Cobalt(III)-py(2)en systems as potential carriers of beta-ketoester-based ligands
Two cobalt(III) complexes containing different β-ketoesters, namely [CoIII(L1)(py2en)](ClO4)2·H2O (1) and [CoIII(L2)(py2en)](ClO4)2 (2) (py2en = N,N′-bis(pyridin-2-ylmethyl)ethylenediamine; L1− = methylacetoacetate; L2− = ethyl 4-chloroacetoacetate) have been prepared and investigated as prototypes...
| Autores: | , , , , , , , , , |
|---|---|
| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2023 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositório: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/219360 |
| Acesso em linha: | https://hdl.handle.net/2445/219360 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Cobalt ADN Lligands DNA Ligands |
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Cobalt(III)-py(2)en systems as potential carriers of beta-ketoester-based ligandsPalmeira-Mello, Marcos V.Caballero Hernández, Ana BelénHerrera Ramírez, PiedadCosta, A.R.Santana, S.S.Guedes, G.P.Caubet, AmparoBatista, A.A.Gámez Enamorado, PatrickLanznaster, M.CobaltADNLligandsCobaltDNALigandsTwo cobalt(III) complexes containing different β-ketoesters, namely [CoIII(L1)(py2en)](ClO4)2·H2O (1) and [CoIII(L2)(py2en)](ClO4)2 (2) (py2en = N,N′-bis(pyridin-2-ylmethyl)ethylenediamine; L1− = methylacetoacetate; L2− = ethyl 4-chloroacetoacetate) have been prepared and investigated as prototypes of bioreductive prodrugs. The presence of β-ketoester and py2en ligands in 1 and 2, as well as the perchlorate counterions, was supported by IR spectroscopy and CHN elemental analysis. The composition molecular structure of both complexes was confirmed by NMR spectroscopy and ESI mass spectrometry. Structural information was also obtained for 2 via X-ray diffraction analysis. The redox properties indicate that 1 and 2 are suitable for reduction under biological conditions. Investigation of DNA-interacting suggest that 1 and 2 bind DNA via electrostatic forces. Both complexes may be employed as possible platforms for the delivery of biologically active compounds, since their reaction with ascorbic acid in PBS at pH 6.2 and 7.4 at 37°C results in the release of the β-ketoester ligands upon Co(III)/Co(II) reduction.Elsevier B.V.2025202520232025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfhttps://hdl.handle.net/2445/219360Articles publicats en revistes (Química Inorgànica i Orgànica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.jinorgbio.2023.112345Journal of Inorganic Biochemistry, 2023, vol. 248, p. 112345https://doi.org/10.1016/j.jinorgbio.2023.112345cc-by-nc-nd (c) Palmeira-Mello, Marcos V. et al., 2023http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2193602026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Cobalt(III)-py(2)en systems as potential carriers of beta-ketoester-based ligands |
| title |
Cobalt(III)-py(2)en systems as potential carriers of beta-ketoester-based ligands |
| spellingShingle |
Cobalt(III)-py(2)en systems as potential carriers of beta-ketoester-based ligands Palmeira-Mello, Marcos V. Cobalt ADN Lligands Cobalt DNA Ligands |
| title_short |
Cobalt(III)-py(2)en systems as potential carriers of beta-ketoester-based ligands |
| title_full |
Cobalt(III)-py(2)en systems as potential carriers of beta-ketoester-based ligands |
| title_fullStr |
Cobalt(III)-py(2)en systems as potential carriers of beta-ketoester-based ligands |
| title_full_unstemmed |
Cobalt(III)-py(2)en systems as potential carriers of beta-ketoester-based ligands |
| title_sort |
Cobalt(III)-py(2)en systems as potential carriers of beta-ketoester-based ligands |
| dc.creator.none.fl_str_mv |
Palmeira-Mello, Marcos V. Caballero Hernández, Ana Belén Herrera Ramírez, Piedad Costa, A.R. Santana, S.S. Guedes, G.P. Caubet, Amparo Batista, A.A. Gámez Enamorado, Patrick Lanznaster, M. |
| author |
Palmeira-Mello, Marcos V. |
| author_facet |
Palmeira-Mello, Marcos V. Caballero Hernández, Ana Belén Herrera Ramírez, Piedad Costa, A.R. Santana, S.S. Guedes, G.P. Caubet, Amparo Batista, A.A. Gámez Enamorado, Patrick Lanznaster, M. |
| author_role |
author |
| author2 |
Caballero Hernández, Ana Belén Herrera Ramírez, Piedad Costa, A.R. Santana, S.S. Guedes, G.P. Caubet, Amparo Batista, A.A. Gámez Enamorado, Patrick Lanznaster, M. |
| author2_role |
author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Cobalt ADN Lligands Cobalt DNA Ligands |
| topic |
Cobalt ADN Lligands Cobalt DNA Ligands |
| description |
Two cobalt(III) complexes containing different β-ketoesters, namely [CoIII(L1)(py2en)](ClO4)2·H2O (1) and [CoIII(L2)(py2en)](ClO4)2 (2) (py2en = N,N′-bis(pyridin-2-ylmethyl)ethylenediamine; L1− = methylacetoacetate; L2− = ethyl 4-chloroacetoacetate) have been prepared and investigated as prototypes of bioreductive prodrugs. The presence of β-ketoester and py2en ligands in 1 and 2, as well as the perchlorate counterions, was supported by IR spectroscopy and CHN elemental analysis. The composition molecular structure of both complexes was confirmed by NMR spectroscopy and ESI mass spectrometry. Structural information was also obtained for 2 via X-ray diffraction analysis. The redox properties indicate that 1 and 2 are suitable for reduction under biological conditions. Investigation of DNA-interacting suggest that 1 and 2 bind DNA via electrostatic forces. Both complexes may be employed as possible platforms for the delivery of biologically active compounds, since their reaction with ascorbic acid in PBS at pH 6.2 and 7.4 at 37°C results in the release of the β-ketoester ligands upon Co(III)/Co(II) reduction. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2025 2025 2025 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/219360 |
| url |
https://hdl.handle.net/2445/219360 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.1016/j.jinorgbio.2023.112345 Journal of Inorganic Biochemistry, 2023, vol. 248, p. 112345 https://doi.org/10.1016/j.jinorgbio.2023.112345 |
| dc.rights.none.fl_str_mv |
cc-by-nc-nd (c) Palmeira-Mello, Marcos V. et al., 2023 http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
cc-by-nc-nd (c) Palmeira-Mello, Marcos V. et al., 2023 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
11 p. application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier B.V. |
| publisher.none.fl_str_mv |
Elsevier B.V. |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Química Inorgànica i Orgànica) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str |
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| reponame_str |
Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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