Impact of Cerebral Amyloid Angiopathy in Two Transgenic Mouse Models of Cerebral β-Amyloidosis: A Neuropathological Study
Microhemorragias cerebrales; Beta-amiloidosis cerebral; Resonancia magnética preclínica
| Autores: | , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:11351/8093 |
| Acesso em linha: | https://hdl.handle.net/11351/8093 http://hdl.handle.net/11351/8093 |
| Access Level: | acceso abierto |
| Palavra-chave: | Ratolins transgènics Amiloïdosi Malalties cerebrovasculars ORGANISMS::Eukaryota::Animals::Animal Population Groups::Animals, Genetically Modified::Mice, Transgenic DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Intracranial Arterial Diseases::Cerebral Arterial Diseases::Cerebral Amyloid Angiopathy CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Peptides::Amyloid beta-Peptides ORGANISMOS::Eukaryota::animales::grupos de población animal::animales modificados genéticamente::ratones transgénicos ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::enfermedades arteriales intracraneales::enfermedades arteriales cerebrales::angiopatía amiloide cerebral COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::péptidos beta amiloides |
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| dc.title.none.fl_str_mv |
Impact of Cerebral Amyloid Angiopathy in Two Transgenic Mouse Models of Cerebral β-Amyloidosis: A Neuropathological Study |
| title |
Impact of Cerebral Amyloid Angiopathy in Two Transgenic Mouse Models of Cerebral β-Amyloidosis: A Neuropathological Study |
| spellingShingle |
Impact of Cerebral Amyloid Angiopathy in Two Transgenic Mouse Models of Cerebral β-Amyloidosis: A Neuropathological Study Marazuela Fuentes, Paula Ratolins transgènics Amiloïdosi Malalties cerebrovasculars ORGANISMS::Eukaryota::Animals::Animal Population Groups::Animals, Genetically Modified::Mice, Transgenic DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Intracranial Arterial Diseases::Cerebral Arterial Diseases::Cerebral Amyloid Angiopathy CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Peptides::Amyloid beta-Peptides ORGANISMOS::Eukaryota::animales::grupos de población animal::animales modificados genéticamente::ratones transgénicos ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::enfermedades arteriales intracraneales::enfermedades arteriales cerebrales::angiopatía amiloide cerebral COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::péptidos beta amiloides |
| title_short |
Impact of Cerebral Amyloid Angiopathy in Two Transgenic Mouse Models of Cerebral β-Amyloidosis: A Neuropathological Study |
| title_full |
Impact of Cerebral Amyloid Angiopathy in Two Transgenic Mouse Models of Cerebral β-Amyloidosis: A Neuropathological Study |
| title_fullStr |
Impact of Cerebral Amyloid Angiopathy in Two Transgenic Mouse Models of Cerebral β-Amyloidosis: A Neuropathological Study |
| title_full_unstemmed |
Impact of Cerebral Amyloid Angiopathy in Two Transgenic Mouse Models of Cerebral β-Amyloidosis: A Neuropathological Study |
| title_sort |
Impact of Cerebral Amyloid Angiopathy in Two Transgenic Mouse Models of Cerebral β-Amyloidosis: A Neuropathological Study |
| dc.creator.none.fl_str_mv |
Marazuela Fuentes, Paula Paez Montserrat, Berta Bonaterra Pastra, Anna Solé Piñol, Montserrat Hernandez Guillamon, Maria Mar |
| author |
Marazuela Fuentes, Paula |
| author_facet |
Marazuela Fuentes, Paula Paez Montserrat, Berta Bonaterra Pastra, Anna Solé Piñol, Montserrat Hernandez Guillamon, Maria Mar |
| author_role |
author |
| author2 |
Paez Montserrat, Berta Bonaterra Pastra, Anna Solé Piñol, Montserrat Hernandez Guillamon, Maria Mar |
| author2_role |
author author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut Laboratori de Recerca Neurovascular, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Ratolins transgènics Amiloïdosi Malalties cerebrovasculars ORGANISMS::Eukaryota::Animals::Animal Population Groups::Animals, Genetically Modified::Mice, Transgenic DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Intracranial Arterial Diseases::Cerebral Arterial Diseases::Cerebral Amyloid Angiopathy CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Peptides::Amyloid beta-Peptides ORGANISMOS::Eukaryota::animales::grupos de población animal::animales modificados genéticamente::ratones transgénicos ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::enfermedades arteriales intracraneales::enfermedades arteriales cerebrales::angiopatía amiloide cerebral COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::péptidos beta amiloides |
| topic |
Ratolins transgènics Amiloïdosi Malalties cerebrovasculars ORGANISMS::Eukaryota::Animals::Animal Population Groups::Animals, Genetically Modified::Mice, Transgenic DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Intracranial Arterial Diseases::Cerebral Arterial Diseases::Cerebral Amyloid Angiopathy CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Peptides::Amyloid beta-Peptides ORGANISMOS::Eukaryota::animales::grupos de población animal::animales modificados genéticamente::ratones transgénicos ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::enfermedades arteriales intracraneales::enfermedades arteriales cerebrales::angiopatía amiloide cerebral COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::péptidos beta amiloides |
| description |
Microhemorragias cerebrales; Beta-amiloidosis cerebral; Resonancia magnética preclínica |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022 2022 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/11351/8093 http://hdl.handle.net/11351/8093 |
| url |
https://hdl.handle.net/11351/8093 http://hdl.handle.net/11351/8093 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
International Journal of Molecular Sciences;23(9) https://doi.org/10.3390/ijms23094972 info:eu-repo/grantAgreement/ES/PE2017-2020/PI20%2F00465 info:eu-repo/grantAgreement/ES/PE2017-2020/RD21%2F0006%2F0007 |
| dc.rights.none.fl_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
MDPI |
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MDPI |
| dc.source.none.fl_str_mv |
Scientia reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str |
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| reponame_str |
Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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|
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|
| _version_ |
1869404050207801344 |
| spelling |
Impact of Cerebral Amyloid Angiopathy in Two Transgenic Mouse Models of Cerebral β-Amyloidosis: A Neuropathological StudyMarazuela Fuentes, PaulaPaez Montserrat, BertaBonaterra Pastra, AnnaSolé Piñol, MontserratHernandez Guillamon, Maria MarRatolins transgènicsAmiloïdosiMalalties cerebrovascularsORGANISMS::Eukaryota::Animals::Animal Population Groups::Animals, Genetically Modified::Mice, TransgenicDISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Intracranial Arterial Diseases::Cerebral Arterial Diseases::Cerebral Amyloid AngiopathyCHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Peptides::Amyloid beta-PeptidesORGANISMOS::Eukaryota::animales::grupos de población animal::animales modificados genéticamente::ratones transgénicosENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::enfermedades arteriales intracraneales::enfermedades arteriales cerebrales::angiopatía amiloide cerebralCOMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::péptidos beta amiloidesMicrohemorragias cerebrales; Beta-amiloidosis cerebral; Resonancia magnética preclínicaCerebral microbleeds; Cerebral beta-amyloidosis; Preclinical MRIMicrohemorràgies cerebrals; Beta-amiloidosi cerebral; Ressonància magnètica preclínicaThe pathological accumulation of parenchymal and vascular amyloid-beta (Aβ) are the main hallmarks of Alzheimer’s disease (AD) and Cerebral Amyloid Angiopathy (CAA), respectively. Emerging evidence raises an important contribution of vascular dysfunction in AD pathology that could partially explain the failure of anti-Aβ therapies in this field. Transgenic mice models of cerebral β-amyloidosis are essential to a better understanding of the mechanisms underlying amyloid accumulation in the cerebrovasculature and its interactions with neuritic plaque deposition. Here, our main objective was to evaluate the progression of both parenchymal and vascular deposition in APP23 and 5xFAD transgenic mice in relation to age and sex. We first showed a significant age-dependent accumulation of extracellular Aβ deposits in both transgenic models, with a greater increase in APP23 females. We confirmed that CAA pathology was more prominent in the APP23 mice, demonstrating a higher progression of Aβ-positive vessels with age, but not linked to sex, and detecting a pronounced burden of cerebral microbleeds (cMBs) by magnetic resonance imaging (MRI). In contrast, 5xFAD mice did not present CAA, as shown by the negligible Aβ presence in cerebral vessels and the occurrence of occasional cMBs comparable to WT mice. In conclusion, the APP23 mouse model is an interesting tool to study the overlap between vascular and parenchymal Aβ deposition and to evaluate future disease-modifying therapy before its translation to the clinic.This work was funded by the Instituto de Salud Carlos III (ISCIII), (PI20/00465) and co-financed by the European Regional Development Fund (FEDER). The Neurovascular Research Laboratory is part of the RICORS-ICTUS-Enfermedades Vasculares Cerebrales network, ISCIII, Spain (RD21/0006/0007).MDPIInstitut Català de la SalutLaboratori de Recerca Neurovascular, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, SpainVall d'Hebron Barcelona Hospital Campus202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/8093http://hdl.handle.net/11351/8093Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésInternational Journal of Molecular Sciences;23(9)https://doi.org/10.3390/ijms23094972info:eu-repo/grantAgreement/ES/PE2017-2020/PI20%2F00465info:eu-repo/grantAgreement/ES/PE2017-2020/RD21%2F0006%2F0007Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/80932026-05-29T05:05:01Z |
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15,812455 |