Dysautonomia and small fiber neuropathy in post-COVID condition and Chronic Fatigue Syndrome
Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and post-COVID condition can present similarities such as fatigue, brain fog, autonomic and neuropathic symptoms. Methods The study included 87 patients with post-COVID condition, 50 patients with ME/CFS, and 50 healthy controls...
| Autores: | , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universidad del País Vasco |
| Repositorio: | Addi. Archivo Digital para la Docencia y la Investigación |
| OAI Identifier: | oai:addi.ehu.eus:10810/67469 |
| Acceso en línea: | http://hdl.handle.net/10810/67469 |
| Access Level: | acceso abierto |
| Palabra clave: | cognition dysautonomia myalgic encephalomyelitis/chronic fatigue syndrome post‑COVID condition small fiber neuropathy |
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Dysautonomia and small fiber neuropathy in post-COVID condition and Chronic Fatigue Syndrome |
| title |
Dysautonomia and small fiber neuropathy in post-COVID condition and Chronic Fatigue Syndrome |
| spellingShingle |
Dysautonomia and small fiber neuropathy in post-COVID condition and Chronic Fatigue Syndrome Azcue González, Naiara cognition dysautonomia myalgic encephalomyelitis/chronic fatigue syndrome post‑COVID condition small fiber neuropathy |
| title_short |
Dysautonomia and small fiber neuropathy in post-COVID condition and Chronic Fatigue Syndrome |
| title_full |
Dysautonomia and small fiber neuropathy in post-COVID condition and Chronic Fatigue Syndrome |
| title_fullStr |
Dysautonomia and small fiber neuropathy in post-COVID condition and Chronic Fatigue Syndrome |
| title_full_unstemmed |
Dysautonomia and small fiber neuropathy in post-COVID condition and Chronic Fatigue Syndrome |
| title_sort |
Dysautonomia and small fiber neuropathy in post-COVID condition and Chronic Fatigue Syndrome |
| dc.creator.none.fl_str_mv |
Azcue González, Naiara Del Pino Sáez, Rocío Acera Gil, María Ángeles Fernández Valle, Tamara Ayo Mentxakatorre, Naia Pérez Concha, Tomás Murueta-Goyena Larrañaga, Ane Lafuente Sánchez, José Vicente Prada, Alvaro López de Munain Arregui, Adolfo José Ruiz Irastorza, Guillermo Martín Iglesias, Daniel Ribacoba, Laureano Gabilondo Cuellar, Iñigo Gómez Esteban, Juan Carlos Tijero Merino, Beatriz |
| author |
Azcue González, Naiara |
| author_facet |
Azcue González, Naiara Del Pino Sáez, Rocío Acera Gil, María Ángeles Fernández Valle, Tamara Ayo Mentxakatorre, Naia Pérez Concha, Tomás Murueta-Goyena Larrañaga, Ane Lafuente Sánchez, José Vicente Prada, Alvaro López de Munain Arregui, Adolfo José Ruiz Irastorza, Guillermo Martín Iglesias, Daniel Ribacoba, Laureano Gabilondo Cuellar, Iñigo Gómez Esteban, Juan Carlos Tijero Merino, Beatriz |
| author_role |
author |
| author2 |
Del Pino Sáez, Rocío Acera Gil, María Ángeles Fernández Valle, Tamara Ayo Mentxakatorre, Naia Pérez Concha, Tomás Murueta-Goyena Larrañaga, Ane Lafuente Sánchez, José Vicente Prada, Alvaro López de Munain Arregui, Adolfo José Ruiz Irastorza, Guillermo Martín Iglesias, Daniel Ribacoba, Laureano Gabilondo Cuellar, Iñigo Gómez Esteban, Juan Carlos Tijero Merino, Beatriz |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
cognition dysautonomia myalgic encephalomyelitis/chronic fatigue syndrome post‑COVID condition small fiber neuropathy |
| topic |
cognition dysautonomia myalgic encephalomyelitis/chronic fatigue syndrome post‑COVID condition small fiber neuropathy |
| description |
Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and post-COVID condition can present similarities such as fatigue, brain fog, autonomic and neuropathic symptoms. Methods The study included 87 patients with post-COVID condition, 50 patients with ME/CFS, and 50 healthy controls (HC). The hemodynamic autonomic function was evaluated using the deep breathing technique, Valsalva maneuver, and Tilt test. The presence of autonomic and sensory small fiber neuropathy (SFN) was assessed with the Sudoscan and with heat and cold evoked potentials, respectively. Finally, a complete neuropsychological evaluation was performed. The objective of this study was to analyze and compare the autonomic and neuropathic symptoms in post-COVID condition with ME/CFS, and HC, as well as, analyze the relationship of these symptoms with cognition and fatigue. Results Statistically significant differences were found between groups in heart rate using the Kruskal–Wallis test (H), with ME/CFS group presenting the highest (H = 18.3; p ≤ .001). The Postural Orthostatic Tachycardia Syndrome (POTS), and pathological values in palms on the Sudoscan were found in 31% and 34% of ME/CFS, and 13.8% and 19.5% of post-COVID patients, respectively. Concerning evoked potentials, statistically significant differences were found in response latency to heat stimuli between groups (H = 23.6; p ≤ .01). Latency was highest in ME/CFS, and lowest in HC. Regarding cognition, lower parasympathetic activation was associated with worse cognitive performance. Conclusions Both syndromes were characterized by inappropriate tachycardia at rest, with a high percentage of patients with POTS. The prolonged latencies for heat stimuli suggested damage to unmyelinated fibers. The higher proportion of patients with pathological results for upper extremities on the Sudoscan suggested a non-length-dependent SFN. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2024 2024 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10810/67469 |
| url |
http://hdl.handle.net/10810/67469 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-023-04678-3 |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/3.0/es/ Atribución 3.0 España |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
http://creativecommons.org/licenses/by/3.0/es/ Atribución 3.0 España |
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application/pdf |
| dc.publisher.none.fl_str_mv |
BMC |
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BMC |
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reponame:Addi. Archivo Digital para la Docencia y la Investigación instname:Universidad del País Vasco |
| instname_str |
Universidad del País Vasco |
| reponame_str |
Addi. Archivo Digital para la Docencia y la Investigación |
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Addi. Archivo Digital para la Docencia y la Investigación |
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1869404049824022528 |
| spelling |
Dysautonomia and small fiber neuropathy in post-COVID condition and Chronic Fatigue SyndromeAzcue González, NaiaraDel Pino Sáez, RocíoAcera Gil, María ÁngelesFernández Valle, TamaraAyo Mentxakatorre, NaiaPérez Concha, TomásMurueta-Goyena Larrañaga, AneLafuente Sánchez, José VicentePrada, AlvaroLópez de Munain Arregui, Adolfo JoséRuiz Irastorza, GuillermoMartín Iglesias, DanielRibacoba, LaureanoGabilondo Cuellar, IñigoGómez Esteban, Juan CarlosTijero Merino, Beatrizcognitiondysautonomiamyalgic encephalomyelitis/chronic fatigue syndromepost‑COVID conditionsmall fiber neuropathyBackground Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and post-COVID condition can present similarities such as fatigue, brain fog, autonomic and neuropathic symptoms. Methods The study included 87 patients with post-COVID condition, 50 patients with ME/CFS, and 50 healthy controls (HC). The hemodynamic autonomic function was evaluated using the deep breathing technique, Valsalva maneuver, and Tilt test. The presence of autonomic and sensory small fiber neuropathy (SFN) was assessed with the Sudoscan and with heat and cold evoked potentials, respectively. Finally, a complete neuropsychological evaluation was performed. The objective of this study was to analyze and compare the autonomic and neuropathic symptoms in post-COVID condition with ME/CFS, and HC, as well as, analyze the relationship of these symptoms with cognition and fatigue. Results Statistically significant differences were found between groups in heart rate using the Kruskal–Wallis test (H), with ME/CFS group presenting the highest (H = 18.3; p ≤ .001). The Postural Orthostatic Tachycardia Syndrome (POTS), and pathological values in palms on the Sudoscan were found in 31% and 34% of ME/CFS, and 13.8% and 19.5% of post-COVID patients, respectively. Concerning evoked potentials, statistically significant differences were found in response latency to heat stimuli between groups (H = 23.6; p ≤ .01). Latency was highest in ME/CFS, and lowest in HC. Regarding cognition, lower parasympathetic activation was associated with worse cognitive performance. Conclusions Both syndromes were characterized by inappropriate tachycardia at rest, with a high percentage of patients with POTS. The prolonged latencies for heat stimuli suggested damage to unmyelinated fibers. The higher proportion of patients with pathological results for upper extremities on the Sudoscan suggested a non-length-dependent SFN.This study has been funded by Instituto de Salud Carlos III (ISCIII) through the project PI20/01076 and co‑funded by the European Union, EITB maratoia (BIOS21/COV/006) and grants for health research projects from the Basque Government (2021111006). Azcue, N. received a pre‑doctoral research grant from the basque government (PRE_2022_2_0111).BMC202420242023info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/67469reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://translational-medicine.biomedcentral.com/articles/10.1186/s12967-023-04678-3info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.Atribución 3.0 Españaoai:addi.ehu.eus:10810/674692026-06-18T09:23:17Z |
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15,300724 |