Alterations in DRBD3 Ribonucleoprotein Complexes in Response to Stress in Trypanosoma brucei

AME and MC were jointly funded by the Royal Society Joint Project grant, grant number 2008/R2; AME was funded by Spanish Plan Nacional, grant number BFU 2009-07510; MC was funded by The Wellcome Trust, grant number 085956/Z/08/Z. The funders had no role in study design, data collection and analysis,...

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Authors: Fernández-Moya, Sandra Maria, García-Pérez, Angélica, Kramer, Susanne, Carrington, Mark, Estévez, Antonio M.
Format: article
Publication Date:2012
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.12328/4623
Online Access:http://hdl.handle.net/20.500.12328/4623
https://dx.doi.org/10.1371/journal.pone.0048870
Access Level:Open access
Keyword:ARN
RNA
61
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oai_identifier_str oai:recercat.cat:20.500.12328/4623
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spelling Alterations in DRBD3 Ribonucleoprotein Complexes in Response to Stress in Trypanosoma bruceiFernández-Moya, Sandra MariaGarcía-Pérez, AngélicaKramer, SusanneCarrington, MarkEstévez, Antonio M.ARNRNA61AME and MC were jointly funded by the Royal Society Joint Project grant, grant number 2008/R2; AME was funded by Spanish Plan Nacional, grant number BFU 2009-07510; MC was funded by The Wellcome Trust, grant number 085956/Z/08/Z. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Regulation of RNA polymerase II transcription initiation is apparently absent in trypanosomes. Instead, these eukaryotes control gene expression mainly at the post-transcriptional level. Regulation is exerted through the action of numerous RNA-binding proteins that modulate mRNA processing, turnover, translation and localization. In this work we show that the RNA-binding protein DRBD3 resides in the cytoplasm, but localizes to the nucleus upon oxidative challenge and to stress granules under starvation conditions. DRBD3 associates with other proteins to form a complex, the composition of which is altered by cellular stress. Interestingly, target mRNAs remain bound to DRBD3 under stress conditions. Our results suggest that DRBD3 transports regulated mRNAs within the cell in the form of ribonucleoprotein complexes that are remodeled in response to environmental cues.info:eu-repo/semantics/publishedVersionPLOS2012info:eu-repo/semantics/article10http://hdl.handle.net/20.500.12328/4623https://dx.doi.org/10.1371/journal.pone.0048870reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésPLOS One7;112012 Fernández-Moya et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.12328/46232026-05-29T05:05:01Z
dc.title.none.fl_str_mv Alterations in DRBD3 Ribonucleoprotein Complexes in Response to Stress in Trypanosoma brucei
title Alterations in DRBD3 Ribonucleoprotein Complexes in Response to Stress in Trypanosoma brucei
spellingShingle Alterations in DRBD3 Ribonucleoprotein Complexes in Response to Stress in Trypanosoma brucei
Fernández-Moya, Sandra Maria
ARN
RNA
61
title_short Alterations in DRBD3 Ribonucleoprotein Complexes in Response to Stress in Trypanosoma brucei
title_full Alterations in DRBD3 Ribonucleoprotein Complexes in Response to Stress in Trypanosoma brucei
title_fullStr Alterations in DRBD3 Ribonucleoprotein Complexes in Response to Stress in Trypanosoma brucei
title_full_unstemmed Alterations in DRBD3 Ribonucleoprotein Complexes in Response to Stress in Trypanosoma brucei
title_sort Alterations in DRBD3 Ribonucleoprotein Complexes in Response to Stress in Trypanosoma brucei
dc.creator.none.fl_str_mv Fernández-Moya, Sandra Maria
García-Pérez, Angélica
Kramer, Susanne
Carrington, Mark
Estévez, Antonio M.
author Fernández-Moya, Sandra Maria
author_facet Fernández-Moya, Sandra Maria
García-Pérez, Angélica
Kramer, Susanne
Carrington, Mark
Estévez, Antonio M.
author_role author
author2 García-Pérez, Angélica
Kramer, Susanne
Carrington, Mark
Estévez, Antonio M.
author2_role author
author
author
author
dc.subject.none.fl_str_mv ARN
RNA
61
topic ARN
RNA
61
description AME and MC were jointly funded by the Royal Society Joint Project grant, grant number 2008/R2; AME was funded by Spanish Plan Nacional, grant number BFU 2009-07510; MC was funded by The Wellcome Trust, grant number 085956/Z/08/Z. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12328/4623
https://dx.doi.org/10.1371/journal.pone.0048870
url http://hdl.handle.net/20.500.12328/4623
https://dx.doi.org/10.1371/journal.pone.0048870
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv PLOS One
7;11
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10
dc.publisher.none.fl_str_mv PLOS
publisher.none.fl_str_mv PLOS
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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