitterionic 3D-printed non-immunogenic stealth microrobots
title_full_unstemmed Zwitterionic 3D-printed non-immunogenic stealth microrobots
title_sort Zwitterionic 3D-printed non-immunogenic stealth microrobots
dc.creator.none.fl_str_mv Borrós, Salvador
Cabanach, Pol
Pena-Francesch, Abdon
Sheehan, Devin
Bozuyuk, Ugur
Yasa, Oncay
Sitti, Metin
author Borrós, Salvador
author_facet Borrós, Salvador
Cabanach, Pol
Pena-Francesch, Abdon
Sheehan, Devin
Bozuyuk, Ugur
Yasa, Oncay
Sitti, Metin
author_role author
author2 Cabanach, Pol
Pena-Francesch, Abdon
Sheehan, Devin
Bozuyuk, Ugur
Yasa, Oncay
Sitti, Metin
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Ramon Llull. IQS
dc.subject.none.fl_str_mv Macròfags
Immunogenètica
Microrobots
Polimerització
Macrophages
Non-immunogenic properties
Stealth microrobots
Twophoton polymerization
Zwitterionic materials
575
616
topic Macròfags
Immunogenètica
Microrobots
Polimerització
Macrophages
Non-immunogenic properties
Stealth microrobots
Twophoton polymerization
Zwitterionic materials
575
616
description Microrobots offer transformative solutions for non-invasive medical interventions due to their small size and untethered operation inside the human body. However, they must face the immune system as a natural protection mechanism against foreign threats. Here, non-immunogenic stealth zwitterionic microrobots that avoid recognition from immune cells are introduced. Fully zwitterionic photoresists are developed for two-photon polymerization 3D microprinting of hydrogel microrobots with ample functionalization: tunable mechanical properties, anti-biofouling and non-immunogenic properties, functionalization for magnetic actuation, encapsulation of biomolecules, and surface functionalization for drug delivery. Stealth microrobots avoid detection by macrophage cells of the innate immune system after exhaustive inspection (>90 hours), which has not been achieved in any microrobotic platform to date. These versatile zwitterionic materials eliminate a major roadblock in the development of biocompatible microrobots, and will serve as a toolbox of non-immunogenic materials for medical microrobot and other device technologies for bioengineering and biomedical applications.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.14342/1014
https://doi.org/10.1002/adma.202003013
url http://hdl.handle.net/20.500.14342/1014
https://doi.org/10.1002/adma.202003013
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Advanced Materials. Vol.32, n.42 (2020), 2003013
info:eu-repo/grantAgreement/MCIU/PN I+D/RTI2018-094734-B-C22
info:eu-repo/grantAgreement/SUR del DEC/SGR/SGR 2017 1559
info:eu-repo/grantAgreement/ERC/Advanced Grant/Grant No:834531
info:eu-repo/grantAgreement/SUR del DEC i FSE/FI/2019 FI_B2 00165
dc.rights.none.fl_str_mv Attribution 4.0 International
© L'autor/a
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
© L'autor/a
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869404089430835200
score 15.81155

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