Cord Blood IL-12 Confers Protection to Clinical Malaria in Early Childhood Life

Using a well-designed longitudinal cohort, we aimed to identify cytokines that were protective against malaria and to explore how they were influenced by genetic and immunological factors. 349 Mozambican pregnant women and their newborn babies were recruited and followed up for malaria outcomes unti...

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Detalles Bibliográficos
Autores: Song, Yong, Aguilar, Ruth, Guo, Jing, Manaca, Maria Nélia, Nhabomba, Augusto J., Berthoud, Tamara, Khoo, Siew-Kim, Wiertsema, Selma, Barbosa, Arnoldo, Quintó, Llorenç, Laing, Ingrid, Mayor Aparicio, Alfredo Gabriel, Guinovart, Caterina, Alonso, Pedro, LeSouëf, Peter N., Dobaño, Carlota, 1969-, Zhang, Guicheng (Brad)
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/134603
Acceso en línea:https://hdl.handle.net/2445/134603
Access Level:acceso abierto
Palabra clave:Malària
Cordó umbilical
Infància
Malaria
Umbilical cord
Childhood
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spelling Cord Blood IL-12 Confers Protection to Clinical Malaria in Early Childhood LifeSong, YongAguilar, RuthGuo, JingManaca, Maria NéliaNhabomba, Augusto J.Berthoud, TamaraKhoo, Siew-KimWiertsema, SelmaBarbosa, ArnoldoQuintó, LlorençLaing, IngridMayor Aparicio, Alfredo GabrielGuinovart, CaterinaAlonso, PedroLeSouëf, Peter N.Dobaño, Carlota, 1969-Zhang, Guicheng (Brad)MalàriaCordó umbilicalInfànciaMalariaUmbilical cordChildhoodUsing a well-designed longitudinal cohort, we aimed to identify cytokines that were protective against malaria and to explore how they were influenced by genetic and immunological factors. 349 Mozambican pregnant women and their newborn babies were recruited and followed up for malaria outcomes until 24 months of age. Six Th1 cytokines in cord blood were screened for correlation with malaria incidence, of which IL-12 was selected for further analyses. We genotyped IL-12 polymorphisms in children/mothers and evaluated the genotype-phenotype associations and genetic effects on IL-12 levels. Maternal IL-12 concentrations were also investigated in relation to Plasmodium infections and cord blood IL-12 levels. Our data showed that high background IL-12 levels were prospectively associated with a low incidence of clinical malaria, while IL-12 production after parasite stimulation had the opposite effect on malaria incidence. IL-12 genotypes (IL-12b rs2288831/rs17860508) and the haplotype CGTTAGAG distribution were related to malaria susceptibility and background IL-12 levels. Maternal genotypes also exhibited an evident impact on host genotype-phenotype associations. Finally, a positive correlation in background IL-12 levels between maternal and cord blood was identified. Thus, cord blood background IL-12 concentrations are important for protecting children from clinical malaria, likely mediated by both genotypes (children&mothers) and maternal immunity.Nature Publishing Group2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/134603Articles publicats en revistes (ISGlobal)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1038/s41598-018-29179-yScientific Reports, 2018, vol. 8http://dx.doi.org/10.1038/s41598-018-29179-ycc by (c) Song et al., 2018http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1346032026-05-27T06:46:51Z
dc.title.none.fl_str_mv Cord Blood IL-12 Confers Protection to Clinical Malaria in Early Childhood Life
title Cord Blood IL-12 Confers Protection to Clinical Malaria in Early Childhood Life
spellingShingle Cord Blood IL-12 Confers Protection to Clinical Malaria in Early Childhood Life
Song, Yong
Malària
Cordó umbilical
Infància
Malaria
Umbilical cord
Childhood
title_short Cord Blood IL-12 Confers Protection to Clinical Malaria in Early Childhood Life
title_full Cord Blood IL-12 Confers Protection to Clinical Malaria in Early Childhood Life
title_fullStr Cord Blood IL-12 Confers Protection to Clinical Malaria in Early Childhood Life
title_full_unstemmed Cord Blood IL-12 Confers Protection to Clinical Malaria in Early Childhood Life
title_sort Cord Blood IL-12 Confers Protection to Clinical Malaria in Early Childhood Life
dc.creator.none.fl_str_mv Song, Yong
Aguilar, Ruth
Guo, Jing
Manaca, Maria Nélia
Nhabomba, Augusto J.
Berthoud, Tamara
Khoo, Siew-Kim
Wiertsema, Selma
Barbosa, Arnoldo
Quintó, Llorenç
Laing, Ingrid
Mayor Aparicio, Alfredo Gabriel
Guinovart, Caterina
Alonso, Pedro
LeSouëf, Peter N.
Dobaño, Carlota, 1969-
Zhang, Guicheng (Brad)
author Song, Yong
author_facet Song, Yong
Aguilar, Ruth
Guo, Jing
Manaca, Maria Nélia
Nhabomba, Augusto J.
Berthoud, Tamara
Khoo, Siew-Kim
Wiertsema, Selma
Barbosa, Arnoldo
Quintó, Llorenç
Laing, Ingrid
Mayor Aparicio, Alfredo Gabriel
Guinovart, Caterina
Alonso, Pedro
LeSouëf, Peter N.
Dobaño, Carlota, 1969-
Zhang, Guicheng (Brad)
author_role author
author2 Aguilar, Ruth
Guo, Jing
Manaca, Maria Nélia
Nhabomba, Augusto J.
Berthoud, Tamara
Khoo, Siew-Kim
Wiertsema, Selma
Barbosa, Arnoldo
Quintó, Llorenç
Laing, Ingrid
Mayor Aparicio, Alfredo Gabriel
Guinovart, Caterina
Alonso, Pedro
LeSouëf, Peter N.
Dobaño, Carlota, 1969-
Zhang, Guicheng (Brad)
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malària
Cordó umbilical
Infància
Malaria
Umbilical cord
Childhood
topic Malària
Cordó umbilical
Infància
Malaria
Umbilical cord
Childhood
description Using a well-designed longitudinal cohort, we aimed to identify cytokines that were protective against malaria and to explore how they were influenced by genetic and immunological factors. 349 Mozambican pregnant women and their newborn babies were recruited and followed up for malaria outcomes until 24 months of age. Six Th1 cytokines in cord blood were screened for correlation with malaria incidence, of which IL-12 was selected for further analyses. We genotyped IL-12 polymorphisms in children/mothers and evaluated the genotype-phenotype associations and genetic effects on IL-12 levels. Maternal IL-12 concentrations were also investigated in relation to Plasmodium infections and cord blood IL-12 levels. Our data showed that high background IL-12 levels were prospectively associated with a low incidence of clinical malaria, while IL-12 production after parasite stimulation had the opposite effect on malaria incidence. IL-12 genotypes (IL-12b rs2288831/rs17860508) and the haplotype CGTTAGAG distribution were related to malaria susceptibility and background IL-12 levels. Maternal genotypes also exhibited an evident impact on host genotype-phenotype associations. Finally, a positive correlation in background IL-12 levels between maternal and cord blood was identified. Thus, cord blood background IL-12 concentrations are important for protecting children from clinical malaria, likely mediated by both genotypes (children&mothers) and maternal immunity.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/134603
url https://hdl.handle.net/2445/134603
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1038/s41598-018-29179-y
Scientific Reports, 2018, vol. 8
http://dx.doi.org/10.1038/s41598-018-29179-y
dc.rights.none.fl_str_mv cc by (c) Song et al., 2018
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Song et al., 2018
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (ISGlobal)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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