High triglycerides and low HDL-c lipid profile in rheumatoid arthritis: a potential link among inflammation, oxidative status and dysfunctional HDL

Background The interactions between inflammation and lipid profile in rheumatoid arthritis (RA) are poorly understood. The lipid profile study in RA has been biased toward lipoprotein levels, whereas those of triglycerides (TGs) and lipoprotein functionality have been underestimated. Objectives Sinc...

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Autores: Rodríguez Carrio, Javier, Alperi López, Mercedes, López, Patricia, López Mejías, Raquel, Alonso Castro, Sara, Abal, Francisco, Ballina García, Francisco J., González-Gay Mantecón, Miguel Ángel, Suárez, Ana
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/12092
Acceso en línea:http://hdl.handle.net/10902/12092
Access Level:acceso abierto
Palabra clave:High density lipoproteins
Triglycerides
Triglyceride-rich lipoproteins
Paraoxonase
28 inflammation
Oxidative status
Rheumatoid arthritis
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spelling High triglycerides and low HDL-c lipid profile in rheumatoid arthritis: a potential link among inflammation, oxidative status and dysfunctional HDLRodríguez Carrio, JavierAlperi López, MercedesLópez, PatriciaLópez Mejías, RaquelAlonso Castro, SaraAbal, FranciscoBallina García, Francisco J.González-Gay Mantecón, Miguel ÁngelSuárez, AnaHigh density lipoproteinsTriglyceridesTriglyceride-rich lipoproteinsParaoxonase28 inflammationOxidative statusRheumatoid arthritisBackground The interactions between inflammation and lipid profile in rheumatoid arthritis (RA) are poorly understood. The lipid profile study in RA has been biased toward lipoprotein levels, whereas those of triglycerides (TGs) and lipoprotein functionality have been underestimated. Objectives Since recent findings suggest a role for TG and TG-rich lipoproteins (TRL) on inflammation, we aimed to evaluate a combined lipid profile characterized by high TG and low high-density lipoprotein cholesterol levels (TGhighHDLlow) in RA. Methods Lipid profiles were analyzed in 113 RA patients, 113 healthy controls, and 27 dyslipemic subjects. Levels of inflammatory mediators, paraoxonase-1 (PON1) activity, and total antioxidant capacity were quantified in serum. PON1-rs662 status was evaluated by real-time polymerase chain reaction. Results The TGhighHDLlow profile was detected in 29/113 RA patients. Although no differences in prevalence compared with healthy controls or dyslipemic subjects were observed, this profile was associated with increased tumor necrosis factor ? (P = .004), monocyte chemotactic protein (P = .004), interferon-gamma?inducible protein-10 (P = .018), and leptin (P < .001) serum levels in RA, where decreased PON1 activity and total antioxidant capacity were found. TGhighHDLlow prevalence was lower among anti-TNF??treated patients (P = .004). When RA patients were stratified by PON1-rs662 status, these associations remained in the low-activity genotype (QQ). Finally, a poor clinical response on TNF? blockade was related to an increasing prevalence of the TGhighHDLlow profile over treatment (P = .021) and higher TRL levels at baseline (P = .042). Conclusions The TGhighHDLlow profile is associated with systemic inflammation, decreased PON1 activity, and poor clinical outcome on TNF? blockade in RA, suggesting a role of TRL and HDL dysfunction as the missing link between inflammation and lipid profile.This work was supported by European Union FEDER funds, “Fondo de Investigación Sanitaria (FIS, PI12/00523 and PI16/00113; ISCIII, Spain) and SER/FER funds (Sociedad Española de Reumatología, FER043/2016). J.R.-C. is supported by a postdoctoral contract from the “Juan de la Cierva” program (FJCI-2015-23849; MINECO, Spain).ElsevierUniversidad de Cantabria20172017-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttp://hdl.handle.net/10902/12092Journal of Clinical Lipidology (2017), Volume 11, Issue 4, July-August 2017, Pages 1043-1054.e2reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/120922026-06-02T12:39:31Z
dc.title.none.fl_str_mv High triglycerides and low HDL-c lipid profile in rheumatoid arthritis: a potential link among inflammation, oxidative status and dysfunctional HDL
title High triglycerides and low HDL-c lipid profile in rheumatoid arthritis: a potential link among inflammation, oxidative status and dysfunctional HDL
spellingShingle High triglycerides and low HDL-c lipid profile in rheumatoid arthritis: a potential link among inflammation, oxidative status and dysfunctional HDL
Rodríguez Carrio, Javier
High density lipoproteins
Triglycerides
Triglyceride-rich lipoproteins
Paraoxonase
28 inflammation
Oxidative status
Rheumatoid arthritis
title_short High triglycerides and low HDL-c lipid profile in rheumatoid arthritis: a potential link among inflammation, oxidative status and dysfunctional HDL
title_full High triglycerides and low HDL-c lipid profile in rheumatoid arthritis: a potential link among inflammation, oxidative status and dysfunctional HDL
title_fullStr High triglycerides and low HDL-c lipid profile in rheumatoid arthritis: a potential link among inflammation, oxidative status and dysfunctional HDL
title_full_unstemmed High triglycerides and low HDL-c lipid profile in rheumatoid arthritis: a potential link among inflammation, oxidative status and dysfunctional HDL
title_sort High triglycerides and low HDL-c lipid profile in rheumatoid arthritis: a potential link among inflammation, oxidative status and dysfunctional HDL
dc.creator.none.fl_str_mv Rodríguez Carrio, Javier
Alperi López, Mercedes
López, Patricia
López Mejías, Raquel
Alonso Castro, Sara
Abal, Francisco
Ballina García, Francisco J.
González-Gay Mantecón, Miguel Ángel
Suárez, Ana
author Rodríguez Carrio, Javier
author_facet Rodríguez Carrio, Javier
Alperi López, Mercedes
López, Patricia
López Mejías, Raquel
Alonso Castro, Sara
Abal, Francisco
Ballina García, Francisco J.
González-Gay Mantecón, Miguel Ángel
Suárez, Ana
author_role author
author2 Alperi López, Mercedes
López, Patricia
López Mejías, Raquel
Alonso Castro, Sara
Abal, Francisco
Ballina García, Francisco J.
González-Gay Mantecón, Miguel Ángel
Suárez, Ana
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv High density lipoproteins
Triglycerides
Triglyceride-rich lipoproteins
Paraoxonase
28 inflammation
Oxidative status
Rheumatoid arthritis
topic High density lipoproteins
Triglycerides
Triglyceride-rich lipoproteins
Paraoxonase
28 inflammation
Oxidative status
Rheumatoid arthritis
description Background The interactions between inflammation and lipid profile in rheumatoid arthritis (RA) are poorly understood. The lipid profile study in RA has been biased toward lipoprotein levels, whereas those of triglycerides (TGs) and lipoprotein functionality have been underestimated. Objectives Since recent findings suggest a role for TG and TG-rich lipoproteins (TRL) on inflammation, we aimed to evaluate a combined lipid profile characterized by high TG and low high-density lipoprotein cholesterol levels (TGhighHDLlow) in RA. Methods Lipid profiles were analyzed in 113 RA patients, 113 healthy controls, and 27 dyslipemic subjects. Levels of inflammatory mediators, paraoxonase-1 (PON1) activity, and total antioxidant capacity were quantified in serum. PON1-rs662 status was evaluated by real-time polymerase chain reaction. Results The TGhighHDLlow profile was detected in 29/113 RA patients. Although no differences in prevalence compared with healthy controls or dyslipemic subjects were observed, this profile was associated with increased tumor necrosis factor ? (P = .004), monocyte chemotactic protein (P = .004), interferon-gamma?inducible protein-10 (P = .018), and leptin (P < .001) serum levels in RA, where decreased PON1 activity and total antioxidant capacity were found. TGhighHDLlow prevalence was lower among anti-TNF??treated patients (P = .004). When RA patients were stratified by PON1-rs662 status, these associations remained in the low-activity genotype (QQ). Finally, a poor clinical response on TNF? blockade was related to an increasing prevalence of the TGhighHDLlow profile over treatment (P = .021) and higher TRL levels at baseline (P = .042). Conclusions The TGhighHDLlow profile is associated with systemic inflammation, decreased PON1 activity, and poor clinical outcome on TNF? blockade in RA, suggesting a role of TRL and HDL dysfunction as the missing link between inflammation and lipid profile.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10902/12092
url http://hdl.handle.net/10902/12092
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Journal of Clinical Lipidology (2017), Volume 11, Issue 4, July-August 2017, Pages 1043-1054.e2
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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