Cumulative risk assessment of five phthalates in European children and adolescents
The European Human Biomonitoring Initiative (HBM4EU) assessed human biomonitoring data on phthalates in children and adolescents, that were sampled between 2014 and 2021, in a harmonised way. These so-called “HBM4EU Aligned Studies” revealed that almost all children and adolescents were exposed to m...
| Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | article |
| Publication Date: | 2022 |
| Country: | España |
| Institution: | Instituto de Salud Carlos III (ISCIII) |
| Repository: | Repisalud |
| Language: | English |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/15871 |
| Online Access: | http://hdl.handle.net/20.500.12105/15871 |
| Access Level: | Open access |
| Keyword: | Phthalic Acids Environmental Pollutants Child Adolescent Humans Risk Assessment Environmental Exposure Environmental Monitoring |
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Cumulative risk assessment of five phthalates in European children and adolescents |
| title |
Cumulative risk assessment of five phthalates in European children and adolescents |
| spellingShingle |
Cumulative risk assessment of five phthalates in European children and adolescents Lange, Rosa Phthalic Acids Environmental Pollutants Child Adolescent Humans Risk Assessment Environmental Exposure Environmental Monitoring |
| title_short |
Cumulative risk assessment of five phthalates in European children and adolescents |
| title_full |
Cumulative risk assessment of five phthalates in European children and adolescents |
| title_fullStr |
Cumulative risk assessment of five phthalates in European children and adolescents |
| title_full_unstemmed |
Cumulative risk assessment of five phthalates in European children and adolescents |
| title_sort |
Cumulative risk assessment of five phthalates in European children and adolescents |
| dc.creator.none.fl_str_mv |
Lange, Rosa Vogel, Nina Schmidt, Phillipp Gerofke, Antje Luijten, Mirjam Bil, Wieneke Santonen, Tiina Schoeters, Greet Gilles, Liese Sakhi, Amrit K Haug, Line S Jensen, Tina K Frederiksen, Hanne Koch, Holger M Szigeti, Tamás Szabados, Máté Tratnik, Janja Snoj Mazej, Darja Gabriel, Catherine Sarigiannis, Dimosthenis Dzhedzheia, Vazha Karakitsios, Spyros Rambaud, Loïc Riou, Margaux Koppen, Gudrun Covaci, Adrian Zvonař, Martin Piler, Pavel Klánová, Jana Fábelová, Lucia Richterová, Denisa Kosjek, Tina Runkel, Agneta Pedraza-Diaz, Susana Verheyen, Veerle Bastiaensen, Michiel Esteban-Lopez, Marta Castaño, Argelia Kolossa-Gehring, Marike |
| author |
Lange, Rosa |
| author_facet |
Lange, Rosa Vogel, Nina Schmidt, Phillipp Gerofke, Antje Luijten, Mirjam Bil, Wieneke Santonen, Tiina Schoeters, Greet Gilles, Liese Sakhi, Amrit K Haug, Line S Jensen, Tina K Frederiksen, Hanne Koch, Holger M Szigeti, Tamás Szabados, Máté Tratnik, Janja Snoj Mazej, Darja Gabriel, Catherine Sarigiannis, Dimosthenis Dzhedzheia, Vazha Karakitsios, Spyros Rambaud, Loïc Riou, Margaux Koppen, Gudrun Covaci, Adrian Zvonař, Martin Piler, Pavel Klánová, Jana Fábelová, Lucia Richterová, Denisa Kosjek, Tina Runkel, Agneta Pedraza-Diaz, Susana Verheyen, Veerle Bastiaensen, Michiel Esteban-Lopez, Marta Castaño, Argelia Kolossa-Gehring, Marike |
| author_role |
author |
| author2 |
Vogel, Nina Schmidt, Phillipp Gerofke, Antje Luijten, Mirjam Bil, Wieneke Santonen, Tiina Schoeters, Greet Gilles, Liese Sakhi, Amrit K Haug, Line S Jensen, Tina K Frederiksen, Hanne Koch, Holger M Szigeti, Tamás Szabados, Máté Tratnik, Janja Snoj Mazej, Darja Gabriel, Catherine Sarigiannis, Dimosthenis Dzhedzheia, Vazha Karakitsios, Spyros Rambaud, Loïc Riou, Margaux Koppen, Gudrun Covaci, Adrian Zvonař, Martin Piler, Pavel Klánová, Jana Fábelová, Lucia Richterová, Denisa Kosjek, Tina Runkel, Agneta Pedraza-Diaz, Susana Verheyen, Veerle Bastiaensen, Michiel Esteban-Lopez, Marta Castaño, Argelia Kolossa-Gehring, Marike |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Unión Europea. Comisión Europea. H2020 Federal Ministry for the Environment, Nature Conservation, Building and Nuclear Safety (Alemania) The Research Council of Norway Ministerio de Agricultura, Pesca y Alimentación (España) Instituto de Salud Carlos III Santé Publique France Ministère de la Santé (Francia) Novo Nordisk Foundation Norwegian Institute of Public Health Jožef Stefan Institute National Public Health Center (Hungría) Ministry of Health (Eslovaquia) Slovak Research and Development Agency Government of Flanders Odense University Hospital (Dinamarca) Region of Southern Denmark University of Southern Denmark (Dinamarca) Centre on Endocrine Disruptors (Dinamarca) Danish Research Council MEYS |
| dc.subject.none.fl_str_mv |
Phthalic Acids Environmental Pollutants Child Adolescent Humans Risk Assessment Environmental Exposure Environmental Monitoring |
| topic |
Phthalic Acids Environmental Pollutants Child Adolescent Humans Risk Assessment Environmental Exposure Environmental Monitoring |
| description |
The European Human Biomonitoring Initiative (HBM4EU) assessed human biomonitoring data on phthalates in children and adolescents, that were sampled between 2014 and 2021, in a harmonised way. These so-called “HBM4EU Aligned Studies” revealed that almost all children and adolescents were exposed to multiple phthalates concurrently. Some phthalates have been shown to act in a dose-additive manner, thus, a mixture risk assessment is warranted. In our study, we determine the risk from combined exposure to five anti-androgenic phthalates, namely DEHP, DiBP, DnBP, BBzP and DiNP by making use of the hazard index (HI) approach. Toxicologically-based human biomonitoring guidance values (HBM-GVs) derived within the framework of HBM4EU served as basis. Our results show that exposures of 17% of children and adolescents from twelve European countries resulted in hazard indices (HI) > 1 with an HI of 1.77 at the 95th percentile (geometric mean, GM = 0.44). Main drivers for the mixture risk are DnBP and DiBP. Generalized Linear Model (GLM) analysis including four major exposure determinants (age, sex, European region, sampling year) simultaneously reveal differences for the European regions and between sampling years. Children and adolescents living in the Eastern region of Europe have on average, higher HIs (GM=0.58) than in the Southern region (GM = 0.36) and Western region (GM = 0.42). Moreover, participants from which urine samples were taken in the earlier years (2014–2016) seem to have higher average HI levels than participants from studies with later sampling periods. Strikingly, the majority (63%) of participants with HIs > 1 would have gone unnoticed in single substance risk assessments as individual phthalates levels were below corresponding HBM-GVs. Thus, our results underline the importance of mixture risk assessment approaches to adequately address risks from concurrent chemical exposure. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022-09-01 2022 2022-09-01 2023 2023-04-21 |
| dc.type.none.fl_str_mv |
research article http://purl.org/coar/resource_type/c_2df8fbb1 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/20.500.12105/15871 |
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http://hdl.handle.net/20.500.12105/15871 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
European Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 733032 European Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 857560 EC ENV GR |
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open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf application/pdf |
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Elsevier |
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Elsevier |
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reponame:Repisalud instname:Instituto de Salud Carlos III (ISCIII) |
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Instituto de Salud Carlos III (ISCIII) |
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Repisalud |
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1869404058170687488 |
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Cumulative risk assessment of five phthalates in European children and adolescentsLange, RosaVogel, NinaSchmidt, PhillippGerofke, AntjeLuijten, MirjamBil, WienekeSantonen, TiinaSchoeters, GreetGilles, LieseSakhi, Amrit KHaug, Line SJensen, Tina KFrederiksen, HanneKoch, Holger MSzigeti, TamásSzabados, MátéTratnik, Janja SnojMazej, DarjaGabriel, CatherineSarigiannis, DimosthenisDzhedzheia, VazhaKarakitsios, SpyrosRambaud, LoïcRiou, MargauxKoppen, GudrunCovaci, AdrianZvonař, MartinPiler, PavelKlánová, JanaFábelová, LuciaRichterová, DenisaKosjek, TinaRunkel, AgnetaPedraza-Diaz, SusanaVerheyen, VeerleBastiaensen, MichielEsteban-Lopez, MartaCastaño, ArgeliaKolossa-Gehring, MarikePhthalic AcidsEnvironmental PollutantsChildAdolescentHumansRisk AssessmentEnvironmental ExposureEnvironmental MonitoringThe European Human Biomonitoring Initiative (HBM4EU) assessed human biomonitoring data on phthalates in children and adolescents, that were sampled between 2014 and 2021, in a harmonised way. These so-called “HBM4EU Aligned Studies” revealed that almost all children and adolescents were exposed to multiple phthalates concurrently. Some phthalates have been shown to act in a dose-additive manner, thus, a mixture risk assessment is warranted. In our study, we determine the risk from combined exposure to five anti-androgenic phthalates, namely DEHP, DiBP, DnBP, BBzP and DiNP by making use of the hazard index (HI) approach. Toxicologically-based human biomonitoring guidance values (HBM-GVs) derived within the framework of HBM4EU served as basis. Our results show that exposures of 17% of children and adolescents from twelve European countries resulted in hazard indices (HI) > 1 with an HI of 1.77 at the 95th percentile (geometric mean, GM = 0.44). Main drivers for the mixture risk are DnBP and DiBP. Generalized Linear Model (GLM) analysis including four major exposure determinants (age, sex, European region, sampling year) simultaneously reveal differences for the European regions and between sampling years. Children and adolescents living in the Eastern region of Europe have on average, higher HIs (GM=0.58) than in the Southern region (GM = 0.36) and Western region (GM = 0.42). Moreover, participants from which urine samples were taken in the earlier years (2014–2016) seem to have higher average HI levels than participants from studies with later sampling periods. Strikingly, the majority (63%) of participants with HIs > 1 would have gone unnoticed in single substance risk assessments as individual phthalates levels were below corresponding HBM-GVs. Thus, our results underline the importance of mixture risk assessment approaches to adequately address risks from concurrent chemical exposure.ElsevierUnión Europea. Comisión Europea. H2020Federal Ministry for the Environment, Nature Conservation, Building and Nuclear Safety (Alemania)The Research Council of NorwayMinisterio de Agricultura, Pesca y Alimentación (España)Instituto de Salud Carlos IIISanté Publique FranceMinistère de la Santé (Francia)Novo Nordisk FoundationNorwegian Institute of Public HealthJožef Stefan InstituteNational Public Health Center (Hungría)Ministry of Health (Eslovaquia)Slovak Research and Development AgencyGovernment of FlandersOdense University Hospital (Dinamarca)Region of Southern DenmarkUniversity of Southern Denmark (Dinamarca)Centre on Endocrine Disruptors (Dinamarca)Danish Research CouncilMEYS20232023-04-2120222022-09-0120222022-09-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/20.500.12105/15871reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengEuropean Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 733032European Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 857560EC ENV GRopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/158712026-06-12T12:43:37Z |
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