The Evaluation of Optic Nerves Using 7 Tesla 'Silent' Zero Echo Time Imaging in Patients with Leber's Hereditary Optic Neuropathy with or without Idebenone Treatment

Magnetic Resonance Imaging (MRI) of the Optic Nerve is difficult due to the fine extended nature of the structure, strong local magnetic field distortions induced by anatomy, and large motion artefacts associated with eye movement. To address these problems we used a Zero Echo Time (ZTE) MRI sequenc...

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Autores: Grochowski, Cezary, Symms, Mark, Jonak, Kamil, Krukow, Pawel, Wood, Tobias C., Ljungberg, Emil, Enseñat Nora, Joaquim, Nowomiejska, Katarzyna, Rejdak, Robert, Maciejewski, Ryszard, Barker, Gareth J.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/176372
Acceso en línea:https://hdl.handle.net/2445/176372
Access Level:acceso abierto
Palabra clave:Ressonància magnètica
Nervi òptic
Magnetic resonance
Optic nerve
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spelling The Evaluation of Optic Nerves Using 7 Tesla 'Silent' Zero Echo Time Imaging in Patients with Leber's Hereditary Optic Neuropathy with or without Idebenone TreatmentGrochowski, CezarySymms, MarkJonak, KamilKrukow, PawelWood, Tobias C.Ljungberg, EmilEnseñat Nora, JoaquimNowomiejska, KatarzynaRejdak, RobertMaciejewski, RyszardBarker, Gareth J.Ressonància magnèticaNervi òpticMagnetic resonanceOptic nerveMagnetic Resonance Imaging (MRI) of the Optic Nerve is difficult due to the fine extended nature of the structure, strong local magnetic field distortions induced by anatomy, and large motion artefacts associated with eye movement. To address these problems we used a Zero Echo Time (ZTE) MRI sequence with an Adiabatic SPectral Inversion Recovery (ASPIR) fat suppression pulse which also imbues the images with Magnetisation Transfer contrast. We investigated an application of the sequence for imaging the optic nerve in subjects with Leber's hereditary optic neuropathy (LHON). Of particular note is the sequence's near-silent operation, which can enhance image quality of the optic nerve by reducing the occurrence of involuntary saccades induced during Magnetic Resonance (MR) scanning.MDPI2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/176372Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/jcm9041112Journal of Clinical Medicine, 2020, vol. 9, num. 4, p. 1112https://doi.org/10.3390/jcm9041112cc-by (c) Grochowski, Cezary et al., 2020http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1763722026-05-27T06:46:51Z
dc.title.none.fl_str_mv The Evaluation of Optic Nerves Using 7 Tesla 'Silent' Zero Echo Time Imaging in Patients with Leber's Hereditary Optic Neuropathy with or without Idebenone Treatment
title The Evaluation of Optic Nerves Using 7 Tesla 'Silent' Zero Echo Time Imaging in Patients with Leber's Hereditary Optic Neuropathy with or without Idebenone Treatment
spellingShingle The Evaluation of Optic Nerves Using 7 Tesla 'Silent' Zero Echo Time Imaging in Patients with Leber's Hereditary Optic Neuropathy with or without Idebenone Treatment
Grochowski, Cezary
Ressonància magnètica
Nervi òptic
Magnetic resonance
Optic nerve
title_short The Evaluation of Optic Nerves Using 7 Tesla 'Silent' Zero Echo Time Imaging in Patients with Leber's Hereditary Optic Neuropathy with or without Idebenone Treatment
title_full The Evaluation of Optic Nerves Using 7 Tesla 'Silent' Zero Echo Time Imaging in Patients with Leber's Hereditary Optic Neuropathy with or without Idebenone Treatment
title_fullStr The Evaluation of Optic Nerves Using 7 Tesla 'Silent' Zero Echo Time Imaging in Patients with Leber's Hereditary Optic Neuropathy with or without Idebenone Treatment
title_full_unstemmed The Evaluation of Optic Nerves Using 7 Tesla 'Silent' Zero Echo Time Imaging in Patients with Leber's Hereditary Optic Neuropathy with or without Idebenone Treatment
title_sort The Evaluation of Optic Nerves Using 7 Tesla 'Silent' Zero Echo Time Imaging in Patients with Leber's Hereditary Optic Neuropathy with or without Idebenone Treatment
dc.creator.none.fl_str_mv Grochowski, Cezary
Symms, Mark
Jonak, Kamil
Krukow, Pawel
Wood, Tobias C.
Ljungberg, Emil
Enseñat Nora, Joaquim
Nowomiejska, Katarzyna
Rejdak, Robert
Maciejewski, Ryszard
Barker, Gareth J.
author Grochowski, Cezary
author_facet Grochowski, Cezary
Symms, Mark
Jonak, Kamil
Krukow, Pawel
Wood, Tobias C.
Ljungberg, Emil
Enseñat Nora, Joaquim
Nowomiejska, Katarzyna
Rejdak, Robert
Maciejewski, Ryszard
Barker, Gareth J.
author_role author
author2 Symms, Mark
Jonak, Kamil
Krukow, Pawel
Wood, Tobias C.
Ljungberg, Emil
Enseñat Nora, Joaquim
Nowomiejska, Katarzyna
Rejdak, Robert
Maciejewski, Ryszard
Barker, Gareth J.
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ressonància magnètica
Nervi òptic
Magnetic resonance
Optic nerve
topic Ressonància magnètica
Nervi òptic
Magnetic resonance
Optic nerve
description Magnetic Resonance Imaging (MRI) of the Optic Nerve is difficult due to the fine extended nature of the structure, strong local magnetic field distortions induced by anatomy, and large motion artefacts associated with eye movement. To address these problems we used a Zero Echo Time (ZTE) MRI sequence with an Adiabatic SPectral Inversion Recovery (ASPIR) fat suppression pulse which also imbues the images with Magnetisation Transfer contrast. We investigated an application of the sequence for imaging the optic nerve in subjects with Leber's hereditary optic neuropathy (LHON). Of particular note is the sequence's near-silent operation, which can enhance image quality of the optic nerve by reducing the occurrence of involuntary saccades induced during Magnetic Resonance (MR) scanning.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/176372
url https://hdl.handle.net/2445/176372
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/jcm9041112
Journal of Clinical Medicine, 2020, vol. 9, num. 4, p. 1112
https://doi.org/10.3390/jcm9041112
dc.rights.none.fl_str_mv cc-by (c) Grochowski, Cezary et al., 2020
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Grochowski, Cezary et al., 2020
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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