Cervical Electrical Neuromodulation Effectively Enhances Hand Motor Output in Healthy Subjects by Engaging a Use-Dependent Intervention

Electrical enabling motor control (eEmc) through transcutaneous spinal cord stimulation is a non-invasive method that can modify the functional state of the sensory-motor system. We hypothesize that eEmc delivery, together with hand training, improves hand function in healthy subjects more than eith...

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Autores: Kumru, Hatice|||0000-0002-0501-1660, Flores de los Heros, Africa|||0000-0003-0720-2409, Rodríguez-Cañón, María|||0000-0003-4093-5292, Edgerton, Victor|||0000-0001-6534-1875, García-Alén, Loreto|||0000-0001-9910-9476, Benito-Penalva, Jesús|||0000-0003-1232-1808, Navarro, X. (Xavier)|||0000-0001-9849-902X, Gerasimenko, Yury P.|||0000-0002-9345-3791, García Alias, Guillermo|||0000-0003-0197-0503, Vidal, Joan|||0000-0002-3952-2442
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:236226
Acceso en línea:https://ddd.uab.cat/record/236226
https://dx.doi.org/urn:doi:10.3390/jcm10020195
Access Level:acceso abierto
Palabra clave:Transcutaneous spinal cord stimulation
Hand training
Combined intervention
Neuromodulation
Cervical spinal cord
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spelling Cervical Electrical Neuromodulation Effectively Enhances Hand Motor Output in Healthy Subjects by Engaging a Use-Dependent InterventionKumru, Hatice|||0000-0002-0501-1660Flores de los Heros, Africa|||0000-0003-0720-2409Rodríguez-Cañón, María|||0000-0003-4093-5292Edgerton, Victor|||0000-0001-6534-1875García-Alén, Loreto|||0000-0001-9910-9476Benito-Penalva, Jesús|||0000-0003-1232-1808Navarro, X. (Xavier)|||0000-0001-9849-902XGerasimenko, Yury P.|||0000-0002-9345-3791García Alias, Guillermo|||0000-0003-0197-0503Vidal, Joan|||0000-0002-3952-2442Transcutaneous spinal cord stimulationHand trainingCombined interventionNeuromodulationCervical spinal cordElectrical enabling motor control (eEmc) through transcutaneous spinal cord stimulation is a non-invasive method that can modify the functional state of the sensory-motor system. We hypothesize that eEmc delivery, together with hand training, improves hand function in healthy subjects more than either intervention alone by inducing plastic changes at spinal and cortical levels. Ten voluntary participants were included in the following three interventions: (i) hand grip training, (ii) eEmc, and (iii) eEmc with hand training. Functional evaluation included the box and blocks test (BBT) and hand grip maximum voluntary contraction (MVC), spinal and cortical motor evoked potential (sMEP and cMEP), and resting motor thresholds (RMT), short interval intracortical inhibition (SICI), and F wave in the abductor pollicis brevis muscle. eEmc combined with hand training retained MVC and increased F wave amplitude and persistency, reduced cortical RMT and facilitated cMEP amplitude. In contrast, eEmc alone only increased F wave amplitude, whereas hand training alone reduced MVC and increased cortical RMT and SICI. In conclusion, eEmc combined with hand grip training enhanced hand motor output and induced plastic changes at spinal and cortical level in healthy subjects when compared to either intervention alone. These data suggest that electrical neuromodulation changes spinal and, perhaps, supraspinal networks to a more malleable state, while a concomitant use-dependent mechanism drives these networks to a higher functional state. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/236226https://dx.doi.org/urn:doi:10.3390/jcm10020195reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19-01680European Commission https://doi.org/10.13039/501100000780 H2020-ERA-NET-NEURON/AC16-00034open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2362262026-06-06T12:50:31Z
dc.title.none.fl_str_mv Cervical Electrical Neuromodulation Effectively Enhances Hand Motor Output in Healthy Subjects by Engaging a Use-Dependent Intervention
title Cervical Electrical Neuromodulation Effectively Enhances Hand Motor Output in Healthy Subjects by Engaging a Use-Dependent Intervention
spellingShingle Cervical Electrical Neuromodulation Effectively Enhances Hand Motor Output in Healthy Subjects by Engaging a Use-Dependent Intervention
Kumru, Hatice|||0000-0002-0501-1660
Transcutaneous spinal cord stimulation
Hand training
Combined intervention
Neuromodulation
Cervical spinal cord
title_short Cervical Electrical Neuromodulation Effectively Enhances Hand Motor Output in Healthy Subjects by Engaging a Use-Dependent Intervention
title_full Cervical Electrical Neuromodulation Effectively Enhances Hand Motor Output in Healthy Subjects by Engaging a Use-Dependent Intervention
title_fullStr Cervical Electrical Neuromodulation Effectively Enhances Hand Motor Output in Healthy Subjects by Engaging a Use-Dependent Intervention
title_full_unstemmed Cervical Electrical Neuromodulation Effectively Enhances Hand Motor Output in Healthy Subjects by Engaging a Use-Dependent Intervention
title_sort Cervical Electrical Neuromodulation Effectively Enhances Hand Motor Output in Healthy Subjects by Engaging a Use-Dependent Intervention
dc.creator.none.fl_str_mv Kumru, Hatice|||0000-0002-0501-1660
Flores de los Heros, Africa|||0000-0003-0720-2409
Rodríguez-Cañón, María|||0000-0003-4093-5292
Edgerton, Victor|||0000-0001-6534-1875
García-Alén, Loreto|||0000-0001-9910-9476
Benito-Penalva, Jesús|||0000-0003-1232-1808
Navarro, X. (Xavier)|||0000-0001-9849-902X
Gerasimenko, Yury P.|||0000-0002-9345-3791
García Alias, Guillermo|||0000-0003-0197-0503
Vidal, Joan|||0000-0002-3952-2442
author Kumru, Hatice|||0000-0002-0501-1660
author_facet Kumru, Hatice|||0000-0002-0501-1660
Flores de los Heros, Africa|||0000-0003-0720-2409
Rodríguez-Cañón, María|||0000-0003-4093-5292
Edgerton, Victor|||0000-0001-6534-1875
García-Alén, Loreto|||0000-0001-9910-9476
Benito-Penalva, Jesús|||0000-0003-1232-1808
Navarro, X. (Xavier)|||0000-0001-9849-902X
Gerasimenko, Yury P.|||0000-0002-9345-3791
García Alias, Guillermo|||0000-0003-0197-0503
Vidal, Joan|||0000-0002-3952-2442
author_role author
author2 Flores de los Heros, Africa|||0000-0003-0720-2409
Rodríguez-Cañón, María|||0000-0003-4093-5292
Edgerton, Victor|||0000-0001-6534-1875
García-Alén, Loreto|||0000-0001-9910-9476
Benito-Penalva, Jesús|||0000-0003-1232-1808
Navarro, X. (Xavier)|||0000-0001-9849-902X
Gerasimenko, Yury P.|||0000-0002-9345-3791
García Alias, Guillermo|||0000-0003-0197-0503
Vidal, Joan|||0000-0002-3952-2442
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Transcutaneous spinal cord stimulation
Hand training
Combined intervention
Neuromodulation
Cervical spinal cord
topic Transcutaneous spinal cord stimulation
Hand training
Combined intervention
Neuromodulation
Cervical spinal cord
description Electrical enabling motor control (eEmc) through transcutaneous spinal cord stimulation is a non-invasive method that can modify the functional state of the sensory-motor system. We hypothesize that eEmc delivery, together with hand training, improves hand function in healthy subjects more than either intervention alone by inducing plastic changes at spinal and cortical levels. Ten voluntary participants were included in the following three interventions: (i) hand grip training, (ii) eEmc, and (iii) eEmc with hand training. Functional evaluation included the box and blocks test (BBT) and hand grip maximum voluntary contraction (MVC), spinal and cortical motor evoked potential (sMEP and cMEP), and resting motor thresholds (RMT), short interval intracortical inhibition (SICI), and F wave in the abductor pollicis brevis muscle. eEmc combined with hand training retained MVC and increased F wave amplitude and persistency, reduced cortical RMT and facilitated cMEP amplitude. In contrast, eEmc alone only increased F wave amplitude, whereas hand training alone reduced MVC and increased cortical RMT and SICI. In conclusion, eEmc combined with hand grip training enhanced hand motor output and induced plastic changes at spinal and cortical level in healthy subjects when compared to either intervention alone. These data suggest that electrical neuromodulation changes spinal and, perhaps, supraspinal networks to a more malleable state, while a concomitant use-dependent mechanism drives these networks to a higher functional state.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/236226
https://dx.doi.org/urn:doi:10.3390/jcm10020195
url https://ddd.uab.cat/record/236226
https://dx.doi.org/urn:doi:10.3390/jcm10020195
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19-01680
European Commission https://doi.org/10.13039/501100000780 H2020-ERA-NET-NEURON/AC16-00034
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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