Adeno-associated viral vectors as versatile tools for neurological disorders: focus on delivery routes and therapeutic perspectives
It is without doubt that the gene therapy field is currently in the spotlight for the development of new therapeutics targeting unmet medical needs. Thus, considering the gene therapy scenario, neurological diseases in general and neurodegenerative disorders in particular are emerging as the most ap...
| Authors: | , , , , , , , , , , |
|---|---|
| Format: | article |
| Publication Date: | 2022 |
| Country: | España |
| Institution: | Asociación Española de Audiología |
| Repository: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Language: | English |
| OAI Identifier: | oai:dadun.unav.edu:10171/118490 |
| Online Access: | https://hdl.handle.net/10171/118490 |
| Access Level: | Open access |
| Keyword: | AAV Gene therapy Disease-modifying therapeutics Neuroprotection Precision medicine |
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Adeno-associated viral vectors as versatile tools for neurological disorders: focus on delivery routes and therapeutic perspectivesFajardo-Serrano, A. (Ana)|||/items/d93bf181-23cd-4267-98ec-609cd7a5a9feRico, A.J. (Alberto J.)|||/items/7a177958-067e-4900-943e-0271d63a5021Roda, E. (Elvira)|||/items/7ea91585-d2d9-4d11-aabf-4daab728ca1cHonrubia, A. (Adriana)|||/items/99298a39-e5c4-4985-a5db-f0eaa5863aafArrieta, S. (Sandra)|||/items/d8b5e9fa-4b6e-4bd5-a760-deaa9f000f3aAriznabarreta, G. (Goiaz)|||/items/1503f072-d975-41fd-8b31-76bbaf4d3da1Chocarro, J. (Julia)|||/items/1c162220-814c-4baf-9e72-4fa870e90680Lorenzo-Ramos, E. (Elena)|||/items/6c5a2c66-21e4-43c2-8dc8-f5bda58cb539Pejenaute-Martínez-de-Lizarrondo, Á. (Álvaro)|||/items/f10e17ed-8b4e-4d5c-8985-3f73a691f9d0Vazquez, A. (Alfonso)|||/items/7d5cb87e-5c97-4865-aea8-a4694ef0139fLanciego-Pérez, J.L. (José Luis)|||/items/d2d4dbfe-4daf-4103-89ec-2ebf41b65cd1AAVGene therapyDisease-modifying therapeuticsNeuroprotectionPrecision medicineIt is without doubt that the gene therapy field is currently in the spotlight for the development of new therapeutics targeting unmet medical needs. Thus, considering the gene therapy scenario, neurological diseases in general and neurodegenerative disorders in particular are emerging as the most appealing choices for new therapeutic arrivals intended to slow down, stop, or even revert the natural progressive course that characterizes most of these devastating neurodegenerative processes. Since an extensive coverage of all available literature is not feasible in practical terms, here emphasis was made in providing some advice to beginners in the field with a narrow focus on elucidating the best delivery route available for fulfilling any given AAV-based therapeutic approach. Furthermore, it is worth nothing that the number of ongoing clinical trials is increasing at a breathtaking speed. Accordingly, a landscape view of preclinical and clinical initiatives is also provided here in an attempt to best illustrate what is ongoing in this quickly expanding field.MDPIDadun. Depósito Académico Digital Universidad de Navarra20222022-01-0120222022-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/118490reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Asociación Española de AudiologíaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/1184902026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Adeno-associated viral vectors as versatile tools for neurological disorders: focus on delivery routes and therapeutic perspectives |
| title |
Adeno-associated viral vectors as versatile tools for neurological disorders: focus on delivery routes and therapeutic perspectives |
| spellingShingle |
Adeno-associated viral vectors as versatile tools for neurological disorders: focus on delivery routes and therapeutic perspectives Fajardo-Serrano, A. (Ana)|||/items/d93bf181-23cd-4267-98ec-609cd7a5a9fe AAV Gene therapy Disease-modifying therapeutics Neuroprotection Precision medicine |
| title_short |
Adeno-associated viral vectors as versatile tools for neurological disorders: focus on delivery routes and therapeutic perspectives |
| title_full |
Adeno-associated viral vectors as versatile tools for neurological disorders: focus on delivery routes and therapeutic perspectives |
| title_fullStr |
Adeno-associated viral vectors as versatile tools for neurological disorders: focus on delivery routes and therapeutic perspectives |
| title_full_unstemmed |
Adeno-associated viral vectors as versatile tools for neurological disorders: focus on delivery routes and therapeutic perspectives |
| title_sort |
Adeno-associated viral vectors as versatile tools for neurological disorders: focus on delivery routes and therapeutic perspectives |
| dc.creator.none.fl_str_mv |
Fajardo-Serrano, A. (Ana)|||/items/d93bf181-23cd-4267-98ec-609cd7a5a9fe Rico, A.J. (Alberto J.)|||/items/7a177958-067e-4900-943e-0271d63a5021 Roda, E. (Elvira)|||/items/7ea91585-d2d9-4d11-aabf-4daab728ca1c Honrubia, A. (Adriana)|||/items/99298a39-e5c4-4985-a5db-f0eaa5863aaf Arrieta, S. (Sandra)|||/items/d8b5e9fa-4b6e-4bd5-a760-deaa9f000f3a Ariznabarreta, G. (Goiaz)|||/items/1503f072-d975-41fd-8b31-76bbaf4d3da1 Chocarro, J. (Julia)|||/items/1c162220-814c-4baf-9e72-4fa870e90680 Lorenzo-Ramos, E. (Elena)|||/items/6c5a2c66-21e4-43c2-8dc8-f5bda58cb539 Pejenaute-Martínez-de-Lizarrondo, Á. (Álvaro)|||/items/f10e17ed-8b4e-4d5c-8985-3f73a691f9d0 Vazquez, A. (Alfonso)|||/items/7d5cb87e-5c97-4865-aea8-a4694ef0139f Lanciego-Pérez, J.L. (José Luis)|||/items/d2d4dbfe-4daf-4103-89ec-2ebf41b65cd1 |
| author |
Fajardo-Serrano, A. (Ana)|||/items/d93bf181-23cd-4267-98ec-609cd7a5a9fe |
| author_facet |
Fajardo-Serrano, A. (Ana)|||/items/d93bf181-23cd-4267-98ec-609cd7a5a9fe Rico, A.J. (Alberto J.)|||/items/7a177958-067e-4900-943e-0271d63a5021 Roda, E. (Elvira)|||/items/7ea91585-d2d9-4d11-aabf-4daab728ca1c Honrubia, A. (Adriana)|||/items/99298a39-e5c4-4985-a5db-f0eaa5863aaf Arrieta, S. (Sandra)|||/items/d8b5e9fa-4b6e-4bd5-a760-deaa9f000f3a Ariznabarreta, G. (Goiaz)|||/items/1503f072-d975-41fd-8b31-76bbaf4d3da1 Chocarro, J. (Julia)|||/items/1c162220-814c-4baf-9e72-4fa870e90680 Lorenzo-Ramos, E. (Elena)|||/items/6c5a2c66-21e4-43c2-8dc8-f5bda58cb539 Pejenaute-Martínez-de-Lizarrondo, Á. (Álvaro)|||/items/f10e17ed-8b4e-4d5c-8985-3f73a691f9d0 Vazquez, A. (Alfonso)|||/items/7d5cb87e-5c97-4865-aea8-a4694ef0139f Lanciego-Pérez, J.L. (José Luis)|||/items/d2d4dbfe-4daf-4103-89ec-2ebf41b65cd1 |
| author_role |
author |
| author2 |
Rico, A.J. (Alberto J.)|||/items/7a177958-067e-4900-943e-0271d63a5021 Roda, E. (Elvira)|||/items/7ea91585-d2d9-4d11-aabf-4daab728ca1c Honrubia, A. (Adriana)|||/items/99298a39-e5c4-4985-a5db-f0eaa5863aaf Arrieta, S. (Sandra)|||/items/d8b5e9fa-4b6e-4bd5-a760-deaa9f000f3a Ariznabarreta, G. (Goiaz)|||/items/1503f072-d975-41fd-8b31-76bbaf4d3da1 Chocarro, J. (Julia)|||/items/1c162220-814c-4baf-9e72-4fa870e90680 Lorenzo-Ramos, E. (Elena)|||/items/6c5a2c66-21e4-43c2-8dc8-f5bda58cb539 Pejenaute-Martínez-de-Lizarrondo, Á. (Álvaro)|||/items/f10e17ed-8b4e-4d5c-8985-3f73a691f9d0 Vazquez, A. (Alfonso)|||/items/7d5cb87e-5c97-4865-aea8-a4694ef0139f Lanciego-Pérez, J.L. (José Luis)|||/items/d2d4dbfe-4daf-4103-89ec-2ebf41b65cd1 |
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author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
AAV Gene therapy Disease-modifying therapeutics Neuroprotection Precision medicine |
| topic |
AAV Gene therapy Disease-modifying therapeutics Neuroprotection Precision medicine |
| description |
It is without doubt that the gene therapy field is currently in the spotlight for the development of new therapeutics targeting unmet medical needs. Thus, considering the gene therapy scenario, neurological diseases in general and neurodegenerative disorders in particular are emerging as the most appealing choices for new therapeutic arrivals intended to slow down, stop, or even revert the natural progressive course that characterizes most of these devastating neurodegenerative processes. Since an extensive coverage of all available literature is not feasible in practical terms, here emphasis was made in providing some advice to beginners in the field with a narrow focus on elucidating the best delivery route available for fulfilling any given AAV-based therapeutic approach. Furthermore, it is worth nothing that the number of ongoing clinical trials is increasing at a breathtaking speed. Accordingly, a landscape view of preclinical and clinical initiatives is also provided here in an attempt to best illustrate what is ongoing in this quickly expanding field. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022-01-01 2022 2022-01-01 |
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journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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https://hdl.handle.net/10171/118490 |
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https://hdl.handle.net/10171/118490 |
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Inglés eng |
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Inglés |
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eng |
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open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Asociación Española de Audiología |
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Asociación Española de Audiología |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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